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watch: documentary transcript

 (WOMAN)
WELCOME TO THE FUTURE. . .

00 min. 06 sec.
PBS DIGITAL.

00 min. 09 sec.

VO Announcer: The Forgetting: A Portrait of Alzheimer’s has been funded by MetLife Foundation.

MetLife CEO Rob Henrikson: Welcome to The Forgetting, a portrait of families struggling with Alzheimer’s disease and the scientists searching for a solution. For over 25 years MetLife Foundation has been involved in the fight against Alzheimer's. As part of our ongoing commitment, we're proud to support this important program.

VO Announcer: And by contributions to your PBS station from viewers like you. Thank you. 


00 min. 29 sec.
[ORCHESTRA & PIANO PLAY SOFTLY]

00 min. 31 sec.
¦
¦

00 min. 36 sec.
(MAUREEN)  I REMEMBER HER

00 min. 37 sec.
GETTING UP IN THE MIDDLE OF THE NIGHT TO GO TO WORK.

00 min. 40 sec.
I'D SAY MOM, WHAT ARE YOU DOING?  IT'S 1:00 IN THE MORNING.               

00 min. 44 sec.
SHE WOULD LOOK AT ME REALLY CONFUSED, YOU KNOW?

00 min. 46 sec.
AND THEN SHE WOULD PRETEND THAT SHE KNEW WHAT SHE WAS DOING,                

00 min. 50 sec.
BUT YOU COULD TELL THAT SHE DIDN'T.

00 min. 52 sec.
HER HANDS ARE SO WARM.

00 min. 54 sec.
YOU'RE HANDS ARE SO WARM, MOM.

00 min. 57 sec.
SHE CONSTANTLY WAS HIDING THINGS LIKE YOU'D FIND STRANGE THINGS                

01 min. 00 sec.
LIKE KEYS IN THE REFRIGERATOR.

01 min. 02 sec.
(HELEN)  AND EVENTUALLY WE ALL SAID

01 min. 05 sec.
WE THINK THAT MOM'S DEVELOPING ALZHEIMER'S.

01 min. 09 sec.

01 min. 11 sec.
(BUTCH)  WE KNEW SHE WAS GOING TO LOSE HER MEMORY,

01 min. 14 sec.
BUT I DON'T THINK WE WERE PREPARED FOR WHAT TRANSPIRED.                

01 min. 18 sec.
I LOVE YOU. I LOVE YOU FRAN.

01 min. 21 sec.
I LOVE YOU FRAN.

01 min. 24 sec.
DADDY, I DON'T WANNA. . .

01 min. 27 sec.
(JULIE)  PEOPLE ASK ME SO, HOW IS YOUR SISTER,

01 min. 30 sec.
AND I THINK WHAT AM I GOING TO TELL YOU.

01 min. 34 sec.
SHE'S LOSING HER MIND.

01 min. 35 sec.
[WHISPERS]  YOU'RE SAFE.

01 min. 40 sec.
ALZHEIMER'S DISEASE ROBS YOU OF WHO YOU ARE.

01 min. 43 sec.
I DON'T THINK THERE'S ANY GREATER FEAR FOR A PERSON               

01 min. 47 sec.
THAN TO THINK I’VE LIVED MY WHOLE LIFE

01 min. 51 sec.
ACCUMULATING ALL THESE MEMORIES, ALL OF THESE VALUE SYSTEMS,

01 min. 55 sec.
ALL OF THIS PLACE AND MY FAMILY AND A SOCIETY.

01 min. 59 sec.
AND HERE'S A DISEASE THAT'S JUST GOING TO COME IN

02 min. 03 sec.
AND EVERY SINGLE DAY JUST RIP OUT THE CONNECTIONS,

02 min. 07 sec.
JUST TEAR OUT THE SEAMS

02 min. 09 sec.
THAT ACTUALLY DEFINE WHO I AM AS A PERSON.

02 min. 13 sec.

02 min. 15 sec.
ALZHEIMER'S HAS JUST MUSHROOMED IN JUST THE LAST 15 YEARS                

02 min. 19 sec.
FROM THIS RELATIVELY RARE DISORDER      

02 min. 21 sec.
TO THIS EXTREMELY COMMON PHENOMENON      

02 min. 23 sec.
BECAUSE SO MANY OF US ARE LIVING TO THE AGES

02 min. 27 sec.
WHERE THE RISKS ARE SO SIGNIFICANT.

02 min. 29 sec.
(HARRY)  IT FEELS LIKE YOU'RE ON A CONSTANT TREADMILL.

02 min. 32 sec.
(GLADYS)  GET OFF OF ME! GET OFF.

02 min. 34 sec.
(HARRY)  GLADYS IS OPERATING

02 min. 36 sec.
AT THE LEVEL OF A 4-YEAR-OLD AND WANTING HER WAY.

02 min. 39 sec.
(GLADYS) SHUT UP.

02 min. 41 sec.
I DON'T LIKE HIM.

02 min. 42 sec.
AND I DON'T LIKE HER EITHER!

02 min. 44 sec.
AND HE CAN'T UNDERSTAND THAT IT'S NOT HER, IT'S THE DISEASE,                

02 min. 48 sec.
BUT THERE'S NO ESCAPE.

02 min. 50 sec.
YOU KNOW, THERE'S NO WAY OUT.

02 min. 53 sec.
     ME?

02 min. 54 sec.
(DAVID SCHENK)  THIS IS THE DISEASE THAT CAN AFFECT ANYONE.

02 min. 58 sec.
THERE IS NOT A SINGLE PERSON ON EARTH

03 min. 00 sec.
WHO IS IMMUNE TO ALZHEIMER'S DISEASE.

03 min. 02 sec.
DO YOU KNOW WHAT THE DATE IS TODAY?

03 min. 04 sec.
THE DATE?

03 min. 06 sec.
NO, I DON'T THINK SO.

03 min. 10 sec.
(DAVID SCHENK)  WE'RE IN THE MIDDLE OF AN EPIDEMIC.

03 min. 13 sec.
WE ABSOLUTELY HAVE TO STOP THIS DISEASE.

03 min. 16 sec.
THERE'S JUST NO CHOICE.

03 min. 18 sec.
AS A NATION, AS AN ECONOMY,

03 min. 20 sec.
AS A CIVILIZATION, WE HAVE TO END IT NOW.

03 min. 24 sec.
¦
¦

03 min. 45 sec.

03 min. 56 sec.
[HARP PLAYS SOFTLY]

03 min. 58 sec.
¦
¦

04 min. 00 sec.
SHE'D GET UP AT LIKE 2 A.M.

04 min. 02 sec.
AND GET READY FOR WORK, AND THEN IT'D BE LIKE,

04 min. 05 sec.
SHE'D HAVE TO WALK THROUGH MY ROOM TO GO TO THE BATHROOM.      

04 min. 08 sec.
I'D BE LIKE, MOM,

04 min. 10 sec.
IT'S ONLY 2:00 IN THE MORNING OR THINGS LIKE THAT.

04 min. 12 sec.
(THOMAS MCKENNA)  YEAH, SHE WOULD START A LITTLE JOB,

04 min. 15 sec.
AND SHE'D GET EVERYTHING ALL SET UP.

04 min. 17 sec.
THEN SHE WOULD LEAVE AND 5 MINUTES SHE'D COME BACK      

04 min. 21 sec.
SHE FORGOT WHERE SHE WAS, WHAT SHE HAD TO DO TO FINISH.

04 min. 25 sec.
(MAUREEN)  SHE WOULD JUST DO THE SAME TASKS OVER AND OVER AGAIN.       

04 min. 28 sec.
YOU KNOW LIKE PUT THE TOAST IN THE OVEN,

04 min. 31 sec.
THE TOAST WOULD COME OUT, IN THE TOASTER,

04 min. 33 sec.
AND THEN SHE'D PUT IT BACK IN THE TOASTER.

04 min. 35 sec.
THEN SHE LOST A LOT OF WEIGHT.

04 min. 38 sec.
WE THOUGHT SHE WAS JUST DOING TOO MUCH

04 min. 40 sec.
'CAUSE SHE WAS WORKING THAT EARLY AND MAYBE

04 min. 43 sec.
IT WAS THE SCHEDULE,  AND SHE WAS JUST TIRED.

04 min. 46 sec.
(FEMALE NARRATOR)  ALL OF THIS STRANGE BEHAVIOR

04 min. 49 sec.
WAS COMPLETELY OUT OF CHARACTER FOR ISABEL MCKENNA

04 min. 52 sec.
WHO ALL HER LIFE HAD BEEN FULL OF ENERGY AND FUN.

04 min. 57 sec.
[SWING BAND PLAYS]

04 min. 59 sec.
¦
¦

05 min. 03 sec.
(THOMAS)  SHE WAS GREAT.

05 min. 05 sec.
SHE WAS ALWAYS SMILIN'.

05 min. 06 sec.
THE KIDS USED TO LOVE HER, SHE'D TAKE THEM EVERYWHERE.

05 min. 11 sec.

05 min. 12 sec.
(WOMAN)  THEY WERE A GREAT COUPLE, ALWAYS LAUGHING.

05 min. 15 sec.
I MEAN THEY DID HAVE THEIR HARD TIMES,

05 min. 18 sec.
BUT YOU COULD TELL HOW MUCH THEY LOVED EACH OTHER.

05 min. 22 sec.
HE HAD JUST RETIRED,

05 min. 24 sec.
AND THEY WERE GONNA DO ALL THESE GREAT THINGS TOGETHER,                

05 min. 29 sec.
AND IT NEVER HAPPENED FOR THEM BECAUSE THIS DISEASE CAME.                

05 min. 34 sec.
(NARRATOR)  IN 1990, ISABEL MCKENNA

05 min. 38 sec.
WAS DIAGNOSED WITH ALZHEIMER'S DISEASE.

05 min. 42 sec.
WE DIDN'T KNOW MUCH ABOUT IT. BUT WE'D HEARD OF IT, YOU KNOW?              

05 min. 46 sec.
WE NEVER THOUGHT IT WOULD HAPPEN TO HER, BUT THAT'S WHAT IT WAS.                

05 min. 51 sec.
¦
¦

06 min. 00 sec.
[SINGING SOFTLY]

06 min. 02 sec.
HI, ISABEL.

06 min. 04 sec.
HOW YA DOIN', SWEETHEART?

06 min. 07 sec.
WHAT'S BOTHERING YOU, HUH?

06 min. 10 sec.
DID YOU HAVE A GOOD NIGHT LAST NIGHT?

06 min. 16 sec.
YOU TIRED?

06 min. 18 sec.

06 min. 21 sec.
[SMACK!]

06 min. 23 sec.
NICE DAY, HUM?

06 min. 25 sec.
(DR. JOHN GROWDON)  IT'S A TRAGIC ILLNESS

06 min. 28 sec.
WHERE THE ESSENCE OF THE PERSON

06 min. 33 sec.
SLOWLY EBBS AWAY.

06 min. 35 sec.
MEDICALLY, SHE'S TOWARD THE END OF IT.

06 min. 37 sec.
STATISTICALLY, SHE'S TOWARD THE END OF IT.  

06 min. 40 sec.
IN TERMS OF DURATION OF ILLNESS IS AT THE EDGE.

06 min. 43 sec.

06 min. 48 sec.
HOW ABOUT SOME MUSIC.

06 min. 51 sec.

06 min. 52 sec.
[PIANO PLAYS "HAIL, HAIL, THE GANG'S ALL HERE"

06 min. 55 sec.
(PEOPLE SING)  ¦ HAIL, HAIL, THE GANG'S ALL HERE ¦

06 min. 58 sec.
¦ WHAT THE HECK DO WE CARE. ¦

07 min. 00 sec.
¦ WHAT THE HECK DO WE CARE. ¦

07 min. 02 sec.
THERE HE GOES.  WHAT DO YOU THINK?

07 min. 05 sec.
[TALKS WITH EFFORT]

07 min. 07 sec.
[LAUGHS]

07 min. 09 sec.
ARE YOU MAD AT HIM TODAY, HUH?

07 min. 12 sec.

07 min. 13 sec.
WHAT? HUH?

07 min. 15 sec.
THINK YOU'RE HAVIN' A PARTY?

07 min. 17 sec.
THIS HAS BEEN A LONG, DRAWN OUT DAY

07 min. 20 sec.
THAT HAS, YOU KNOW,

07 min. 22 sec.
WORN ON ALL OF US FOR THE PAST 13 YEARS HERE.

07 min. 26 sec.
I MEAN, I REALLY SEE IT AS TORTURE.  

07 min. 31 sec.
I SEE IT AS SOMEBODY WHO'S TRAPPED

07 min. 35 sec.
AND FEEL HELPLESS ABOUT WHAT WE CAN DO ABOUT THAT.

07 min. 41 sec.
THIS IS A DEPRESSINGLY TYPICAL.

07 min. 43 sec.
IT'S ALMOST A STEREOTYPE PATTERN WHICH YOU COULD SUPERIMPOSE                

07 min. 49 sec.
HUNDREDS OF PATIENTS ON THIS SAME COURSE OF ILLNESS.  

07 min. 54 sec.

07 min. 57 sec.
(THOMAS)  IT JUST KEEPS GETTIN' WORSE,

07 min. 59 sec.
IT JUST KEEPS GOING ON AND ON.

08 min. 03 sec.
HUH?

08 min. 04 sec.
OH I MISS HER.

08 min. 07 sec.
I MISS HER.

08 min. 10 sec.

08 min. 15 sec.
(NARRATOR)  ALZHEIMER'S DISEASE IS A SLOW AND SILENT KILLER.  

08 min. 20 sec.
IT DRAWS THE CURTAINS OVER A PATIENT'S LIFE

08 min. 24 sec.
AND PULLS FAMILIES INTO ITS DEVASTATING GRIP.

08 min. 28 sec.
FOR OVER A CENTURY, SCIENTISTS HAVE BEEN STRUGGLING               

08 min. 32 sec.
TO UNRAVEL THIS PROFOUND MYSTERY.

08 min. 35 sec.
TANTALIZING NEW CLUES ARE EMERGING, AND BREAKTHROUGHS              

08 min. 39 sec.
ARE ESPECIALLY CRITICAL NOW

08 min. 41 sec.
IN THE FACE OF A LOOMING PUBLIC HEALTH DISASTER.

08 min. 45 sec.
FIFTEEN YEARS AGO,

08 min. 47 sec.
THERE WERE APPROXIMATELY 500,000 AMERICANS WITH ALZHEIMER'S.                

08 min. 52 sec.
TODAY THERE ARE 5 MILLION,

08 min. 55 sec.
10 TIMES AS MANY.

08 min. 57 sec.
IT USED TO BE JUST THIS INDIVIDUAL TRAGEDY.  

09 min. 00 sec.
NOW IT'S AN INDIVIDUAL TRAGEDY,

09 min. 02 sec.
THAT IS HAPPENING SO MANY TIMES

09 min. 05 sec.
IT'S BECOMING A SOCIAL TRAGEDY AND AN ECONOMIC TRAGEDY.              

09 min. 08 sec.

09 min. 10 sec.
(NARRATOR)  EVERY YEAR PAST AGE 65,

09 min. 13 sec.
THE PERCENTAGE OF PEOPLE WITH ALZHEIMER'S INCREASES.     

09 min. 17 sec.
BY THE TIME YOU REACH 75, YOU HAVE A 10% CHANCE.

09 min. 22 sec.
IF YOU LIVE PAST 85, THE NUMBERS ARE MUCH WORSE.

09 min. 26 sec.
ANYWHERE FROM 25% OF THE PEOPLE OVER 85

09 min. 29 sec.
TO EVEN AS HIGH IN ONE STUDY AS 47% OF PEOPLE OVER 85

09 min. 34 sec.
HAVE SOME LEVEL OF DEMENTIA.

09 min. 36 sec.
THAT'S AN INCREDIBLE NUMBER OF PEOPLE WITH DISEASE.

09 min. 38 sec.
WE NOW HAVE 4 TO 5 MILLION AMERICANS WHO HAVE THE DISEASE.                

09 min. 42 sec.
THEY'RE ESTIMATING THAT THE TOTAL ECONOMIC COST OF THAT--              

09 min. 44 sec.
PEOPLE LOSING THEIR JOBS, PEOPLE HAVING TO

09 min. 46 sec.
GIVE UP THEIR JOBS TO TAKE CARE OF THEIR LOVED ONES,

09 min. 49 sec.
ALL THE MEDICAL COSTS ASSOCIATED WITH THE DISEASE--              

09 min. 51 sec.
OVER $100 BILLION ALREADY ANNUALLY.                

09 min. 55 sec.

09 min. 57 sec.
BUT THAT IS GONNA BE DWARFED

10 min. 00 sec.
WHEN THE BABY BOOMERS START TO TURN 65.

10 min. 04 sec.
WHEN THE BABY BOOMERS START TO GET THIS DISEASE,  

10 min. 08 sec.
THOSE NUMBERS ARE GONNA EXPLODE.

10 min. 11 sec.
¦
¦

10 min. 13 sec.
(RUDOLPH TANZI)  IF YOU LOOK AT THE COST OF ALZHEIMER'S NOW, AND

10 min. 17 sec.
YOU LOOK AT HOW MANY PATIENTS

10 min. 19 sec.
WE'RE GOING TO HAVE IN 2030

10 min. 21 sec.
BECAUSE OF THE BABY BOOMER PHENOMENON,              

10 min. 24 sec.
THEN IT CAN BE PREDICTED

10 min. 25 sec.
THAT OUR ENTIRE FEDERAL BUDGET WILL BE CONSUMED              

10 min. 28 sec.
CARING FOR ALZHEIMER PATIENTS BY 2030 IF WE DON'T DO SOMETHING  

10 min. 31 sec.
ABOUT THIS DISEASE BETWEEN NOW AND THEN.  

10 min. 33 sec.

10 min. 38 sec.
(NARRATOR)  BUT A CENTURY AGO,

10 min. 40 sec.
THE DISEASE WAS SO RARE IT DIDN'T EVEN HAVE A NAME.       

10 min. 45 sec.
(DAVID SCHENK)  THE TERM ALZHEIMER COMES FROM ALOIS ALZHEIMER

10 min. 49 sec.
WHO WAS A GERMAN DOCTOR AT THE BEGINNING OF THE 20TH CENTURY,                

10 min. 54 sec.
BOTH A CLINICIAN AND A RESEARCHER ACTUALLY.  

10 min. 58 sec.
HE WAS THE ATTENDING PHYSICIAN AT A MENTAL HOSPITAL.                

11 min. 02 sec.
IN 1901, A 51-YEAR-OLD WOMAN WHO WE KNOW AS AUGUST D.

11 min. 08 sec.
WAS BROUGHT IN BY HER HUSBAND.

11 min. 11 sec.
SHE WAS VERY CONFUSED AND HAVING SOME HALLUCINATIONS

11 min. 15 sec.
AND SOME PRETTY SERIOUS PARANOIA AS WELL.              

11 min. 19 sec.
BY HAPPENSTANCE, DR. ALZHEIMER HAPPENED TO BE

11 min. 22 sec.
THE PERSON WHO MET HER FIRST.

11 min. 25 sec.
HE ASKED HER A SERIES OF QUESTIONS ABOUT HER NAME,

11 min. 28 sec.
AND SHE WAS NOT EVEN REALLY ABLE TO TELL HER FULL NAME              

11 min. 32 sec.
SO HER TOLD HER HER NAME,

11 min. 34 sec.
HE SPOKE HER NAME, "FRAU AUGUST D.,"

11 min. 36 sec.
AND SHE WROTE FRAU AND COULDN'T GET THE REST SO HE REPEATED IT.                

11 min. 43 sec.
"YOUR NAME IS AUGUST D.,"

11 min. 45 sec.
AND SHE WROTE AGU. . .AND AGAIN, SHE COULDN'T EVEN REMEMBER              

11 min. 49 sec.
HER FULL NAME HAVING JUST BEEN SPOKEN TO HER.

11 min. 53 sec.
AND SHE PUT DOWN THE PENCIL AND SAID, I’VE LOST MYSELF.

11 min. 59 sec.

12 min. 03 sec.
(RUDOLPH TANZI)  SHE WAS SLOWLY DECAYING.

12 min. 05 sec.
SHE LOST HER ABILITY TO REASON,

12 min. 07 sec.
AND THE CLASSIC SYMPTOMS OF WHAT WE NOW THINK OF

12 min. 11 sec.
AS ALZHEIMER'S WERE HAPPENING RAPIDLY

12 min. 13 sec.
IN THIS YOUNG, YOU KNOW, RELATIVELY YOUNG WOMAN.

12 min. 16 sec.
(NARRATOR)  ALZHEIMER CLOSELY OBSERVED AUGUST D. FOR 5 YEARS.  

12 min. 20 sec.
WHEN SHE DIED, HE WAS DETERMINED TO FIND

12 min. 25 sec.
THE CAUSE OF HER MYSTERIOUS ILLNESS.

12 min. 28 sec.
HE HAD A HUNCH THAT IT WAS SOMETHING MORE              

12 min. 32 sec.
THAN AN EMOTIONAL PROBLEM.

12 min. 34 sec.
ALZHEIMER AT THE TIME WAS DOING SOMETHING REALLY REVOLUTIONARY                

12 min. 38 sec.
BY LOOKING FOR EVIDENCE FOR SOMETHING PHYSICALLY

12 min. 42 sec.
GOING WRONG IN THE BRAIN TO EXPLAIN A MENTAL DISORDER.

12 min. 47 sec.
THIS JUST WASN'T THE CONVENTIONAL THINKING BACK THEN.                

12 min. 51 sec.
THE THOUGHT BACK THEN WAS THAT PSYCHIATRIC DISORDERS INVOLVED                

12 min. 55 sec.
DISTURBANCES IN ELECTRO-- THE ELECTRICITY OF THE BRAIN

12 min. 58 sec.
AND THE MAGNETISM OF THE BRAIN AND THE MYSTERIOUS FLUIDS              

13 min. 02 sec.
THAT ALLOW US TO HAVE CONSCIOUSNESS.

13 min. 05 sec.
(NARRATOR)  WITH A BRAND NEW STAINING            
TECHNIQUE USING SILVER,  

13 min. 09 sec.
ALZHEIMER MADE THESE SLIDES

13 min. 11 sec.
OF CELLS FROM INSIDE AUGUST D.'S BRAIN.

13 min. 15 sec.
LOOKING AT THEM UNDER THIS MICROSCOPE,

13 min. 18 sec.
HE DREW SKETCHES OF SOMETHING OMINOUS.

13 min. 21 sec.
(RUDOLPH TANZI)  SOMETHING STRUCK HIM IN THAT HE SAW

13 min. 26 sec.
WHAT HE CALLED "MILIARY BODIES,"

13 min. 29 sec.
AND THESE WERE THESE LARGE DEPOSITS

13 min. 31 sec.
OF SOMETHING STICKY IN THE BRAIN

13 min. 34 sec.
THAT FOR ALL INTENTS AND PURPOSES LOOKED LIKE STARCH.              

13 min. 39 sec.
AND INSIDE, THE NERVE CELLS WERE CHOKED

13 min. 42 sec.
WITH THESE TWISTED FIBRILS.

13 min. 44 sec.
(NARRATOR)  THESE STARCHY DEPOSITS AND TWISTED FIBRILS

13 min. 48 sec.
CONFIRMED ALZHEIMER'S HUNCH.

13 min. 50 sec.
FOR THE FIRST TIME IN HISTORY,

13 min. 54 sec.
THESE PLAQUES AND TANGLES WERE DEFINITIVE PROOF                

13 min. 58 sec.
OF A PHYSICAL CAUSE FOR WHAT SEEMED LIKE A MENTAL ILLNESS.              

14 min. 05 sec.
THIS STRANGE DISORDER THAT HAD KILLED AUGUST D.

14 min. 10 sec.
CAME TO BE CALLED ALZHEIMER'S DISEASE.

14 min. 13 sec.

14 min. 19 sec.
TODAY, ALZHEIMER'S DISEASE IS THE LEADING CAUSE                

14 min. 23 sec.
OF DEMENTIA AND MEMORY LOSS IN OLDER PEOPLE.  

14 min. 27 sec.

14 min. 34 sec.
IS HE READY?

14 min. 35 sec.
ARE YOU READY?

14 min. 36 sec.
WE'RE GONNA GO
SEE THE DOC.

14 min. 38 sec.
(NARRATOR)  GLADYS FUGET IS 74.

14 min. 40 sec.
SHE AND HER HUSBAND, HARRY,

14 min. 43 sec.
LIVE IN PITTSBURGH.

14 min. 44 sec.
THEY'VE BEEN MARRIED FOR 45 YEARS.  

14 min. 47 sec.
[BIG BAND PLAYS]

14 min. 49 sec.
(HARRY)  I MET HER IN BALTIMORE.

14 min. 52 sec.
I WAS IN THE SERVICE.

14 min. 54 sec.
AND I RENTED AN APARTMENT IN THIS APARTMENT BUILDING,  

14 min. 58 sec.
AND SHE HAPPENED TO BE ONE OF THE NEIGHBORS.

15 min. 02 sec.
SHE LIKED TO DANCE.

15 min. 04 sec.
WE'D DO THAT KIND OF STUFF.

15 min. 06 sec.
AND I DANCED THE FIRST DANCE WITH HER,

15 min. 09 sec.
AND AFTER THAT, SHE STAYED ON THE FLOOR, AND SHE DANCED.

15 min. 13 sec.
SO WE HAD A REAL BALL.  

15 min. 15 sec.
SHE WAS A. . .

15 min. 18 sec.
IN MY TERMINOLOGY,

15 min. 20 sec.
SHE WAS A GOOD-LOOKING CHICK, AND EASY-GOING.

15 min. 25 sec.
CAN YOU SLIDE BACK A LITTLE BIT HERE.  

15 min. 28 sec.
I WANNA SEE YOUR KNEES KINDA BE RIGHT BACK AGAINST THIS.              

15 min. 31 sec.
OK, THAT'S WHAT I WANT.

15 min. 33 sec.
DOES HE TAKE PRETTY GOOD CARE OF YOU, MISS FUGET?

15 min. 35 sec.
(NARRATOR)  DR. STEVEN DEKOSKY RUNS THE  ALZHEIMER'S RESEARCH CENTER  

15 min. 39 sec.
AT THE UNIVERSITY OF PITTSBURGH.

15 min. 41 sec.
THIS IS GOOD.  NOW, I’M GOING TO

15 min. 43 sec.
GIVE YOU 3 THINGS TO REMEMBER,

15 min. 45 sec.
AND I’M GONNA ASK YOU TO REMEMBER THEM.  

15 min. 47 sec.
IN ABOUT 5 MINUTES,

15 min. 49 sec.
I’M GOING ASK YOU TO TELL ME WHAT THEY WERE, OK?                

15 min. 51 sec.
A HOUSE, A LAKE, AND A SHOE.

15 min. 53 sec.
CAN YOU SAY THOSE FOR ME?

15 min. 55 sec.
A HOUSE, A LAKE, AND A SHOE.

15 min. 57 sec.
GOOD. I’M GOING TO ASK YOU TO TELL

16 min. 00 sec.
ME WHAT THEY WERE IN ABOUT 5 MINUTES.

16 min. 02 sec.
BUT IN THE MEANTIME,

16 min. 04 sec.
WE'RE GONNA MOVE ON TO A COUPLE OF OTHER THINGS.  

16 min. 06 sec.
OKAY, THAT'S ALRIGHT.

16 min. 07 sec.
CAN YOU SPELL THE WORD, WORLD FOR ME?

16 min. 09 sec.
W-O-R-L-D.

16 min. 11 sec.
GREAT. CAN YOU SPELL IT FOR ME BACKWARDS?

16 min. 14 sec.
NO, I DON'T THINK SO.

16 min. 16 sec.
OKAY, YOU GOT IT FORWARDS.  YOU WANT TO GIVE IT A TRY?

16 min. 20 sec.
WELL, LET'S SEE.

16 min. 22 sec.

16 min. 24 sec.
L-R-D?

16 min. 29 sec.
OKAY, OKAY, GOOD.

16 min. 30 sec.
I'D LIKE YOU TO CLOSE YOUR EYES FOR ME

16 min. 32 sec.
I'LL PUT SOME THINGS IN YOUR HAND, DON'T LOOK AT THEM.              

16 min. 35 sec.
I JUST WANT YOU TO FEEL THEM AND TELL ME WHAT THEY ARE.

16 min. 38 sec.
SO HERE'S SOMETHING.  YOU TELL ME WHAT THIS IS.

16 min. 40 sec.
DON'T LOOK AT IT, JUST TELL ME WHAT IT IS.

16 min. 42 sec.
I CAN TOUCH IT?

16 min. 43 sec.
YES MA'AM. YOU CAN DO ANYTHING YOU WANT EXCEPT LOOK AT IT.              

16 min. 46 sec.
OH, I LOOKED AT IT!

16 min. 48 sec.
YES, YOU DID.

16 min. 49 sec.
OKAY. NOW YOU CLOSE YOUR EYES AGAIN,

16 min. 51 sec.
AND I'LL PUT SOMETHING ELSE IN YOUR HAND.  

16 min. 54 sec.
THAT'S SOMETHING FLAT.

16 min. 55 sec.
SOMETHING FLAT.

16 min. 56 sec.
IS IT A KEY?

16 min. 57 sec.
NO, IT'S NOT A KEY.

16 min. 59 sec.
IS IT A COIN?

17 min. 00 sec.
UH-HUH, VERY GOOD.

17 min. 01 sec.
SHE'S ABLE TO IDENTIFY THINGS IN HER HAND,

17 min. 03 sec.
AND SHE GIVES ME THE NAME. SHE DOESN'T HESITATE.              

17 min. 05 sec.
SHE DID SAY THAT IS SOMETHING YOU OPEN A DOOR WITH.                

17 min. 07 sec.
MISS FUGET, A FEW MINUTES AGO I ASKED YOU TO REMEMBER 3 OBJECTS,                

17 min. 11 sec.
THEN I SAID I'LL ASK YOU IN A FEW MINUTES WHAT THEY WERE.     

17 min. 14 sec.
DO YOU REMEMBER THOSE 3 THINGS?

17 min. 16 sec.
NO, I DON'T.

17 min. 18 sec.
DO YOU REMEMBER ME ASKING YOU, TELLING YOU 3 THINGS?              

17 min. 21 sec.
I REMEMBER YOU TELLING ME SOMETHING,

17 min. 23 sec.
BUT I DON'T REMEMBER WHAT IT WAS.

17 min. 25 sec.
BUT YOU DON'T REMEMBER WHAT THEY ARE? >> NO.

17 min. 28 sec.
I WOULD SAY THAT SHE'S IN THE MIDDLE OF

17 min. 30 sec.
MODERATE ALZHEIMER'S DISEASE AT THIS POINT IN TIME.

17 min. 34 sec.
HER MEMORY, AND HER ABILITY

17 min. 36 sec.
TO KEEP INSTRUCTIONS IN MEMORY   VERY LONG IS IMPAIRED.

17 min. 39 sec.
SHE CAN SPELL THE WORD, WORLD, FORWARD WITH NO TROUBLE,                

17 min. 42 sec.
BUT SHE CANNOT TURN IT AROUND

17 min. 44 sec.
WHICH IS A MEMORY-REQUIRING TASK FOR THE SHORT TERM.              

17 min. 46 sec.
(HARRY)  SHE DOESN'T REMEMBER LATE IN THE AFTERNOON

17 min. 48 sec.
WHAT WE'VE HAD FOR BREAKFAST OR IF WE'VE HAD BREAKFAST.

17 min. 51 sec.
DID YOU EAT BREAKFAST THIS MORNING?  

17 min. 53 sec.
NOT MUCH.

17 min. 55 sec.
YES, YOU DID.

17 min. 56 sec.
WHAT'D I GIVE YOU FOR BREAKFAST? WHAT WAS IT?

17 min. 59 sec.
SOMETHING YOU HAD COOKED.

18 min. 00 sec.
YEAH?

18 min. 02 sec.
SHE PRETTY MUCH IS ALWAYS DENYING

18 min. 04 sec.
THAT THERE'S ANYTHING WRONG.

18 min. 06 sec.
(HARRY)  ABSOLUTELY.  AND THE DIFFICULTY IS

18 min. 10 sec.
THAT SHE'S BEEN THIS WAY ALL OF OUR RELATIONSHIP.

18 min. 15 sec.
THE DIFFERENCE NOW IS THAT SHE DOESN'T DENY THIS BECAUSE

18 min. 18 sec.
SHE IS DENYING IT LIKE SHE USED TO DENY OTHER THINGS.

18 min. 22 sec.
NOW SHE JUST--THE PART THE BRAIN THAT LETS YOU RECOGNIZE                

18 min. 25 sec.
THAT YOU HAVE A THINKING PROBLEM ISN'T WORKING.                

18 min. 27 sec.
THAT'S RIGHT.

18 min. 29 sec.
(NARRATOR)  IN THE EARLY YEARS OF ALZHEIMER'S,

18 min. 32 sec.
GLADYS IS NOT YET SERIOUSLY IMPAIRED.

18 min. 34 sec.
(GLADYS) WHERE WERE WE?
(HARRY) IN GERMANY.

18 min. 37 sec.
(NARRATOR)   BUT WITH EACH DAY THAT PASSES,

18 min. 40 sec.
THE INEVITABLE PROGRESSION OF THE DISEASE

18 min. 43 sec.
IS SLOWLY ERASING PRECIOUS AND IRREPLACEABLE MEMORIES.

18 min. 46 sec.
FRAN.

18 min. 47 sec.
THAT'S FRAN.

18 min. 49 sec.
YEAH, THAT'S FRAN.

18 min. 50 sec.
WHO'S THAT DOWN AT THE BOTTOM?

18 min. 52 sec.
THAT'S YOU AND CATHY. THAT'S YOU.

18 min. 55 sec.
(HARRY)  THE DISEASE IS ROBBING US

18 min. 58 sec.
OF WHAT LITTLE TIME THAT REMAINS,

19 min. 02 sec.
AND IT LOOKS BLEAK AND FRIGHTENING AHEAD.

19 min. 06 sec.
THE FUTURE IS NOT SOMEPLACE I’M MADLY DASHING TO GET TO.  

19 min. 10 sec.
BUT IT'S GONNA GET ME WHETHER OR NOT I’M READY FOR IT.

19 min. 15 sec.
I’VE JUST GOT TO TRY AND BE READY FOR IT WHEN IT GETS HERE.                

19 min. 18 sec.

19 min. 21 sec.
(NARRATOR)  THE SPECTER OF DEMENTIA IN OLD AGE

19 min. 24 sec.
HAS FASCINATED AND TERRIFIED HUMAN BEINGS

19 min. 27 sec.
FOR ALL OF RECORDED HISTORY.

19 min. 29 sec.
AS FAR BACK AS 2800 B.C.,

19 min. 33 sec.
AN ANCIENT EGYPTIAN MYTH TELLS THE STORY

19 min. 37 sec.
OF THE SON GOD, RA, ALL-KNOWING, ALL-POWERFUL,

19 min. 42 sec.
AND IMMORTAL, BUT IN A CRUEL TWIST,

19 min. 46 sec.
LOSING HIS MEMORY AND LIVING FOREVER IN A SENILE HAZE.              

19 min. 52 sec.
IT'S ONE OF THE MOST BASIC HUMAN FEARS,

19 min. 56 sec.
THE LOSS OF MEMORY,

19 min. 59 sec.
THE LOSS OF SELF.

20 min. 01 sec.
(RUDOLPH TANZI)  IT'S THE ULTIMATE ATTACK

20 min. 04 sec.
ON THE HEALTHY PERSON

20 min. 06 sec.
TO LOSE THE VERY ESSENCE OF WHO YOU ARE.

20 min. 10 sec.
I WILL NO LONGER KNOW WHO I AM.

20 min. 13 sec.
MY FAMILY, FRIENDS, AND LOVED ONES

20 min. 16 sec.
WILL NO LONGER KNOW ME AS MYSELF.

20 min. 19 sec.
(NARRATOR)  SHAKESPEARE UNMASKS THE DREAD OF DEMENTIA IN "KING LEER"

20 min. 24 sec.
WHEN THE AGING MONARCH CAN'T SEEM

20 min. 27 sec.
TO REMEMBER HIS DAUGHTER OR HIS CLOSE FRIENDS.

20 min. 31 sec.
I FEAR I’M NOT IN MY PERFECT MIND.  

20 min. 36 sec.
METHINKS I SHOULD KNOW YOU.

20 min. 40 sec.
I KNOW THIS MAN.

20 min. 46 sec.
YET I AM DOUBTFUL.

20 min. 51 sec.
FOR I AM MERELY LEARNED WHAT PLACE THIS IS

20 min. 57 sec.
AND ALL THE SKILL I HAVE REMEMBERS NOT THESE GARMENTS         

21 min. 02 sec.
NOR I KNOW NOT WHERE I DID LODGE LAST NIGHT.

21 min. 08 sec.

21 min. 11 sec.

21 min. 13 sec.
(DAVID SCHENK)  MEMORIES ARE WHO WE ARE. . .

21 min. 18 sec.
DO NOT LAUGH AT ME.

21 min. 20 sec.
AND THERE IS SOMETHING EXISTENTIALLY TERRIFYING                

21 min. 23 sec.
ABOUT HAVING YOUR MEMORIES RIPPED OUT OF YOUR HEAD,                

21 min. 27 sec.
WHICH IS BASICALLY HOW THIS DISEASE BEGINS.  

21 min. 31 sec.

21 min. 33 sec.
(NARRATOR)  THE HUMAN BRAIN IS A MIRACULOUS AND COMPLEX ORGAN

21 min. 39 sec.
THAT CONTROLS EVERY BREATH, THOUGHT, HEARTBEAT, AND EMOTION.              

21 min. 43 sec.
WE HAVE A HUNDRED BILLION NEURONS OR NERVE CELLS,                

21 min. 48 sec.
PROBABLY ABOUT A HUNDRED TRILLION SYNAPSES              

21 min. 51 sec.
OR CONNECTIONS TO YOUR NERVE CELLS.

21 min. 53 sec.
SO WHAT YOU HAVE IS

21 min. 56 sec.
THIS INCREDIBLY INTRICATE NEURAL NETWORK.

21 min. 58 sec.

22 min. 00 sec.
(NARRATOR)  THIS AMAZING NETWORK IS     
MAINTAINED     

22 min. 03 sec.
BY CAREFULLY ORCHESTRATED CHEMICAL AND ELECTRICAL SIGNALS              

22 min. 07 sec.
TRAVELING A MASSIVE SYSTEM OF NERVE CELL PATHWAYS.

22 min. 12 sec.
NEW THOUGHTS AND MEMORIES ARE THE RESULT

22 min. 17 sec.
OF INFORMATION TRAVELING BETWEEN SYNAPSES

22 min. 20 sec.
AS THEY FORM, DISSOLVE, AND FORM AGAIN.

22 min. 25 sec.
THE SYMPTOMS OF ALZHEIMER'S BEGIN

22 min. 28 sec.
WHEN THIS DELICATE SIGNALING SYSTEM IS DISRUPTED.              

22 min. 33 sec.
THE FIRST PATHWAY THAT'S ATTACKED

22 min. 35 sec.
LEADS TO A PART OF THE BRAIN CALLED THE HIPPOCAMPUS,              

22 min. 40 sec.
WHICH IS CRUCIAL TO MEMORY.

22 min. 43 sec.
STICKY PLAQUES FORM BETWEEN NERVE CELLS

22 min. 48 sec.
AND BLOCK COMMUNICATION.

22 min. 50 sec.
THEN LONG, STRINGY TANGLES CHOKE THE NERVE CELLS FROM THE INSIDE.                

22 min. 57 sec.
NEURONS CAN NO LONGER TALK TO ONE ANOTHER,

23 min. 02 sec.
AND SYNAPSES BEGIN TO DISAPPEAR.

23 min. 06 sec.
(RUDOLPH TANZI)  WHAT'S TRULY AMAZING ABOUT A DISEASE LIKE ALZHEIMER'S

23 min. 11 sec.
IS THAT THE SYSTEM IS BEING SO RAVAGED

23 min. 15 sec.
IN TERMS OF LOSS OF MAINLY SYNAPSES,

23 min. 18 sec.
AND MEMORIES CAN BE COMPLETELY LOST FOREVER.  

23 min. 21 sec.
BELIEVE IT OR NOT, THAT'S A VERY DIFFICULT THING TO DO IN THE BRAIN

23 min. 26 sec.
GIVEN JUST HOW MUCH BACKUP THERE IS IN THE NETWORK.

23 min. 30 sec.
(NARRATOR)  AS THE HIPPOCAMPUS IS SLOWLY DESTROYED,

23 min. 34 sec.
FEWER AND FEWER NEW THOUGHTS ARE ABLE TO FORM,

23 min. 39 sec.
AND THE FORGETTING BEGINS.

23 min. 41 sec.
VERY GRADUALLY, ALMOST IMPERCEPTIBLY AT FIRST,                

23 min. 45 sec.
NAMES AND WORDS ARE HARD TO RECALL.  

23 min. 50 sec.
FAMILIAR PLACES  MAY SEEM TOTALLY FOREIGN.  

23 min. 54 sec.
AS THE PLAQUES AND TANGLES CONTINUE TO SPREAD,                

23 min. 59 sec.
NEURONS START TO DIE, AND THE BRAIN BEGINS TO SHRINK.

24 min. 06 sec.
EVERYDAY TASKS AND FAMILIAR ACTIONS ARE SUDDENLY IMPOSSIBLE.                

24 min. 11 sec.
BY THE MIDDLE STAGES, SEVERAL YEARS INTO THE DISEASE,

24 min. 16 sec.
MILLIONS OF SYNAPSES HAVE DISSOLVED AWAY,

24 min. 20 sec.
AND AREAS OF THE BRAIN CONTROLLING EMOTION              

24 min. 24 sec.
ARE HIT HARD.

24 min. 26 sec.
PERSONALITY CHANGES,

24 min. 28 sec.
ANGER, PARANOIA, AND FEAR CAN ERUPT WITHOUT WARNING.  

24 min. 35 sec.
EVENTUALLY, ALMOST ALL OF THE BRAIN IS TAKEN OVER.

24 min. 41 sec.
LONG-TERM MEMORIES DISAPPEAR.

24 min. 44 sec.
LOVED ONES TURN INTO STRANGERS.

24 min. 50 sec.
SPEECH FADES INTO SILENCE.

24 min. 55 sec.
FINALLY, THE PARTS OF THE BRAIN

24 min. 59 sec.
WHICH CONTROL OUR MOST BASIC FUNCTIONS--SWALLOWING              

25 min. 03 sec.
AND EVEN BREATHING--SHUT DOWN.

25 min. 06 sec.
THE TIME BETWEEN DIAGNOSIS AND DEATH

25 min. 10 sec.
IS ANYWHERE FROM 8 TO 20 YEARS.

25 min. 14 sec.

25 min. 18 sec.
OKAY, NEXT CASE.

25 min. 20 sec.
(NARRATOR)  IN HOSPITALS AND CLINICS ACROSS THE COUNTRY,

25 min. 24 sec.
DOCTORS SEE HUNDREDS OF THOUSANDS              

25 min. 26 sec.
OF NEW PATIENTS EACH YEAR

25 min. 28 sec.
AS THE EPIDEMIC OF ALZHEIMER'S CONTINUES TO GROW.              

25 min. 31 sec.
IN HER INTERVIEW, SHE DOESN'T COME ACROSS AS TERRIBLY PARANOID              

25 min. 34 sec.
SO IT IS INTERESTING THAT SHE'S GOT THAT SYMPTOM AND THAT ATROPHY.

25 min. 36 sec.
(NARRATOR)  AT THE UNIVERSITY OF PITTSBURGH,             
MOST PATIENTS COME

25 min. 40 sec.
AFTER YEARS OF MINOR FORGETTING, WHEN FAMILY MEMBERS             

25 min. 43 sec.
FINALLY FACE THE FACT  THAT SOMETHING IS WRONG.

25 min. 46 sec.
(WOMAN)  SHE HAD FORGETFULNESS,

25 min. 48 sec.
OFTEN FORGETTING WHERE SHE PUT HER GLASSES OR HER KEYS,                

25 min. 50 sec.
AND THIS HAS INCREASED GRADUALLY.
. .              

25 min. 52 sec.
(DR. STEVEN DEKOSKY)  SOMETIMES IT'S ODD CHANGES IN BEHAVIOR.   

25 min. 56 sec.
SOMETIMES IT'S INTERMITTENT.

25 min. 58 sec.
HE COULDN'T QUITE STRAIGHTEN OUT THE CHECKBOOK.             

26 min. 00 sec.
THAT HAD NEVER BEEN A PROBLEM BEFORE.

26 min. 03 sec.
SHE COULDN'T QUITE RECALL EXACTLY HOW TO DO SOMETHING             

26 min. 06 sec.
IN THE KITCHEN.  THAT HAD NEVER HAPPENED BEFORE.

26 min. 09 sec.
BUT USUALLY BECAUSE THIS DISORDER STARTS SO SLOWLY                

26 min. 12 sec.
AND MOVES SO SLOWLY, ESPECIALLY IN THE BEGINNING,

26 min. 16 sec.
PEOPLE USUALLY ASSOCIATE THOSE CHANGES WITH A SENIOR MOMENT             

26 min. 21 sec.
OR SOME KIND OF CHANGE OF AGING, AND WE PASS A LOT OF IT OVER.             

26 min. 28 sec.
OK, I WOULD START HERE WITH THE 2.

26 min. 32 sec.
(NARRATOR)  EVERYONE WITH A MEMORY PROBLEM

26 min. 34 sec.
WANTS TO ANSWER THE CRITICAL QUESTION--

26 min. 37 sec.
IS IT NORMAL AGING OR IS IT ALZHEIMER'S?

26 min. 40 sec.
(WOMAN)  LET'S START AGAIN.

26 min. 42 sec.
PUT THEM FLAT, AND TURN ONE PALM UP. THAT'S IT.

26 min. 44 sec.
REGIS SCULLY HAS COME TO

26 min. 46 sec.
DEKOSKY'S CLINIC FOR A SERIES OF TESTS TO FIND OUT.

26 min. 50 sec.
YOU'RE GETTING THERE.

26 min. 52 sec.
KEEP THE PATTERN GOING ALL THE WAY ACROSS THE PAGE.   

26 min. 56 sec.
YOU CAN STOP. THAT'S GOOD.

26 min. 58 sec.
(JUDITH SAXTON)  ALZHEIMER'S DISEASE AFFECTS THE BRAIN IN VERY SPECIFIC WAYS.

27 min. 02 sec.
SO WE EXPECT THAT THE ABILITY TO LEARN NEW INFORMATION,

27 min. 05 sec.
TO STORE IT AND RETRIEVE IT, WILL BE IMPAIRED             

27 min. 09 sec.
AS ONE OF THE EARLIER SIGNS OF ALZHEIMER'S DISEASE.

27 min. 12 sec.
MRS. SCULLY, I’M GOING TO READ YOU A SHORT PARAGRAPH,                

27 min. 16 sec.
AND WHEN I’M FINISHED,

27 min. 18 sec.
I WANT YOU TO TELL ME AS MUCH OF IT AS YOU CAN REMEMBER.

27 min. 23 sec.
"CRYSTAL LAKE LODGE,

27 min. 25 sec.
2 WOMEN AVOIDED DEATH TODAY WHEN THEIR MOTOR-DRIVEN

27 min. 29 sec.
HOT AIR BALLOON WAS FORCED TO CRASH ON A SNOWY MOUNTAIN

27 min. 34 sec.
20 MILES FROM THE BORDER OF YELLOWSTONE NATIONAL PARK.

27 min. 39 sec.
(JUDITH SAXTON)  WE'RE LOOKING FOR AN EVIDENCE

27 min. 41 sec.
THAT THE INDIVIDUAL CAN TAKE IN NEW INFORMATION, THEN CAN

27 min. 44 sec.
STORE IT FOR A PERIOD OF TIME, AND THEN WHEN ASKED TO CAN             

27 min. 49 sec.
BRING IT BACK INTO CONSCIOUSNESS AND GIVE IT BACK TO US.             

27 min. 52 sec.
I DON'T KNOW IF I COULD EVEN,

27 min. 55 sec.
I DON'T KNOW IF I CAN EVEN REMEMBER ANYTHING.   

27 min. 58 sec.
THERE WAS SOME WOMEN MENTIONED

28 min. 02 sec.
AND WAS IT YELLOWSTONE NATIONAL PARK?

28 min. 07 sec.
(JUDITH SAXTON)  PATIENTS WITH ALZHEIMER'S DISEASE

28 min. 09 sec.
HAVE DIFFICULTY ENCODING THE INFORMATION.

28 min. 11 sec.
IT ISN'T THE CASE THAT THEY GET THE INFORMATION IN,   

28 min. 15 sec.
BUT THEN AFTER 30 MINUTES HAVE LOST IT.   

28 min. 18 sec.
I’M SORRY TO SAY BUT THAT'S ABOUT ALL I REMEMBER.                

28 min. 22 sec.
THEY ACTUALLY NEVER GOT IT IN IN THE FIRST PLACE

28 min. 24 sec.
SO WHEN YOU GO TO RETRIEVE IT, IT ISN'T THERE.             

28 min. 26 sec.
DID I FAIL?

28 min. 28 sec.
NOW DON'T WORRY TOO MUCH ABOUT THAT.

28 min. 31 sec.
IT'S PROBABLY THE BEGINNING OF ALZHEIMER'S, IS THAT IT?

28 min. 34 sec.
WELL, WE ALL WORRY EVERY TIME WE FORGET SOMETHING.

28 min. 37 sec.
WE ALL WORRY EVERY TIME WE CAN'T COME UP WITH A WORD WE WANT,             

28 min. 41 sec.
AND YOU DON'T NEED TO WORRY ABOUT THOSE THINGS NECESSARILY.             

28 min. 44 sec.
THEY ARE UNFORTUNATELY PART OF THE NORMAL AGING PROCESS.

28 min. 47 sec.
I ALWAYS TELL EVERYBODY THEY'RE EVEN ALLOWED ONE MAJOR MESS-UP             

28 min. 52 sec.
SO, FOR EXAMPLE, AND FROM MY OWN MEMORY,

28 min. 56 sec.
LOSING THE CAR IN THE PARKING GARAGE,

28 min. 59 sec.
GOING TO THE ATM MACHINE AND BLANKING ON YOUR NUMBER.

29 min. 03 sec.
BECAUSE THAT HAPPENS TO ME I THINK THAT'S NORMAL.   

29 min. 07 sec.
YOU'RE ALLOWED ONE OR TWO OF THOSE,

29 min. 10 sec.
BUT ONCE THEY REALLY START TO IMPACT YOUR ABILITY TO FUNCTION,              

29 min. 14 sec.
THEN IS THE TIME TO START WORRYING.

29 min. 17 sec.
THE CHANGES ARE VERY SLOW.  YOU KNOW THAT FROM THE WAY
IT CAME ON AND GOT WORSE.

29 min. 21 sec.
(NARRATOR)  THE TESTS MRS. SCULLY TOOK WERE SPECIFICALLY DESIGNED

29 min. 25 sec.
TO SORT OUT THE DIFFERENCES

29 min. 27 sec.
BETWEEN NORMAL AGING AND A MORE SERIOUS PROBLEM.

29 min. 30 sec.
SHE'S HERE WITH HER SON TO GET THE RESULTS.   

29 min. 33 sec.
DO YOU REMEMBER WHEN YOU HAD YOUR TESTING DONE?                

29 min. 37 sec.
YOUR GRADES ARE HERE.

29 min. 38 sec.
[ALL CHUCKLE]   FINAL EXAMS.

29 min. 40 sec.
SO YOU GOT SOME AS AND SOME CS, OKAY.   

29 min. 45 sec.
WE THINK THIS IS EARLY, MILD ALZHEIMER'S DISEASE.

29 min. 49 sec.

29 min. 51 sec.
WE DON'T HAVE A CURE FOR THIS.

29 min. 54 sec.
WE HAVE MEDICINES THAT WE THINK YOU SHOULD START,             

29 min. 57 sec.
WHICH WE HOPE WILL HELP TO SLOW

30 min. 00 sec.
THE CLINICAL PROGRESSION OF THE DISEASE.

30 min. 02 sec.
WE DON'T KNOW WHAT AN EFFECT IT HAS ON THE OVERALL BRAIN CHANGES.

30 min. 07 sec.
WHAT'S THE LONG-TERM PROGNOSIS

30 min. 08 sec.
AS FAR AS HOW LONG DO YOU THINK SHE'LL BE ABLE TO STILL             

30 min. 12 sec.
MAINTAIN HER OWN INDEPENDENT LIVING CONDITIONS, ETC.             

30 min. 15 sec.
THAT'S WHAT I'D LIKE TO KNOW.

30 min. 17 sec.
I THINK SHE'S OKAY FOR NOW,

30 min. 19 sec.
AND WE WOULD REASSESS THIS PROBABLY EVERY 6 MONTHS             

30 min. 21 sec.
AS FAR AS HOW INDEPENDENT CAN SHE BE.

30 min. 24 sec.
BUT DURING THE TIME THAT YOU'RE DOING WELL BY YOURSELF,   

30 min. 27 sec.
SOMEBODY SHOULD BE CHECKING IN.

30 min. 29 sec.
I’M THERE EVERYDAY.

30 min. 31 sec.
YOU'RE FORTUNATE TO HAVE YOUR FAMILY TO BE SO CONCERNED.                

30 min. 33 sec.
WE DON'T ALWAYS HAVE THAT.

30 min. 35 sec.
I ONLY HAD ONE BOY,

30 min. 37 sec.
BUT I’M SURE GLAD I HAD HIM.

30 min. 39 sec.
I PICKED A BIG SIZE THOUGH, YOU NOTICED THAT.

30 min. 42 sec.
(MRS. SCULLY'S SON)  WE WERE VERY CLOSE, SO IT'S TIME FOR ME TO STEP UP    

30 min. 45 sec.
AND DO WHAT I HAVE TO DO TO TAKE CARE OF HER.

30 min. 49 sec.
AND I KNOW IT'S GONNA BE TOUGH, AND THERE'S GONNA BE             

30 min. 52 sec.
SOME BAD TIMES AND SOME TOUGH DECISIONS TO BE MADE.

30 min. 54 sec.
I JUST PRAY THAT I HAVE THE STRENGTH

30 min. 57 sec.
TO MAKE THE RIGHT ONE, THAT'S ALL.

30 min. 59 sec.
(NARRATOR)  RIGHT NOW THERE IS NO TREATMENT THAT WILL STOP ALZHEIMER'S   

31 min. 04 sec.
AND NO PROVEN WAY TO PREVENT IT.

31 min. 08 sec.
BUT AT 29 ALZHEIMER'S DISEASE RESEARCH CENTERS IN THE U.S.,                

31 min. 12 sec.
SCIENTISTS ARE SEARCHING FOR A WAY

31 min. 15 sec.
TO STOP THIS FEROCIOUS DISEASE.

31 min. 18 sec.
(DR. STEVEN DEKOSKY)  IF YOU COULD SLOW THE DISEASE DOWN

31 min. 22 sec.
OR DELAY ITS EMERGENCE FOR 5 YEARS,

31 min. 26 sec.
BECAUSE OF THE LATE AGE AT WHICH THE DISEASE OCCURS,

31 min. 29 sec.
YOU COULD DECREASE BY 50% THE NUMBER OF PEOPLE

31 min. 33 sec.
WHO WOULD HAVE THE DISEASE 40 YEARS LATER.

31 min. 35 sec.
IF YOU COULD DELAY IT BY 10 YEARS,

31 min. 38 sec.
YOU WOULD VIRTUALLY WIPE THE DISEASE OUT

31 min. 39 sec.
BECAUSE THE VAST MAJORITY OF PEOPLE WHO GET IT,             

31 min. 42 sec.
GET IT WITHIN 10 YEARS OF THE END OF THEIR LIFE

31 min. 45 sec.
FROM OTHER REASONS, FROM OTHER CAUSES.

31 min. 47 sec.
SO THOSE ARE RIGHT NOW STILL OUR TARGETS.   

31 min. 51 sec.
(NARRATOR)  THE TARGETS INSIDE THE BRAIN ARE  THE PLAQUE DEPOSITS.

31 min. 55 sec.
RESEARCHERS THINK THEY START TO FORM

31 min. 58 sec.
LONG BEFORE THERE'S ANY NOTICEABLE FORGETTING.

32 min. 01 sec.
SO IF THEY COULD FIGURE OUT A WAY TO PREVENT THEM FROM FORMING                

32 min. 07 sec.
OR TO CLEAR THEM OUT OF THE BRAIN,

32 min. 11 sec.
MAYBE THE CASCADE OF DESTRUCTION COULD BE STOPPED.             

32 min. 15 sec.
BUT BEING ABLE TO SEE PLAQUES INSIDE THE LIVING BRAIN HAS                

32 min. 21 sec.
ELUDED THE GRASP OF SCIENTISTS FOR OVER A CENTURY.             

32 min. 25 sec.
THE PLAQUES ARE ABOUT THE SIZE OF PERHAPS A COUPLE   

32 min. 30 sec.
OF INDIVIDUAL BLOOD CELLS LAID SIDE BY SIDE.

32 min. 34 sec.
SO YOU COULDN'T SEE THEM ON A SCAN.

32 min. 38 sec.
YOU CAN'T SEE TANGLES EITHER

32 min. 40 sec.
BECAUSE THEY'RE INSIDE NEURONS THEMSELVES.

32 min. 43 sec.
BOTH OF THEM ARE WELL BENEATH

32 min. 45 sec.
OUR ABILITY TO MAGNIFY AN MR SCAN.

32 min. 47 sec.
(NARRATOR)  UNTIL SCIENTISTS CAN SEE THE PLAQUES,

32 min. 50 sec.
DEVELOPING DRUGS TAKES YEARS, BECAUSE THE ONLY WAY TO TELL             

32 min. 55 sec.
IF SOMETHING IS WORKING IS TO WAIT AND SEE

32 min. 58 sec.
IF THE PATIENT'S OUTWARD SYMPTOMS GET BETTER OR WORSE.             

33 min. 02 sec.
SO DEKOSKY'S TEAM CAME UP WITH A BOLD PLAN,

33 min. 06 sec.
TO TRY TO CREATE A NEW CHEMICAL COMPOUND

33 min. 09 sec.
THAT THEY COULD GET INSIDE THE BRAINS

33 min. 12 sec.
OF LIVING ALZHEIMER'S PATIENTS,

33 min. 14 sec.
SOMETHING THAT WOULD BIND TO THE PLAQUES

33 min. 17 sec.
SO THAT THEY COULD FINALLY SEE THE INVISIBLE ENEMY.             

33 min. 21 sec.
YOUR MAGIC BULLET WOULD GET INTO THE BRAIN WELL,

33 min. 25 sec.
FIND EXACTLY WHAT IT WANTED, STICK ONLY TO THAT,             

33 min. 29 sec.
AND IF IT WASN'T STUCK THERE, ALL OF IT WOULD LEAVE.             

33 min. 33 sec.
(NARRATOR)  BUT THAT WOULD PROVE TO BE AN ENORMOUS CHALLENGE.   

33 min. 38 sec.
THE BRAIN IS PROTECTED BY AN INTRICATE SYSTEM

33 min. 42 sec.
CALLED THE BLOOD BRAIN BARRIER.

33 min. 44 sec.
IT'S DESIGNED TO KEEP

33 min. 46 sec.
MOST OF THE SUBSTANCES THAT ENTER THE BODY

33 min. 50 sec.
OUT OF THE DELICATE BLOOD VESSELS IN THE BRAIN.

33 min. 54 sec.
MOST MOLECULES ARE EITHER TOO LARGE OR

33 min. 57 sec.
THE WRONG CHEMICAL COMPOSITION TO GET INTO THE BRAIN.             

34 min. 02 sec.
SO THE NEW COMPOUND WOULD HAVE TO BE SOMETHING

34 min. 06 sec.
NEVER ACHIEVED BEFORE, A PERFECT BALANCE OF INGREDIENTS THAT             

34 min. 10 sec.
COULD GET INSIDE THE BRAIN AND FIND ITS TARGET, THE PLAQUES.             

34 min. 15 sec.
AND THERE WAS ANOTHER CRITICAL ISSUE-- TIMING.   

34 min. 18 sec.
THE COMPOUND WOULD HAVE TO STAY IN THE BRAIN LONG ENOUGH             

34 min. 22 sec.
FOR DOCTORS TO DO A SCAN THAT WOULD SHOW THE PLAQUES.

34 min. 27 sec.
BUT THEN IT HAD TO CLEAR OUT OF THE BRAIN QUICKLY

34 min. 31 sec.
TO BE SAFE ENOUGH TO USE ON LIVING PATIENTS.

34 min. 34 sec.
(DR. STEVEN DEKOSKY)  THE TRAPEZE ACT OF MAKING A COMPOUND LIKE THIS,

34 min. 39 sec.
TO GET IT IN, TO GET IT TO STICK, STAY THERE

34 min. 43 sec.
LONG ENOUGH TO LIGHT UP, AND THEN GET OUT IS INCREDIBLE.

34 min. 47 sec.
(NARRATOR)  FOR ALMOST 10 YEARS,

34 min. 49 sec.
THE SMALL GROUP OF CHEMISTS AT THE UNIVERSITY OF PITTSBURGH             

34 min. 54 sec.
TESTED HUNDREDS OF COMPOUNDS,

34 min. 56 sec.
AND ONE AFTER THE OTHER, THEY FAILED.

35 min. 00 sec.
BUT DEKOSKY'S TEAM WAS DETERMINED             

35 min. 02 sec.
BECAUSE THEY KNOW THAT THE ONLY WAY TO STOP THE COMING EPIDEMIC             

35 min. 07 sec.
IS TO SPEED UP THE PROCESS OF FINDING EFFECTIVE DRUGS.

35 min. 11 sec.
AND THE ONLY WAY TO DO THAT IS

35 min. 14 sec.
TO BE ABLE TO SEE WHAT'S REALLY HAPPENING INSIDE THE BRAIN.             

35 min. 19 sec.
(DR. WILLIAM KLUNK)  IF YOU CAN SEE THE ENEMY AND YOU KNOW WHAT IT'S DOING,   

35 min. 24 sec.
YOU CAN BEGIN TO SEE HOW YOUR WAR AGAINST IT IS WORKING.   

35 min. 29 sec.
I’M HOPING THAT THIS WILL LEAD TO A MUCH MORE SUCCESSFUL ERA             

35 min. 33 sec.
IN TREATMENT OF EARLY DIAGNOSIS

35 min. 35 sec.
OF LEARNING HOW TO PREVENT THE DISEASE

35 min. 38 sec.
WHICH, AS WE KNOW IN ALL OF MEDICINE,

35 min. 41 sec.
IS A MUCH BETTER PLACE TO BE THAN TREATING THE DISEASE.

35 min. 45 sec.

35 min. 47 sec.
[CREAKING]

35 min. 50 sec.
(HARRY)  PUSH HIM FOR A LITTLE BIT.

35 min. 52 sec.
(GLADYS) HUH? (HARRY) PUSH HIM.

35 min. 54 sec.
(NARRATOR)  AS GLADYS FUGET

35 min. 55 sec.
MOVES INTO THE MIDDLE STAGES OF ALZHEIMER'S,

35 min. 57 sec.
THE CHANGES IN HER BRAIN

35 min. 59 sec.
ARE CAUSING CHANGES IN HER PERSONALITY,

36 min. 01 sec.
AND IT'S TAKING A TOLL ON HER FAMILY.   

36 min. 04 sec.
(HARRY)  THE REAL MOMENT THAT PUTS ME CLOSE TO THE EDGE

36 min. 10 sec.
IS WHEN SHE AND OUR GRANDSON GET TO LOGGERHEADS.

36 min. 15 sec.
WHY YOU STOP?

36 min. 16 sec.
GET ON OUTTA MY WAY! YOU ALWAYS TRY TO KNOW EVERYTHING

36 min. 19 sec.
AND DON'T KNOW NOTHIN'.

36 min. 21 sec.
I DON'T WANNA PUSH YOU.

36 min. 22 sec.
I DO NOT WANT HIM PUSHIN' ME, I DON'T WANT HIM DOIN' ANYTHING.

36 min. 26 sec.
(HARRY)  GLADYS IS OPERATING AT THE LEVEL OF A 4-YEAR-OLD

36 min. 30 sec.
AND WANTING HER WAY.

36 min. 31 sec.
MY BIG CONCERN IS THAT HE CAN'T UNDERSTAND WHY HIS GRANDMOTHER                

36 min. 36 sec.
WILL LOVE HIM ONE MINUTE AND THEN FUSS IN ANOTHER.   

36 min. 40 sec.
I’M NOT GONNA SWING.

36 min. 41 sec.
COULD YOU PUSH ME?

36 min. 43 sec.
NO, I’M NOT PUSHIN' YOU.

36 min. 45 sec.
LOOK, SHE'S NOT GONNA PUSH ME!

36 min. 47 sec.
(HARRY)  AND HOW DO I CONVINCE HIM THAT HIS GRANDMOTHER STILL LOVES HIM   

36 min. 54 sec.
AND THAT IT'S NOT REALLY HER FAULT THAT SHE IS THAT WAY?               

37 min. 00 sec.
I'LL SPANK YOUR BEHIND.

37 min. 02 sec.
NO, YOU'RE NOT.  I'LL BE GONE BY THEN.

37 min. 05 sec.
I'LL DISAPPEAR MYSELF.

37 min. 07 sec.
YOU CAN'T DISAPPEAR.

37 min. 08 sec.
I CAN DISAPPEAR!

37 min. 10 sec.
YOU CAN'T DO NOTHIN' BUT RUN YOUR UGLY MOUTH.   

37 min. 12 sec.
YES, I CAN. I BE BIG.

37 min. 14 sec.
I DON'T LIKE HIM.

37 min. 16 sec.
AND I DON'T
LIKE HER EITHER.

37 min. 18 sec.
LIAR!

37 min. 20 sec.
DON'T YOU CALL ME NO LIAR.

37 min. 22 sec.
(HARRY)  I FEEL SORRY FOR HIM, AND I’M SORRY FOR

37 min. 25 sec.
THE KIND OF LASTING IMPRESSION IT MAKES ON HIS MIND.

37 min. 29 sec.
(GLADYS)  CHRIS, DID YOU HEAR ME CALL YOU?

37 min. 32 sec.
(HARRY)  SEE WHAT YOUR GRANDMOTHER WANTS.

37 min. 34 sec.
I’M NOT REALLY SURE WHAT WOULD SET IT OFF IN A GIVEN SITUATION.                

37 min. 38 sec.
NOW WHAT DID I WANT?

37 min. 40 sec.
I DON'T KNOW.

37 min. 42 sec.
YOU SAY YOU KNOW.

37 min. 44 sec.
YOU DON'T KNOW NOTHIN'.

37 min. 47 sec.
BUT YOU JUST A SMART MOUTH.

37 min. 49 sec.
AND THERE'S NO WAY THAT I CAN PREDICT

37 min. 52 sec.
WHEN SUCH A THING WILL OCCUR.

37 min. 54 sec.
(GLADYS) NO! [CHRIS CRIES]

37 min. 56 sec.
GO GET YOUR BIKE.  C'MON, C'MON, C'MON.

37 min. 58 sec.
(HARRY)  THE BIGGEST STRESS I HAVE IS WHEN IT DOES OCCUR,   

38 min. 02 sec.
HOW DO I RESOLVE IT?  HOW DO I CALM HER DOWN?

38 min. 07 sec.
HOW DO I CALM HIM DOWN?

38 min. 09 sec.
RIGHT AFTER IT'S OVER, SHE'LL FORGET WHAT CAUSED IT

38 min. 14 sec.
AND BE UNHAPPY, AND SHE WAS THE ONE THAT DID IT.

38 min. 19 sec.
IT FEELS LIKE YOU'RE ON A CONSTANT TREADMILL,   

38 min. 23 sec.
BUT THERE'S NO ESCAPE, YOU KNOW, THERE'S NO WAY OUT.

38 min. 26 sec.
BUT HE'S NOT GONNA DO IT, NOT IF HE'S GONNA STAY HERE, HE'S NOT.             

38 min. 30 sec.
(DR. STEVEN DEKOSKY)   EVERYBODY HANDLES THIS IN A DIFFERENT WAY.   

38 min. 32 sec.
PART OF THE REASON THAT HE'S HAVING THE RESPONSE HE'S HAVING                

38 min. 35 sec.
IS THIS IS NEW BEHAVIOR FOR HER.

38 min. 37 sec.
OF COURSE IT'S CAUSED BY THE DISEASE.   

38 min. 39 sec.
BUT HIS BEHAVIOR IS GOING TO HAVE TO CHANGE AS WELL.   

38 min. 42 sec.
(FEMALE GROUP FACILITATOR)  I WANT TO WELCOME EVERYONE TO
THE ROAD AHEAD SUPPORT GROUP.   

38 min. 45 sec.
THIS IS OUR FIRST MEETING OF THE NEW YEAR.

38 min. 48 sec.
(NARRATOR)  EVERY FAMILY HIT BY ALZHEIMER'S

38 min. 50 sec.
FACES STRESS UNIQUE TO THE DISEASE.

38 min. 53 sec.
TO HELP FACE THESE PRESSURES,

38 min. 55 sec.
HARRY AND GLADYS EACH COME TO THEIR OWN SUPPORT GROUPS.   

38 min. 59 sec.
IT SAYS, "LIFE IS FULL OF CHANGES."

39 min. 01 sec.
SO WHY DON'T WE TALK ABOUT CHANGES.   

39 min. 04 sec.
HOW HAVE THINGS CHANGED IN YOUR FAMILY?   

39 min. 06 sec.
WHAT BOTHERS ME A LOT IN DEALING WITH THIS IS THE STRESS I FEEL                

39 min. 11 sec.
IF I GO OUT AND LEAVE HIM AT HOME.   

39 min. 14 sec.
I ALWAYS CALL HIM, AND IF HE DOESN'T ANSWER THE PHONE,             

39 min. 16 sec.
THEN I DROP EVERYTHING AND GO BACK HOME AGAIN.

39 min. 18 sec.
SO THAT'S THE BIGGEST CHANGE.

39 min. 20 sec.
(FACILITATOR)  DO OTHERS OF YOU WORRY

39 min. 22 sec.
ABOUT LEAVING YOUR FAMILY MEMBER ALONE?

39 min. 24 sec.
(HARRY)  YEAH, I DON'T LEAVE HER.

39 min. 26 sec.
I DRAG HER WITH ME OR PALM HER OFF ON MY DAUGHTER.   

39 min. 28 sec.
[FACILITATOR)  DRAG HER WITH YOU? [ALL LAUGH]

39 min. 31 sec.
HARRY, HAS SOMETHING HAPPENED

39 min. 33 sec.
THAT MADE YOU REALIZE YOU CAN'T LEAVE HER ALONE SAFELY?             

39 min. 38 sec.
A COUPLE MONTHS AGO, WE HAD TO TAKE THE ELEVATOR

39 min. 40 sec.
UP TO THE DOCTOR'S OFFICE, AND I GOT OUT BEFORE SHE DID,

39 min. 43 sec.
AND I THOUGHT SHE WAS BESIDE ME, AND I LOOKED, SHE WASN'T THERE.             

39 min. 46 sec.
I LOOKED RIGHT BEHIND ME, AND SHE WASN'T THERE.

39 min. 48 sec.
AND I LOOKED AND SAW THE ELEVATOR DOOR CLOSE.   

39 min. 50 sec.
THERE WERE 3 BANKS OF ELEVATORS.

39 min. 52 sec.
AND I STOOD THERE AND STOOD THERE, WAS HOPING

39 min. 54 sec.
THAT SHE'D GET ON THE ELEVATOR AND COME BACK DOWNSTAIRS.

39 min. 57 sec.
AND ONE GENTLEMAN CAME BACK DOWN ON THE ELEVATOR WITH HER,                

40 min. 00 sec.
BUT AFTER THAT I MAKE HER GET ON THE ELEVATOR FIRST

40 min. 03 sec.
AND MAKE HER GET OFF THE ELEVATOR BEFORE I DO.

40 min. 07 sec.
(FACILITATOR)  HOW DO SOME OF THE OTHERS OF YOU

40 min. 10 sec.
MANAGE THOSE SCARY TIMES, THE PANIC TIMES?

40 min. 13 sec.
(WOMAN)  I JUST RANT AND RAVE.

40 min. 15 sec.
I JUST KEEP PRAYING FOR THE STRENGTH TO ACCEPT

40 min. 20 sec.
HIS PERSONALITY 'CAUSE THERE'S A BIG PERSONALITY CHANGE.

40 min. 24 sec.
CAREGIVERS ARE REALLY DOING THE BEST THEY CAN

40 min. 28 sec.
TO CARE FOR THEIR FAMILY MEMBER.

40 min. 31 sec.
THEY DO EVERYTHING RIGHT, AND THE PERSON STILL GETS WORSE.

40 min. 35 sec.
(NANCY)  SO HOW WERE THE HOLIDAYS?

40 min. 38 sec.
GLADYS, DID KIDS COME UP, YOUR DAUGHTERS COME HOME?

40 min. 43 sec.
[WITH DEPRESSED TONE]  OH, THE HOLIDAYS.

40 min. 46 sec.
WE HAVE VERY EARLY STAGE, TO APPROACHING DEAD MIDDLE STAGE--             

40 min. 51 sec.
PEOPLE WHO CANNOT INITIATE CONVERSATION

40 min. 53 sec.
BUT UNDERSTAND WHAT YOU'RE TALKING ABOUT.

40 min. 57 sec.
ON THE SAND, AND THE SEA JUST...

40 min. 59 sec.
(MEG MILLER)  IT WOULD BE LIKE WALKING INTO A FOG

41 min. 04 sec.
AND NOT KNOWING WHAT'S THERE,

41 min. 06 sec.
NOT BEING COMFORTABLE IN THE WORLD

41 min. 08 sec.
THAT THEY WERE SO COMFORTABLE IN.

41 min. 11 sec.
AND IF I GO TO THE GROCERY STORE, I GET INTO TROUBLE.             

41 min. 17 sec.
I WAS THERE 3 HOURS.

41 min. 19 sec.
(NANCY)  OVERWHELMING?

41 min. 21 sec.
VERY OVERWHELMING BECAUSE THEY SWITCHED THE STORE AROUND.                

41 min. 25 sec.
I HAD TO LOOK FOR EVERYTHING.

41 min. 27 sec.
I HAD TO GO TO THE MEAT TRYING TO FIGURE OUT

41 min. 31 sec.
WHAT I’M GOING TO COOK, HOW I’M GOING TO COOK IT. I MEAN. . .             

41 min. 36 sec.
(NANCY) GLADYS, YOU DON'T HAVE TOO MUCH TO DO NOW AROUND THE HOUSE.

41 min. 40 sec.
HARRY DOES A LOT OF YOUR STUFF.

41 min. 42 sec.
(GLADYS)  WELL, HE USED TO. HE DON'T NOW.

41 min. 45 sec.
HE LAZY! [ALL LAUGH]

41 min. 47 sec.
I DO MOST EVERYTHING AROUND THE HOUSE NOW.   

41 min. 49 sec.
(NANCY)  YOU ARE? OH, REALLY.

41 min. 51 sec.
DECIDED TO TAKE THINGS ON, HUH?

41 min. 53 sec.
HOW ABOUT GLADYS, HARRY HOW WAS SHE. . .

41 min. 56 sec.
(HARRY)  SHE'S STILL IN DENIAL.

41 min. 58 sec.
SHE MAINTAINS THAT THE ONLY THING WRONG WITH HER IS ME.                

42 min. 00 sec.
IF SHE COULD GET RID OF ME, SHE'D BE IN PERFECT SHAPE!             

42 min. 03 sec.
SHE NEVER DOES ANYTHING WRONG,

42 min. 05 sec.
AND SHE KNOWS WHERE EVERYTHING IS

42 min. 08 sec.
EXCEPT WHEN I TAKE AND MOVE IT SO THAT SHE CAN'T FIND IT.             

42 min. 13 sec.
(WOMAN)  AND HAROLD DOES THE SAME THING,  AND I’M THE CULPRIT.

42 min. 16 sec.
AND SO FROM DAY TO DAY, FROM MINUTE TO MINUTE, YOU JUST

42 min. 19 sec.
NEVER KNOW WHAT KIND OF A MOOD SWING THEY'RE GONNA BE IN.             

42 min. 22 sec.
MY WIFE TELLS ME I’M VEGETATING. . .[GLADYS LAUGHS]

42 min. 27 sec.
BECAUSE I DO SIT AROUND A LOT.   

42 min. 31 sec.
(WOMAN)  THERE'S A LOT OF TIMES THAT I  REALLY ABSOLUTELY HATE HAROLD,   

42 min. 35 sec.
AND IT'S NOT EVEN THAT I HATE HIM.   

42 min. 38 sec.
I HATE WHAT'S HAPPENING TO HIM.

42 min. 40 sec.
AND THEN I FEEL BAD ABOUT MYSELF

42 min. 43 sec.
BECAUSE I FEEL THAT WAY ABOUT HIM.

42 min. 45 sec.
(WOMAN)  ONE OF THE QUOTES I READ IN THE BOOK, IT SAID

42 min. 48 sec.
"I’M NOT DYING, I’M JUST DISAPPEARING BEFORE YOUR VERY EYES,

42 min. 51 sec.
AND I THOUGHT, THAT'S WHAT IT IS.

42 min. 53 sec.
[WITH MUCH EMOTION]  IT'S LIKE,

42 min. 55 sec.
YOU SEE THAT BLANK. . . LOOK, THAT'S THE WORST.

43 min. 00 sec.
(MAN)  THE FRUSTRATION, NOT KNOWING WHAT WAS HAPPENING     

43 min. 04 sec.
AND HOW THE HELL DO YOU TELL ANYBODY THAT, EVEN YOUR FAMILY.             

43 min. 09 sec.
I MEAN, HOW DO YOU EXPLAIN WHAT'S GOING ON?                

43 min. 12 sec.
(NANCY HAFT)  IN A WAY, I THINK IT'S HARDER ON THE FAMILY

43 min. 16 sec.
BECAUSE THEY ARE AWARE FROM BEGINNING TO END.

43 min. 19 sec.
WITH THE PATIENT, EVENTUALLY THEY DO LOSE THE AWARENESS,             

43 min. 23 sec.
THEY LOSE THE INSIGHT,

43 min. 25 sec.
BUT THE FAMILY CAREGIVER IS THE ONE WHO HAS TO COPE

43 min. 31 sec.
WITH THE DECLINE, WITH THE DETERIORATION AS TIME GOES ON.             

43 min. 35 sec.

43 min. 39 sec.
[PIANO PLAYS SOFTLY]

43 min. 41 sec.
(NARRATOR)  LONELINESS AND DEPRESSION

43 min. 43 sec.
ARE COMMON FOR THE LOVED ONES OF ALZHEIMER'S PATIENTS.

43 min. 48 sec.
THOMAS MCKENNA HAS LIVED ALONE FOR 6 YEARS

43 min. 51 sec.
SINCE HIS WIFE WENT INTO THE NURSING HOME.

43 min. 55 sec.
(MAUREEN MCKENNA)  IT WAS REALLY DIFFICULT FOR HIM.

43 min. 57 sec.
HE HAD TO ADJUST TO DOING THINGS FOR HIMSELF

44 min. 00 sec.
THAT HE NEVER HAD TO DO BEFORE-- LAUNDRY AND CLEANING--             

44 min. 04 sec.
JUST THINGS LIKE THAT HE DIDN'T KNOW HOW TO DO.   

44 min. 08 sec.
AND HE APPRECIATED MY MOTHER SO MUCH MORE BECAUSE HE REALIZED   

44 min. 12 sec.
HOW MUCH SHE HAD BEEN DOING ALL HER LIFE

44 min. 16 sec.
TO RUN THE FAMILY AND TO RUN THE HOUSEHOLD.

44 min. 19 sec.
AND HE WENT THROUGH A DEPRESSION.   

44 min. 22 sec.
HE WOULD GET REALLY DEPRESSED, HE'D GET REALLY MOODY.             

44 min. 25 sec.
HE'D GET ANGRY, YOU KNOW, WHY DID THIS HAPPEN TO ME,   

44 min. 30 sec.
WHY DID THIS HAPPEN TO US,

44 min. 32 sec.
IT SHOULDN'T HAVE HAPPENED TO HER,

44 min. 35 sec.
IT SHOULD HAVE HAPPENED TO ME.

44 min. 37 sec.
(THOMAS)  I MISS HER.

44 min. 39 sec.
I MISS HER FOR TALKIN' TO

44 min. 42 sec.
BECAUSE HER AND I COULD CONVERSE,             

44 min. 45 sec.
YOU KNOW, WE COULD MAKE GOOD CONVERSATION.    

44 min. 49 sec.
SHE COULD TELL ME ABOUT SOMETHING THAT HAPPENED             

44 min. 51 sec.
YEARS AND YEARS AGO, AND I KNEW WHO THEY WERE, AND THERE WAS

44 min. 55 sec.
ALWAYS SOMETHING WE COULD LAUGH AT,

44 min. 57 sec.
OR SOMETHING WE COULD TALK ABOUT.

44 min. 59 sec.

45 min. 01 sec.
(MAUREEN AND HELEN)  HI MOM! HEY MOM.

45 min. 04 sec.

45 min. 07 sec.
HOW ARE YOU?

45 min. 08 sec.
SHE LOOKS COMFORTABLE.

45 min. 10 sec.
YOU HAVE TO GIVE HER A KISS.

45 min. 12 sec.
HI, MOM.

45 min. 14 sec.
IT'S HELEN, CAN YOU HEAR ME?

45 min. 16 sec.
SHE'S SOUND ASLEEP.

45 min. 18 sec.
YEAH, SHE LOOKS PRETTY HAPPY.

45 min. 21 sec.
HEY MOM.

45 min. 22 sec.

45 min. 27 sec.
MOTHER!

45 min. 28 sec.
HELLO, IT'S HELEN.

45 min. 30 sec.
I’M HERE, YOUR FAVORITE DAUGHTER!   

45 min. 32 sec.
[BOTH LAUGH]

45 min. 34 sec.
HERE THAT, MOM.

45 min. 35 sec.
THAT'LL GET HER UP.

45 min. 38 sec.
(HELEN)  WHEN I’M WITH HER,

45 min. 40 sec.
I’M JUST GLAD TO SEE HER.

45 min. 42 sec.
SHE'S THERE, SHE'S WARM,

45 min. 44 sec.
AND I CAN TOUCH HER AND TALK TO HER AND TELL HER THINGS.    

45 min. 46 sec.
YOU KNOW, YOU TREASURE EVERY TIME YOU GO VISIT

45 min. 51 sec.
BECAUSE SHE'S STILL HERE.

45 min. 54 sec.
I THINK SHE'S DREAMING.

45 min. 55 sec.
I WANTED TO SEE YOU,

45 min. 57 sec.
JUST WANT TO SEE YOUR EYES, MOM.

45 min. 59 sec.
(HELEN)  YOU SOMETIMES WONDER IF SHE CAN HEAR YOU,    

46 min. 02 sec.
IF SHE RECOGNIZES YOUR VOICE OR NAMES OR ANYTHING.

46 min. 05 sec.
MOM, CAN YOU HEAR ME IN THERE?

46 min. 09 sec.
SHE DOESN'T.

46 min. 11 sec.
(MAUREEN)  WHEN I HOLD HER HAND,

46 min. 13 sec.
I THINK SHE KNOWS SOMEBODY'S THERE,

46 min. 15 sec.
BUT I DON'T NECESSARILY THINK THAT SHE KNOWS THAT IT'S ME.            

46 min. 17 sec.
ISABEL?

46 min. 18 sec.
I JUST WISH I COULD TALK TO HER.

46 min. 21 sec.
IT'S BEEN SO LONG SINCE I’VE HEARD HER VOICE.    

46 min. 25 sec.

46 min. 27 sec.
(HELEN)  IT'S NOT SURPRISING THAT SHE'S HELD ON

46 min. 31 sec.
BECAUSE SHE'S, WAS A TOUGH WOMAN, BUT I DIDN'T THINK--            

46 min. 35 sec.
IT SEEMS ENDLESS NOW, YOU KNOW.

46 min. 38 sec.
IT COULD BE ANOTHER 10 YEARS, IT COULD BE 20.

46 min. 42 sec.
THAT'S WHY THEY SAY, THE LONG GOOD-BYE,

46 min. 45 sec.
IT'S THE LONGEST.

46 min. 47 sec.

46 min. 51 sec.
[IN BRIGHT TONE] BYE MOM!

46 min. 53 sec.

46 min. 57 sec.
[DOOR CLOSES]

46 min. 59 sec.

47 min. 04 sec.
(NARRATOR)  THE LOSSES OF ALZHEIMER'S

47 min. 07 sec.
ARE INTENSELY PERSONAL,    

47 min. 09 sec.
BUT INCREASINGLY, THERE'S ALSO A PUBLIC FACE TO THE DISEASE.

47 min. 15 sec.
THE LEGENDARY FILM DIRECTOR, OTTO PREMINGER,            

47 min. 19 sec.
DIED OF ALZHEIMER'S.

47 min. 21 sec.
SO DID ACTRESS RITA HAYWORTH,

47 min. 26 sec.
BOXING STAR SUGAR RAY ROBINSON,

47 min. 29 sec.
CHOREOGRAPHER GEORGE BALANCHINE,

47 min. 33 sec.
ARTIST NORMAN ROCKWELL,

47 min. 37 sec.
COMPOSER AARON COPELAND,

47 min. 42 sec.
AND IN AN ANNOUNCEMENT THAT STUNNED THE WORLD,    

47 min. 47 sec.
IN 1994, FORMER PRESIDENT RONALD REAGAN

47 min. 51 sec.
REVEALED HE HAD JUST BEEN DIAGNOSED.

47 min. 54 sec.
(DAVID SCHENK)  REAGAN HAD ALZHEIMER'S DISEASE IN HIS FAMILY,

47 min. 58 sec.
AND LOOKING BACK AT THE JOKES HE MADE IN THE WHITE HOUSE,

48 min. 03 sec.
IT'S CLEAR THAT HE WAS CONCERNED

48 min. 05 sec.
ABOUT THE POSSIBILITY THAT HE MIGHT GET IT.

48 min. 09 sec.
IN ONE OF THE ROUTINE CHECKUPS WITH HIS WHITE HOUSE DOCTOR,                

48 min. 12 sec.
HE STARTED OUT BY SAYING

48 min. 14 sec.
I’VE GOT 3 PROBLEMS I WANTED TO TELL YOU ABOUT TODAY.

48 min. 17 sec.
THE FIRST IS THAT I’M HAVING A LITTLE TROUBLE WITH MY MEMORY,    

48 min. 21 sec.
AND I CAN'T REMEMBER THE OTHER 2.    

48 min. 23 sec.
I THINK REAGAN DID A VERY IMPORTANT THING

48 min. 27 sec.
IN TELLING PEOPLE THAT HE HAD ALZHEIMER'S DISEASE,            

48 min. 31 sec.
AND I THINK THAT IT HELPED PEOPLE COME TO GRIPS WITH            

48 min. 36 sec.
THIS EMERGING PHENOMENON THAT WE'RE ALL GONNA HAVE TO FACE.            

48 min. 41 sec.

48 min. 48 sec.
(NARRATOR)  AT A NURSING HOME IN RURAL PENNSYLVANIA,

48 min. 52 sec.
A FAMILY TRAGICALLY FAMILIAR WITH ALZHEIMER'S            

48 min. 55 sec.
HAS COME TO VISIT.

48 min. 57 sec.
HI. GOOD TO SEE YOU.

48 min. 59 sec.
IT'S GOOD TO SEE YOU.

49 min. 02 sec.
(NARRATOR)  JULIE LAWSON HAS TRAVELED FROM BOSTON

49 min. 06 sec.
WITH HER BROTHER, JOHN NOONAN.

49 min. 09 sec.
YOU WANT TO DANCE?

49 min. 10 sec.
(NARRATOR)  THEY'VE COME TO SEE THEIR SISTER, FRAN,

49 min. 14 sec.
AND HER HUSBAND, STEVE.

49 min. 16 sec.
FRAN IS IN THE ADVANCED STAGES

49 min. 19 sec.
OF A RARE FORM OF ALZHEIMER'S THAT STRIKES EARLY IN LIFE.            

49 min. 24 sec.
SHE'S ONLY 54 YEARS OLD.

49 min. 26 sec.
DADDY!

49 min. 28 sec.
(JULIE)  SHE DIDN'T RECOGNIZE ME INITIALLY.

49 min. 30 sec.
STOP IT!!

49 min. 32 sec.
THEN WHEN JOHN AND I CAME IN TOGETHER,

49 min. 35 sec.
SHE RECOGNIZED US, BUT BARELY.

49 min. 37 sec.
(JULIE) FRAN?

49 min. 39 sec.
I LOVE YOU.

49 min. 41 sec.
I LOVE YOU, FRAN.

49 min. 43 sec.
I LOVE YOU, FRAN.

49 min. 45 sec.
I GOT IT IN.

49 min. 47 sec.
YOU DIDN'T PAY ATTENTION HERE.

49 min. 49 sec.
I’VE GOT IT IN.

49 min. 51 sec.
THE THOUGHTS DON'T LAST LONG.

49 min. 53 sec.
THE THOUGHTS ARE MINUTES.

49 min. 54 sec.
YEAH, IT'S. . .

49 min. 56 sec.
(STEVE)  AND SHE'S GETTING WORSE

49 min. 58 sec.
AND SHE CAN'T KEEP HER ATTENTION ON ANYTHING FOR MORE THAN            

50 min. 01 sec.
A MATTER OF SECONDS, AND IT CAN BE A SPLIT SECOND SOMETIMES.            

50 min. 05 sec.

50 min. 07 sec.
OOAAHHH!

50 min. 08 sec.
[ALL LAUGH HEARTILY]

50 min. 10 sec.

50 min. 14 sec.
YOU THING!
[LAUGHS]

50 min. 16 sec.

50 min. 22 sec.
(JOHN)  WHEN I COULD CONNECT WITH HER THAT WAY

50 min. 26 sec.
AND I COULD HOLD HER FACE, IT ALMOST FEELS LIKE SHE STILL

50 min. 30 sec.
HAS THE EMOTIONAL CONNECTION THAT SHE'S ALWAYS HAD.            

50 min. 33 sec.
BUT ACTUALLY I FELT

50 min. 34 sec.
A LOT OF THE PUSHING AWAY AND THE WHACKING.

50 min. 38 sec.
I FELT WE WERE WATCHING HER KID WITH YOU,

50 min. 40 sec.
BUT SHE DOESN'T KNOW HER STRENGTH,

50 min. 42 sec.
AND SHE DOESN'T KNOW HOW HARD IT IS.

50 min. 44 sec.
[LAUGHING] I LOVE YOU!!

50 min. 46 sec.
YOU KNOW, ONE TIME I THINK YOU'RE GONNA HUG ME

50 min. 49 sec.
AND THEN YOU'RE GONNA PUSH ME AWAY.

50 min. 51 sec.

50 min. 55 sec.
OH, THAT'S A SERIOUS LOOK, WHAT'S THAT ABOUT?

50 min. 58 sec.

51 min. 01 sec.
GO AWAY! JUST. . .  [SPEAKS GIBBERISH]

51 min. 04 sec.

51 min. 05 sec.
(JULIE, WHISPERS)  GENTLE, GENTLE, GENTLE.

51 min. 07 sec.
(JOHN)  FOR ME IT'S BEEN LIKE A ROLLERCOASTER.    

51 min. 10 sec.
GET OUT OF THERE!

51 min. 12 sec.
ONE MINUTE YOU SEE HER GOOFIN' AND LAUGHIN' AND JOKIN',                

51 min. 16 sec.
AND THE NEXT MINUTE IT'S INTENSE.    

51 min. 18 sec.
[SPEAKS GIBBERISH]

51 min. 19 sec.
AAAHHHHH!! HA, HA, AH!

51 min. 22 sec.
(JULIE)  SHE HAS A LOT LESS WORDS NOW.

51 min. 25 sec.
YOU CAN ALMOST SEE HER BRAIN SHUT DOWN.    

51 min. 28 sec.
PEOPLE ASK ME, AND SO, HOW IS YOUR SISTER,

51 min. 32 sec.
AND I THINK, WHAT AM I GOING TO TELL YOU?

51 min. 36 sec.
SHE'S LOSING HER MIND.

51 min. 38 sec.

51 min. 47 sec.
(STEVE)  AND SHE'S SO FAR AWAY, SHE'S NOT THERE.

51 min. 49 sec.
[WHISPERING]  IT'S OKAY, IT'S OKAY, YOU'RE OKAY.

51 min. 53 sec.

51 min. 56 sec.
[WITH MUCH EMOTION]  BUT NOW WHEN I TRY TO GEAR UP TO DRIVE UP HERE,

52 min. 03 sec.
IT'S LIKE GEARING DOWN.

52 min. 05 sec.
IT'S NOT. . .  IT'S NOT SO EASY.

52 min. 08 sec.

52 min. 10 sec.
THIS IS WHAT SHE DIDN'T WANT TO DO.    

52 min. 14 sec.
SHE DIDN'T WANT TO BE LOST IN HER MIND LIKE THIS, TORTURED.

52 min. 20 sec.
[RAPID, SHALLOW BREATHING]

52 min. 22 sec.
[WHISPERS]  YOU'RE SAFE.

52 min. 24 sec.
(JULIE, CRYING)  ALL THE THINGS THAT WOULD

52 min. 26 sec.
MAINTAIN HER DIGNITY AS AN INDIVIDUAL HAVE BEEN LOST.

52 min. 30 sec.
[ORCHESTRA PLAYS IN MINOR TONES]

52 min. 32 sec.
¦
¦

52 min. 38 sec.
WHEN FRAN CAME TO TERMS WITH HAVING ALZHEIMER'S,

52 min. 43 sec.
IT WAS LIKE A FUNERAL.

52 min. 46 sec.
WHEN YOU HAVE A FUNERAL, EVERYBODY GATHERS.            

52 min. 50 sec.
BUT IT WASN'T, 'CAUSE SHE WASN'T DYING.    

52 min. 54 sec.
[WITH MUCH EMOTION]  BUT IT FELT LIKE THERE WAS A DEATH SENTENCE DELIVERED.    

53 min. 01 sec.

53 min. 06 sec.
I’M LOSING MY MIND. . .

53 min. 08 sec.
BUT THE ESSENCE OF A PERSON IS THEIR HEART,

53 min. 12 sec.
AND I HOPE THAT AS I GROW OLDER,

53 min. 15 sec.
I'LL STILL BE ABLE TO LAUGH,

53 min. 17 sec.
AND I'LL STILL BE ABLE TO HUG, AND I'LL STILL KNOW LOVE.            

53 min. 21 sec.

53 min. 26 sec.
SHE KNEW WHAT WAS AHEAD OF HER, SHE KNEW.

53 min. 29 sec.
SHE TOOK EVERYTHING ON AS A CHALLENGE.    

53 min. 32 sec.
I MEAN, SHE FIGURED OUT THAT SHE COULD

53 min. 34 sec.
TAKE DRY ERASE MARKERS AND WRITE ON MIRRORS.

53 min. 37 sec.
SHE'D BE IN THE SHOWER, AND SHE'D HAVE A THOUGHT,

53 min. 41 sec.
AND SHE'D LEAN OUTSIDE THE SHOWER

53 min. 43 sec.
AND WRITE HER THOUGHT DOWN SO THAT WHEN SHE GOT OUT,

53 min. 46 sec.
SHE WOULD HAVE IT, 'CAUSE SHE KNEW THAT IN A SECOND'S MOMENT                

53 min. 51 sec.
HER THOUGHT WOULD BE GONE, AND IT WOULD BE BLANK.

53 min. 54 sec.
IT'S LIKE OH, ALZHEIMER'S PEOPLE FORGET.    

53 min. 57 sec.
IT'S EMPTY!

53 min. 59 sec.
AFTER A BUSY DAY, YOU GO HOME YOU MAYBE SIT            

54 min. 02 sec.
DOWN WITH A DRINK OR A CUP OF TEA OR SOMETHING LIKE THAT

54 min. 05 sec.
AND STILL YOUR MIND RACES, DID I REMEMBER TO DO--

54 min. 07 sec.
DAH, DAH, DAH, DAH, DAH, DAH, DAH, DAH, DAH, DAH

54 min. 09 sec.
YOU KNOW? THAT'S NORMAL.

54 min. 11 sec.
I CAN GO AND SIT AND NOT HAVE A THOUGHT IN MY HEAD.

54 min. 16 sec.
¦
¦

54 min. 23 sec.
(ISABEL)  THIS IS SAD, PROFOUNDLY SAD,

54 min. 25 sec.
THAT I’M GOING TO GO TO GET MY KIDS AT SCHOOL,

54 min. 29 sec.
AND ALL OF A SUDDEN I WON'T KNOW WHERE SCHOOL IS.            

54 min. 32 sec.

54 min. 34 sec.
IT'S NOT WHAT I WANTED AT ALL

54 min. 38 sec.
FOR THEM TO HAVE TO LIVE THROUGH.

54 min. 41 sec.
(NARRATOR)  WHEN THEY WERE GROWING UP,

54 min. 44 sec.
NONE OF THE 10 NOONAN SIBLINGS REALIZED            

54 min. 47 sec.
THAT THEIR LIVES WERE GOING TO BE TURNED UPSIDE DOWN

54 min. 51 sec.
IN A SERIES OF TRAGIC AND CONFUSING EVENTS.

54 min. 54 sec.
IT STARTED WITH THEIR MOTHER, JULIA WHEN SHE WAS ONLY 39.            

55 min. 04 sec.
[GUITAR BAND PLAYS '50S ROCK]

55 min. 06 sec.
¦
¦

55 min. 08 sec.
(JULIE)  MOM WAS ENERGETIC.

55 min. 10 sec.
I CAN REMEMBER CLEANING UP THE YARD ON SATURDAY.    

55 min. 14 sec.
MY BROTHERS WOULD ALL BE DRAGGING OLD LEAVES            

55 min. 17 sec.
FROM THE YARD TO THE FIRE THAT WE HAD GOING.

55 min. 22 sec.
EVERYBODY WAS AROUND AND ACTIVE.

55 min. 25 sec.
(BUTCH NOONAN)  WITH 10 KIDS, A DOG, AND ALWAYS COMPANY,

55 min. 30 sec.
IT WAS CRAZY, BUT IT WAS HAPPY. . .

55 min. 35 sec.

55 min. 37 sec.
YOU KNOW, UP UNTIL MY MOM GOT SICK.    

55 min. 41 sec.
SHE JUST WASN'T HERSELF.

55 min. 43 sec.
SHE WAS SNAPPING AT US ABOUT STUFF WE WERE DOING

55 min. 48 sec.
THAT WAS NORMAL EVERYDAY THINGS,

55 min. 51 sec.
AND MY FATHER WAS MORE ON EDGE.

55 min. 54 sec.
IT WAS JUST GETTING' SCARY.

55 min. 56 sec.
BEING 14, 15, AND 16 YEARS OLD, I HAD NO CLUE.

56 min. 02 sec.
I WAS YOUNG ENOUGH TO BE IN KINDERGARTEN,

56 min. 06 sec.
AND SHE FORGOT ME IN KINDERGARTEN.

56 min. 09 sec.
SHE DIDN'T PICK ME UP.

56 min. 12 sec.
AND IT WASN'T JUST LIKE SHE MISSED AN HOUR.    

56 min. 16 sec.
SHE TOTALLY FORGOT ME.

56 min. 18 sec.
IT WAS PRETTY TRAUMATIZING FOR A LITTLE KID.

56 min. 23 sec.
PEOPLE WERE WONDERING IF SHE WAS HAVING A NERVOUS BREAKDOWN,            

56 min. 27 sec.
IF IT WAS POSTPARTUM DEPRESSION.

56 min. 29 sec.
SHE HAD SHOCK TREATMENTS TO TRY TO HELP

56 min. 33 sec.
SNAP HER OUT OF THE DEPRESSION.

56 min. 36 sec.
THEY FIGURED SHE WAS IN A DEPRESSION.    

56 min. 39 sec.
A DOCTOR FINALLY DIAGNOSED IT, AND WE HAD NO COMPREHENSION            

56 min. 44 sec.
OF WHAT ALZHEIMER'S WAS. . .NONE.

56 min. 47 sec.
SHE DIED OF PNEUMONIA,

56 min. 50 sec.
AND IT ALMOST FELT LIKE WE WERE DONE.    

56 min. 56 sec.
[TAKES A DEEP BREATH]  OKAY, WE'RE DONE.

56 min. 59 sec.
WE DON'T HAVE TO DO THIS AGAIN.

57 min. 03 sec.
AND THEN. . .THEN FRAN CAME DOWN WITH IT,

57 min. 13 sec.
AND THAT'S WHEN WE REALIZED WE'RE NOT DONE.            

57 min. 15 sec.
THAT'S WHEN I REALIZED THE MAGNITUDE OF THIS DISEASE.                

57 min. 19 sec.
THIS IS GONNA HIT US AGAIN.

57 min. 22 sec.
I WANTED TO RUN AWAY.

57 min. 24 sec.
I WANTED TO RUN AWAY; I WANTED TO DISAPPEAR.

57 min. 27 sec.
HERE IT IS, NOW IT'S IN OUR GENERATION,

57 min. 31 sec.
NOW IT'S IN US-- WHO'S NEXT?

57 min. 34 sec.
BUTCH JUST WENT TO THE PHONEBOOK AND STARTING CALLING PLACES.                

57 min. 39 sec.
HE IS THE ONE THAT HOOKED UP WITH MASS GENERAL.                

57 min. 45 sec.

57 min. 48 sec.
(NARRATOR)  THE GENETICS AND AGING UNIT

57 min. 51 sec.
AT MASSACHUSETTS GENERAL HOSPITAL

57 min. 53 sec.
IS ONE OF THE NATION'S LEADING CENTERS

57 min. 55 sec.
SEARCHING FOR AN ANSWER TO THE FUNDAMENTAL QUESTION,    

57 min. 59 sec.
HOW DOES ALZHEIMER'S GET STARTED IN THE FIRST PLACE?                

58 min. 02 sec.
(RUDOLPH TANZI)  IN ALZHEIMER'S DISEASE,

58 min. 05 sec.
THE MAIN THING THAT GOES WRONG IS LOSS OF SYNAPSES.                

58 min. 11 sec.
WHAT'S MOST CRITICAL IN TERMS OF MAINTAINING MEMORY

58 min. 15 sec.
WHEN SYNAPSES ARE LOST IS THAT YOU NEED TO REESTABLISH

58 min. 20 sec.
THESE SYNAPSES USUALLY BY NEIGHBORING NERVE CELLS.            

58 min. 23 sec.
IN ALZHEIMER'S, WHEN YOU LOSE A SYNAPSE AND YOU WANT

58 min. 27 sec.
THE NERVE CELLS NEXT DOOR TO COMPENSATE AND REESTABLISH IT,            

58 min. 31 sec.
WELL, THOSE NERVE CELLS ARE BEING ATTACKED TOO.    

58 min. 35 sec.
(NARRATOR)  MOST SCIENTISTS BELIEVE THE KEY TO THE ATTACK

58 min. 39 sec.
IS THE FORMATION OF PLAQUES.

58 min. 41 sec.
THEY START WITH AN ABNORMAL BUILDUP

58 min. 44 sec.
OF A SUBSTANCE CALLED AMYLOID.

58 min. 47 sec.
AMYLOID OCCURS NATURALLY IN THE BODY IN MANY KINDS OF CELLS,

58 min. 52 sec.
BUT SOMEHOW IN THE BRAIN IT TAKES A TOXIC FORM

58 min. 57 sec.
THAT DESTROYS NERVE CELLS AND ERASES MEMORY.

59 min. 00 sec.
ACTUALLY THAT'S A PRETTY GOOD. . .

59 min. 03 sec.
(NARRATOR)  TANZI WAS A PIONEER IN TRYING TO FIGURE OUT

59 min. 07 sec.
WHAT CAUSED THIS CYCLE OF DESTRUCTION.

59 min. 10 sec.
BUT HE STARTED OUT WORKING ON SOMETHING COMPLETELY DIFFERENT.                

59 min. 14 sec.
(RUDOLPH TANZI)  I GOT INTO ALZHEIMER'S DISEASE

59 min. 17 sec.
BASICALLY 'CAUSE I WAS BUILDING A GENETIC MAP            

59 min. 22 sec.
OF CHROMOSOME #21 STUDYING DOWNS SYNDROME.

59 min. 25 sec.
HONESTLY, I PICKED CHROMOSOME 21

59 min. 27 sec.
'CAUSE IT WAS THE SMALLEST CHROMOSOME,

59 min. 29 sec.
AND AS A STUDENT I THOUGHT I WANTED TO BUILD

59 min. 33 sec.
THE FIRST GENETIC LINKAGE MAP OF A WHOLE CHROMOSOME,

59 min. 37 sec.
AND I SPOKE WITH MY ADVISOR, AND HE SAID

59 min. 40 sec.
WELL PICK THE SMALLEST ONE, YOU'LL FINISH FASTEST.            

59 min. 42 sec.
SO I PICKED CHROMOSOME 21

59 min. 45 sec.
NOT KNOWING WHERE IT WAS GOING TO TAKE ME.

59 min. 49 sec.
(NARRATOR)  WHILE TANZI WAS MAPPING CHROMOSOME 21,

59 min. 52 sec.
HE CAME ACROSS AN INTRIGUING COINCIDENCE.

59 min. 54 sec.
TISSUE SAMPLES FROM BRAINS OF PATIENTS WITH DOWNS SYNDROME

59 min. 58 sec.
ALL HAD THE SAME PLAQUES

1hr. 00 min. 01 sec.
THAT ARE FOUND IN ALZHEIMER'S DISEASE.

1hr. 00 min. 03 sec.
SINCE DOWNS SYNDROME IS CAUSED

1hr. 00 min. 06 sec.
BY AN EXTRA COPY OF CHROMOSOME 21,

1hr. 00 min. 09 sec.
TANZI HAD A HUNCH THAT IF THERE WERE A GENE CAUSING ALZHEIMER'S,                

1hr. 00 min. 14 sec.
IT MIGHT BE ON THAT SAME CHROMOSOME.    

1hr. 00 min. 17 sec.
CHROMOSOME 21, BACK THEN MY BABY.    

1hr. 00 min. 19 sec.
THIS WAS PRE HUMAN GENOME PROJECT,

1hr. 00 min. 21 sec.
AND I HAD THE MAP OF CHROMOSOME 21.

1hr. 00 min. 24 sec.
SO IF IT WAS CHROMOSOME 21,

1hr. 00 min. 27 sec.
I WAS LIKE, OK, I’M GONNA FIND IT THEN-- THAT'S MY CHROMOSOME.            

1hr. 00 min. 31 sec.
SO THESE ARE THE ORIGINAL EXPERIMENTS THAT WERE DONE            

1hr. 00 min. 37 sec.
IN 1885-86 TO ISOLATE THE FIRST ALZHEIMER'S GENE, THE APP GENE.            

1hr. 00 min. 44 sec.
EACH ONE OF THESE LITTLE DOTS REPRESENTS A SPOT            

1hr. 00 min. 48 sec.
ON A PETRIE DISH WHERE YOU MIGHT HAVE THE CORRECT GENE.            

1hr. 00 min. 54 sec.
THIS IS HOW WE DID IT IN THE OLD DAYS.    

1hr. 00 min. 58 sec.
(NARRATOR)  THE TINY SPOTS TURNED OUT TO BE A MAJOR DISCOVERY,    

1hr. 01 min. 02 sec.
A GENE FOR A PROTEIN CALLED APP.

1hr. 01 min. 05 sec.
(RUDOLPH TANZI)  WHAT APP IS NORMALLY DOING IS,

1hr. 01 min. 08 sec.
IF THIS IS THE SURFACE OF A NERVE CELL,

1hr. 01 min. 11 sec.
APP WILL STICK OUT LIKE THIS, AND IT'S INTERACTING            

1hr. 01 min. 15 sec.
WITH OTHER PROTEINS, AND IT CAN BE INVOLVED WITH SYNAPSES            

1hr. 01 min. 19 sec.
TO MAINTAIN SYNAPSES, TO MAINTAIN MEMORIES.

1hr. 01 min. 21 sec.
IT'S PLAYING A VITAL ROLE WITH JUST NERVE CELL INTERACTIONS.            

1hr. 01 min. 25 sec.
AND AFTER AWHILE THIS APP IS NO GOOD.    

1hr. 01 min. 28 sec.
IT HAS TO BE TURNED OVER SO IT WILL GET CLIPPED

1hr. 01 min. 32 sec.
OUTSIDE OF THE SURFACE, AND PART OF IT WILL BE SHED.

1hr. 01 min. 36 sec.
(NARRATOR)  IF THE APP PROTEIN IS CLIPPED IN THE RIGHT PLACE,    

1hr. 01 min. 41 sec.
IT FLOATS OFF HARMLESSLY.

1hr. 01 min. 43 sec.
BUT IN ALZHEIMER'S DISEASE, THE CLIPS HAPPEN

1hr. 01 min. 46 sec.
NOT AT THE SURFACE OF THE CELL BUT JUST ABOVE AND JUST BELOW.            

1hr. 01 min. 51 sec.
THE RESULT IS A TOXIC FRAGMENT CALLED BETA-AMYLOID            

1hr. 01 min. 56 sec.
WHICH STARTS THE RELENTLESS DESTRUCTION OF THE BRAIN.            

1hr. 02 min. 00 sec.
(RUDOLPH TANZI)  IF YOU MAKE TOO MUCH OF THIS AND IT'S ALLOWED TO ACCUMULATE,

1hr. 02 min. 06 sec.
IT WILL EVENTUALLY SEQUESTER TOGETHER

1hr. 02 min. 08 sec.
AND FORM AN AMYLOID PLAQUE

1hr. 02 min. 09 sec.
OR AN AMYLOID DEPOSIT IN THE BLOOD VESSEL.

1hr. 02 min. 12 sec.
(NARRATOR)  IT TURNED OUT THAT THE GENE TANZI FOUND ON CHROMOSOME 21   

1hr. 02 min. 18 sec.
WAS KEY TO A PARTICULARLY VICIOUS FORM OF ALZHEIMER'S            

1hr. 02 min. 22 sec.
THAT STRIKES EARLY IN LIFE.

1hr. 02 min. 24 sec.
IT HAD A MUTATION, A MISTAKE IN ITS DNA SPELLING

1hr. 02 min. 29 sec.
THAT PRODUCED A FLOOD OF BETA-AMYLOID IN THE BRAIN.

1hr. 02 min. 33 sec.
THERE ARE 2 OTHER GENES ON DIFFERENT CHROMOSOMES

1hr. 02 min. 37 sec.
THAT ALSO HAVE A VARIETY OF MUTATIONS

1hr. 02 min. 40 sec.
THAT CAUSE EARLY ALZHEIMER'S.

1hr. 02 min. 42 sec.
THESE MUTATIONS ARE RARE,

1hr. 02 min. 45 sec.
BUT THEY TAUGHT RESEARCHERS A SIGNIFICANT LESSON

1hr. 02 min. 48 sec.
BECAUSE THEY ALL PRODUCE THE SAME DISASTROUS RESULT.

1hr. 02 min. 53 sec.
(RUDOLPH TANZI) SO WHAT WE LEARNED ABOUT THE EARLY ONSET GENES IS

1hr. 02 min. 58 sec.
ALL 150 MUTATIONS DISCOVERED SO FAR DO THE SAME THING.

1hr. 03 min. 03 sec.
THEY INCREASE THE PRODUCTION OF BETA-AMYLOID IN THE BRAIN.

1hr. 03 min. 07 sec.
(NARRATOR) GENETIC MUTATIONS CAUSE

1hr. 03 min. 10 sec.
LESS THAN 5% OF ALL CASES OF ALZHEIMER'S,

1hr. 03 min. 14 sec.
BUT IT WAS THAT FIRST GENE ON CHROMOSOME 21

1hr. 03 min. 19 sec.
THAT WAS THE KEY TO THE NOONAN FAMILY'S TRAGEDY.

1hr. 03 min. 24 sec.
THEIR MOTHER, JULIA, HAD THE MUTATION ON THAT GENE

1hr. 03 min. 28 sec.
WHICH CAUSED EARLY ALZHEIMER'S,

1hr. 03 min. 30 sec.
AND THAT MEANT THAT EACH OF JULIA'S 10 CHILDREN HAD

1hr. 03 min. 34 sec.
A 50/50 CHANCE OF INHERITING THE SAME DEADLY MUTATION.

1hr. 03 min. 38 sec.
AND BY 1996, THERE WAS ALREADY ANOTHER VICTIM.    

1hr. 03 min. 44 sec.
ALMOST AT THE SAME TIME AS FRAN, ANOTHER SISTER, MAUREEN,    

1hr. 03 min. 50 sec.
FOUND OUT SHE HAD ALZHEIMER'S.

1hr. 03 min. 54 sec.
SHE DIED 5 YEARS LATER.

1hr. 03 min. 56 sec.
SHE WAS 58 YEARS OLD.

1hr. 03 min. 59 sec.
NOW JULIE AND HER BROTHERS AND SISTERS ALL HAVE TO LIVE

1hr. 04 min. 04 sec.
WITH THE FACT THAT ANY ONE OF THEM COULD BE NEXT.

1hr. 04 min. 09 sec.
(JULIE)  IT LEAVES YOU FEELING EXTREMELY VULNERABLE.    

1hr. 04 min. 14 sec.
I WORRY ABOUT FORGETTING.

1hr. 04 min. 18 sec.
SOMETIMES I GET ANGRY AND I THINK IS THIS AN OVERREACTION?                

1hr. 04 min. 26 sec.
AND THEN IF IT IS AN OVERREACTION,

1hr. 04 min. 30 sec.
IS THIS THE BEGINNING SIGNS OF ALZHEIMER'S?

1hr. 04 min. 33 sec.
(NARRATOR)  IF JULIE HAS INHERITED THE GENE,

1hr. 04 min. 36 sec.
HER 2 TEENAGE DAUGHTERS MIGHT HAVE TO SEE

1hr. 04 min. 39 sec.
THEIR MOTHER DISAPPEAR JUST AS JULIE DID.

1hr. 04 min. 42 sec.
(JULIE)  I HOPE TO GOD THAT I DON'T HAVE THE GENE.    

1hr. 04 min. 47 sec.
THEY'D HAVE TO GO THROUGH LIVING WITH ME,

1hr. 04 min. 52 sec.
AND THAT. . .THAT'S EXTREMELY PAINFUL TO THINK ABOUT.            

1hr. 04 min. 58 sec.

1hr. 05 min. 04 sec.
(NARRATOR)  THE DISCOVERY THAT THE EARLY-ONSET GENES

1hr. 05 min. 07 sec.
ALL INCREASED BETA-AMYLOID IN THE BRAIN

1hr. 05 min. 10 sec.
WAS A HUGE STEP FORWARD FOR SCIENTISTS.

1hr. 05 min. 13 sec.
ONLY HUMANS GET ALZHEIMER'S.

1hr. 05 min. 16 sec.
BUT PUTTING HUMAN GENES

1hr. 05 min. 18 sec.
INTO THE BRAINS OF MICE MAKES BETA-AMYLOID DEVELOP.            

1hr. 05 min. 23 sec.
THIS GIVES RESEARCHERS AN IMPORTANT TOOL

1hr. 05 min. 26 sec.
IN THE FIGHT AGAINST THE DISEASE.

1hr. 05 min. 29 sec.
BEFORE WE CAN STUDY HUMANS OVER YEARS, WE'LL BE ABLE

1hr. 05 min. 33 sec.
TO STUDY MICE OVER MONTHS BECAUSE THE WHOLE PROCESS

1hr. 05 min. 36 sec.
OF AMYLOID DEPOSITION IN THESE MICE THAT HAVE THE 2 MUTATIONS                

1hr. 05 min. 40 sec.
IS SQUEEZED DOWN TO A SMALL WINDOW OF TIME

1hr. 05 min. 43 sec.
THAT MAKES THIS PRACTICAL TO STUDY.

1hr. 05 min. 45 sec.
(NARRATOR)  BUT BEFORE THEY COULD STUDY BETA-AMYLOID IN MICE,    

1hr. 05 min. 49 sec.
THEY STILL HAD TO FIND THAT MAGIC BULLET, A COMPOUND

1hr. 05 min. 54 sec.
THAT WOULD CROSS THE BLOOD BRAIN BARRIER,

1hr. 05 min. 57 sec.
STICK TO THE PLAQUES, AND CLEAR OUT AGAIN.

1hr. 06 min. 01 sec.
(CHET MATHIS)  AFTER SPENDING 7 OR 8 YEARS WORKING ON SOMETHING,    

1hr. 06 min. 05 sec.
GOING THROUGH HUNDREDS OF COMPOUNDS,

1hr. 06 min. 07 sec.
MOST OF THE THINGS ARE FAILURES.

1hr. 06 min. 09 sec.
WE GET MAYBE ONE SUCCESS OUT OF SEVERAL HUNDRED COMPOUNDS.

1hr. 06 min. 13 sec.
AS MUCH AS ONE ATOM DIFFERENCE BETWEEN SOME OF THESE COMPOUNDS                

1hr. 06 min. 17 sec.
MAKES IT GOOD ENOUGH OR NOT GOOD ENOUGH.    

1hr. 06 min. 20 sec.
(NARRATOR)  AFTER ALMOST 10 YEARS OF PAINSTAKING WORK,

1hr. 06 min. 23 sec.
THEY FINALLY HAD SOMETHING THAT LOOKED GOOD IN THE LAB,    

1hr. 06 min. 27 sec.
AND THEY WERE READY TO TEST IT ON MICE.    

1hr. 06 min. 31 sec.
IN A MINIATURE BRAIN SCANNER,

1hr. 06 min. 35 sec.
A MOUSE WAS INJECTED WITH WHAT DEKOSKY'S TEAM

1hr. 06 min. 41 sec.
NAMED THE "PITTSBURGH COMPOUND."

1hr. 06 min. 45 sec.
THE MOUSE SLEPT THROUGH THE MOMENT

1hr. 06 min. 50 sec.
THEY'D BEEN WAITING FOR FOR 10 YEARS.

1hr. 06 min. 57 sec.
BUT THE COMPOUND DID EXACTLY WHAT THEY'D HOPED,    

1hr. 07 min. 01 sec.
GOT INTO THE BRAIN, STUCK TO THE PLAQUES,

1hr. 07 min. 06 sec.
AND THEN QUICKLY CLEARED AWAY.

1hr. 07 min. 08 sec.
THE FIRST THING YOU SEE THAT'S SO EXCITING TO ME IS YOU CAN SEE                

1hr. 07 min. 13 sec.
THE COMPOUND LEAVE THE BLOOD AND GO INTO THE BRAIN,

1hr. 07 min. 17 sec.
AND THEN YOU CAN SEE IT FINDING THE OUTSIDE OF THE PLAQUE                

1hr. 07 min. 21 sec.
AND WORKING ITS WAY TO THE CENTER.    

1hr. 07 min. 23 sec.
SO WE CAN SEE THE WHOLE PROCESS IS THERE

1hr. 07 min. 27 sec.
IN ONE LITTLE 10-SECOND NUTSHELL.

1hr. 07 min. 29 sec.
(NARRATOR)  THE PITTSBURGH COMPOUND WAS WORKING,

1hr. 07 min. 32 sec.
BUT THE TECHNOLOGY AT DEKOSKY'S LAB

1hr. 07 min. 35 sec.
ONLY SHOWED PLAQUE DEPOSITS THAT WERE BIG

1hr. 07 min. 38 sec.
AND HAD ALREADY DESTROYED PARTS OF THE BRAIN.    

1hr. 07 min. 42 sec.
IF THERE WAS ANY CHANCE THAT THEY COULD

1hr. 07 min. 45 sec.
PREVENT THIS DESTRUCTION, THEY HAD TO BE ABLE TO SEE

1hr. 07 min. 50 sec.
MUCH SMALLER AMYLOID DEPOSITS AND MUCH EARLIER IN THE PROCESS.            

1hr. 07 min. 55 sec.
BACK AT MASSACHUSETTS GENERAL HOSPITAL,

1hr. 07 min. 58 sec.
A POWERFUL MICROSCOPE USING A LASER

1hr. 08 min. 01 sec.
CAN SEE DEEP INSIDE THE LIVING BRAIN.

1hr. 08 min. 05 sec.
SO THE 2 TEAMS STARTED A COLLABORATION,

1hr. 08 min. 10 sec.
THE PITTSBURGH COMPOUND AND THE MASSACHUSETTS MICROSCOPE

1hr. 08 min. 14 sec.
TO SEARCH FOR TINY, INDIVIDUAL AMYLOID PLAQUES.

1hr. 08 min. 19 sec.
THIS WHITE VESSEL IS COATED WITH AMYLOID DEPOSITS.

1hr. 08 min. 22 sec.
THE RED THINGS ARE SENILE PLAQUES LABELED

1hr. 08 min. 25 sec.
WITH THE PITTSBURGH COMPOUND  IN THIS CASE.

1hr. 08 min. 28 sec.
THOSE ARE THE TROUBLEMAKERS.

1hr. 08 min. 29 sec.
WE REALLY TOOK A LEAP,

1hr. 08 min. 31 sec.
PUT A LOT OF TIME AND EFFORT INTO DOING THIS            

1hr. 08 min. 35 sec.
AND TO ACTUALLY HAVE IT WORK WAS JUST AMAZING.

1hr. 08 min. 38 sec.
(NARRATOR)  AND WHAT THEY WANT TO DO NEXT  COULD BE EVEN MORE AMAZING.    

1hr. 08 min. 44 sec.
THEY WILL TRY THE PITTSBURGH COMPOUND IN HUMANS.                

1hr. 08 min. 48 sec.
IF IT WORKS IN THE HUMAN BRAIN, THE STAGE WILL BE SET            

1hr. 08 min. 54 sec.
FOR THE FIRST TIME TO TARGET DRUGS DIRECTLY TO BETA-AMYLOID            

1hr. 08 min. 59 sec.
AND POSSIBLE TO STOP ALZHEIMER'S IN ITS EARLIEST STAGES.            

1hr. 09 min. 03 sec.
(DR. BRAD HYMAN)  IT WOULD REVOLUTIONIZE ALZHEIMER'S DISEASE.

1hr. 09 min. 06 sec.
BY BEING ABLE TO DIRECTLY IMAGE THE PLAQUES,            

1hr. 09 min. 09 sec.
WE WILL BE ABLE TO TELL WHEN WE HAVE THERAPIES IN HAND

1hr. 09 min. 13 sec.
WHETHER OR NOT THOSE THERAPIES ARE WORKING.            

1hr. 09 min. 16 sec.
OUR HOPE IS THAT IF YOU COULD STOP AMYLOID DEPOSITION,                

1hr. 09 min. 20 sec.
THAT YOU WOULD PREVENT THE DISEASE,

1hr. 09 min. 22 sec.
THAT PEOPLE WOULD SIMPLY NEVER GET ALZHEIMER'S DISEASE THEN.         

1hr. 09 min. 25 sec.
AND THAT, OF COURSE, IS ALL OF OUR GOAL.

1hr. 09 min. 29 sec.

1hr. 09 min. 33 sec.
(NARRATOR)  REACHING THAT GOAL WON'T CHANGE

1hr. 09 min. 36 sec.
THE INEVITABLE OUTCOME FOR GLADYS FUGET.

1hr. 09 min. 40 sec.
(HARRY)  THE DISEASE IS PROGRESSING,

1hr. 09 min. 42 sec.
AND THE LOSS OF SHORT-TERM MEMORY IS ACCELERATING.                

1hr. 09 min. 46 sec.
SHE STARTED SMOKING AGAIN ABOUT 6 OR 7 WEEKS AGO.

1hr. 09 min. 50 sec.
I WORRY THAT SHE WILL FORGET THAT SHE'S LIT A CIGARETTE                

1hr. 09 min. 54 sec.
AND LET IT BURN AND THEN FALL ON THE CARPET OR FALL IN THE COUCH,                

1hr. 09 min. 59 sec.
AND WE'LL END UP WITH A FIRE.

1hr. 10 min. 01 sec.
BUT SHE INSISTS THAT SHE NEEDS TO SMOKE A CIGARETTE.                

1hr. 10 min. 05 sec.
(GLADYS) WHEN?

1hr. 10 min. 07 sec.
I DON'T SMOKE!

1hr. 10 min. 10 sec.
WHEN?

1hr. 10 min. 12 sec.
YOU HAVE CIGARETTES IN YOUR PURSE NOW.    

1hr. 10 min. 15 sec.
I BET YOU I DON'T, UNLESS YOU PUT 'EM IN THERE.    

1hr. 10 min. 18 sec.
REAL GRASS OVER THERE.

1hr. 10 min. 20 sec.
(HARRY)  IT'S FRUSTRATING ONE DAY AT A TIME.

1hr. 10 min. 23 sec.
SOMETIMES I FEEL THAT I FAILED TO PROPERLY COMPENSATE            

1hr. 10 min. 27 sec.
FOR THE FACT THAT IT'S NOT HER; IT'S THE DISEASE.            

1hr. 10 min. 32 sec.
YOU KNOW, AS LONG AS I REMEMBER THAT, THEN IT'S ALRIGHT.                

1hr. 10 min. 37 sec.
THERE'S STILL SOME PART OF HER THERE

1hr. 10 min. 40 sec.
SO I CAN EXIST WITH THE PART THAT'S THERE

1hr. 10 min. 44 sec.
AND TRY AND KEEP IT THERE AS LONG AS YOU CAN.

1hr. 10 min. 49 sec.

1hr. 10 min. 54 sec.
(NARRATOR)  AS THE EPIDEMIC OF ALZHEIMER'S CONTINUES TO GROW,

1hr. 10 min. 58 sec.
RUDY TANZI'S TEAM IS SEARCHING FOR NEW GENETIC CLUES            

1hr. 11 min. 02 sec.
TO THE COMMON FORM OF THE DISEASE

1hr. 11 min. 05 sec.
WHICH STRIKES IN OLD AGE.

1hr. 11 min. 07 sec.
(RUDOLPH TANZI)  THE QUESTION IS, WHY ONE PERSON GETS TO THE POINT    

1hr. 11 min. 11 sec.
OF HAVING ALZHEIMER'S BY 70 OR 80 YEARS OLD            

1hr. 11 min. 15 sec.
WHEREAS ANOTHER PERSON LASTS UNTIL 90

1hr. 11 min. 17 sec.
WITH BECOMING HARDLY DEMENTED AT ALL.

1hr. 11 min. 20 sec.
SO THE WAY WE ATTACK ALZHEIMER'S IS TO IDENTIFY            

1hr. 11 min. 24 sec.
ALL OF THE GENES THAT CAN CONFER RISK.

1hr. 11 min. 27 sec.
AND REMEMBER, THEY DON'T EVEN ACT INDIVIDUALLY.    

1hr. 11 min. 30 sec.
IN ONE PERSON YOU CAN HAVE 5 OR 6 DIFFERENT RISK FACTORS,    

1hr. 11 min. 35 sec.
GENE-TO-GENE INTERACTIONS,

1hr. 11 min. 36 sec.
ENVIRONMENT TRIGGERING THESE GENES,

1hr. 11 min. 39 sec.
COMPLEX SYSTEMS THAT NEED TO BE WORKED OUT.

1hr. 11 min. 42 sec.
ULTIMATELY THE GOAL WILL BE TO PREDICT EARLY IN LIFE

1hr. 11 min. 46 sec.
WHO IS AT GREATEST RISK FOR ALZHEIMER'S.

1hr. 11 min. 49 sec.
THEN USE THAT INFORMATION TO

1hr. 11 min. 51 sec.
START PRESCRIBING PROPHYLACTIC,  PREVENTATIVE DRUGS,            

1hr. 11 min. 54 sec.
SO THAT WE DON'T EVEN ALLOW THE DISEASE TO STRIKE.

1hr. 11 min. 59 sec.
SO I THINK WE'RE GONNA GET THERE,

1hr. 12 min. 01 sec.
AND I THINK THAT'S THE HOPE FOR ALZHEIMER'S,

1hr. 12 min. 04 sec.
AND IT'S GONNA SERVE AS A MODEL

1hr. 12 min. 06 sec.
FOR MOST OTHER AGE-RELATED DISEASES.

1hr. 12 min. 08 sec.
(WOMAN)  ERIC HAS TAKEN A LEAVE AND THEN JOHN AND I ARE. . .

1hr. 12 min. 12 sec.
(NARRATOR)  DRUGS TO PREVENT ALZHEIMER'S COULD LITERALLY BE LIFESAVERS    

1hr. 12 min. 15 sec.
FOR THE NEXT GENERATION OF THE NOONAN FAMILY.

1hr. 12 min. 17 sec.
ONCE A YEAR THEY COME TO MASSACHUSETTS GENERAL TO MEET WITH TANZI.

1hr. 12 min. 22 sec.
SO I THINK YOU PROBABLY WANT TO HEAR MOST ABOUT WHAT'S

1hr. 12 min. 27 sec.
GOING ON IN THE THERAPY WORLD AND DRUG DEVELOPMENT WORLD.

1hr. 12 min. 30 sec.
(NARRATOR)  THE FAMILY IS PARTICULARLY INTERESTED

1hr. 12 min. 33 sec.
IN AN EXPERIMENTAL VACCINE THAT HAD PROMISING EARLY TRIALS.

1hr. 12 min. 37 sec.
SO YOU KNOW THAT THE VACCINE,

1hr. 12 min. 39 sec.
I WOULDN'T SAY THAT THE VACCINE TRIAL WAS TERMINATED.                

1hr. 12 min. 42 sec.
THAT'S PROBABLY THE WRONG TERM BECAUSE IT WASN'T TERMINATED.                

1hr. 12 min. 45 sec.
THEY STOPPED THE DOSING, 17 PEOPLE OUT OF 300

1hr. 12 min. 48 sec.
HAD A RESPONSE WHERE THE BRAIN, THERE WAS SOME ENCEPHALITIS            

1hr. 12 min. 51 sec.
AND SWELLING OF THE BRAIN, AND SOME OF THOSE PEOPLE DIED.

1hr. 12 min. 55 sec.
SO IT LOOKS LIKE IT'S A T CELL PROBLEM.    

1hr. 12 min. 58 sec.
BUT THAT'S FIXABLE,

1hr. 12 min. 59 sec.
AND I WOULD SPECULATE THAT BY THE END OF THE YEAR,    

1hr. 13 min. 03 sec.
WE'RE GONNA SEE A NEW PHASE-ONE SAFETY TRIAL

1hr. 13 min. 05 sec.
WITH A SAFER VERSION OF THE VACCINE.

1hr. 13 min. 07 sec.
OTHER TRIALS THAT ARE IN THE WORKS--THERE'S CHOLESTEROL,                

1hr. 13 min. 11 sec.
AND YOU KNOW THE CHOLESTEROL-LOWERING DRUGS

1hr. 13 min. 14 sec.
SEEM TO LOWER A-BETA ACCUMULATION.

1hr. 13 min. 16 sec.
THOSE TRIALS ARE ONGOING.  THERE ARE 2 OR 3 GOING ON.

1hr. 13 min. 19 sec.
WE HAVE TO WAIT FOR THOSE.

1hr. 13 min. 21 sec.
SO LOTS OF THINGS GOING ON AT ALL DIFFERENT STAGES,

1hr. 13 min. 24 sec.
AND IT'S JUST GETTING ONE TO CLICK.    

1hr. 13 min. 26 sec.
MY VISION IS WE'LL SEE THIS HAPPEN WITHIN 5 TO 10 YEARS,                

1hr. 13 min. 30 sec.
HOPEFULLY SOONER.

1hr. 13 min. 31 sec.
I HATE THOSE NUMBERS.

1hr. 13 min. 33 sec.
WELL, THE NUMBERS DON'T MAKE SENSE.    

1hr. 13 min. 35 sec.
BUT I MEAN, THE THING IS. . .

1hr. 13 min. 37 sec.
(JULIE)  DO YOU KNOW HOW LONG WE'VE BEEN HEARING 5 TO 10 YEARS?

1hr. 13 min. 41 sec.
YOU KNOW WHY?  BECAUSE THE ORIGINAL, WHO KNEW.

1hr. 13 min. 43 sec.
YOU SEE YOU NEVER KNOW WHAT'S GONNA HAPPEN.    

1hr. 13 min. 45 sec.
YOU'RE NOT THE ONLY PERSON I KNOW
THAT'S SAID 5 TO 10 YEARS.                

1hr. 13 min. 49 sec.
IT'S GUESSWORK.  I MEAN, I MIGHT SAY 5 TO 10.

1hr. 13 min. 51 sec.
SOMEBODY MIGHT HEAR ME SAY THAT AND SAY,  TANZI'S FULL OF CRAP.            

1hr. 13 min. 53 sec.
IT'S GOING TO BE 15 TO 20 YEARS.

1hr. 13 min. 55 sec.
JUST KNOW THERE ARE THOUSANDS AND THOUSANDS OF PEOPLE            

1hr. 13 min. 59 sec.
WORKING 12-HOUR DAYS EVERY DAY TO TRY AND MAKE IT A POSSIBILITY            

1hr. 14 min. 04 sec.
THAT AT SOME POINT THERE'LL BE A GENERATION IN YOUR FAMILY

1hr. 14 min. 08 sec.
WHERE THEY DON'T HAVE TO THINK ABOUT THIS ANYMORE.

1hr. 14 min. 11 sec.
AND I THINK THAT WILL BE A REALITY.    

1hr. 14 min. 15 sec.
IT'S JUST A MATTER OF TIME.

1hr. 14 min. 17 sec.

1hr. 14 min. 19 sec.
(NARRATOR)  IN PITTSBURGH, DEKOSKY'S TEAM WAS ABOUT TO FIND OUT

1hr. 14 min. 23 sec.
IF THEIR YEARS OF WORK ON THE COMPOUND WERE GOING TO PAY OFF.            

1hr. 14 min. 28 sec.
THEY WERE FINALLY READY FOR THEIR FIRST HUMAN TRIALS.    

1hr. 14 min. 32 sec.
FRED NEPP IS A VOLUNTEER WHO DOES NOT HAVE ALZHEIMER'S,    

1hr. 14 min. 36 sec.
BUT HE HAS CONSENTED TO LET THE TEAM

1hr. 14 min. 40 sec.
INJECT HIM WITH THE COMPOUND AND SCAN HIS BRAIN   

1hr. 14 min. 43 sec.
TO SEE IF IT WILL CROSS THE BLOOD BRAIN BARRIER

1hr. 14 min. 47 sec.
AND HOW LONG IT TAKES  TO CLEAR OUT.    

1hr. 14 min. 51 sec.

1hr. 14 min. 52 sec.
¦
¦

1hr. 14 min. 58 sec.
(MAN) START!

1hr. 14 min. 59 sec.
(NARRATOR)  AS SOON AS THE COMPOUND ENTERS MR. NEPP'S VEIN,    

1hr. 15 min. 04 sec.
TINY SAMPLES OF BLOOD ARE TAKEN EVERY 5 SECONDS            

1hr. 15 min. 08 sec.
TO SEE HOW QUICKLY IT'S BEING METABOLIZED.

1hr. 15 min. 11 sec.
AT THE SAME TIME,

1hr. 15 min. 13 sec.
THE PET SCAN IS CONSTANTLY

1hr. 15 min. 16 sec.
MEASURING THE COMPOUND INSIDE HIS BRAIN.

1hr. 15 min. 19 sec.
¦
¦

1hr. 15 min. 25 sec.
THIS IS A CRITICAL MOMENT.

1hr. 15 min. 28 sec.
COMPOUNDS THAT WORK PERFECTLY WELL IN MICE

1hr. 15 min. 31 sec.
OFTEN FAIL WHEN THEY'RE TESTED IN PEOPLE.

1hr. 15 min. 35 sec.
(DR. STEVEN DEKOSKY)  TO SORT OF BE THERE AT THEIR CREATION

1hr. 15 min. 40 sec.
WAS INCREDIBLE--THAT WE COULD TRY THIS IN A LIVING PERSON.            

1hr. 15 min. 45 sec.
¦
¦

1hr. 15 min. 53 sec.
(NARRATOR)  THE BLOOD SAMPLES ARE RUSHED DOWN THE HALL

1hr. 15 min. 57 sec.
FOR IMMEDIATE ANALYSIS IN THE LAB.

1hr. 16 min. 01 sec.
THEY NEED TO KNOW EXACTLY

1hr. 16 min. 03 sec.
WHEN THE COMPOUND REACHES ITS PEAK LEVEL.

1hr. 16 min. 07 sec.
¦
¦

1hr. 16 min. 09 sec.
AND THE RESULTS ARE SPECTACULAR!

1hr. 16 min. 11 sec.
THE FIRST PART OF THE EXPERIMENT WAS A COMPLETE SUCCESS.            

1hr. 16 min. 16 sec.
THE COMPOUND WENT INTO THE BRAIN AND CLEARED OUT SAFELY.            

1hr. 16 min. 21 sec.
BUT THE FINAL MOMENT OF TRUTH CAME WHEN DEKOSKY AND KLUNK            

1hr. 16 min. 27 sec.
SAW PITTSBURGH COMPOUND IMAGES

1hr. 16 min. 29 sec.
FROM INSIDE THE BRAIN OF A PATIENT WITH ALZHEIMER'S.

1hr. 16 min. 34 sec.
(DR. WILLIAM KLUNK) SO WE GOT THESE IMAGES,

1hr. 16 min. 37 sec.
AND I REMEMBER HAVING A REACTION THAT I CAN ONLY DESCRIBE            

1hr. 16 min. 40 sec.
AS MAYBE THE STEELERS SCORING A TOUCHDOWN.

1hr. 16 min. 43 sec.
SO YOU'RE UP, YOU'RE DANCING AROUND!

1hr. 16 min. 45 sec.
I WAS STUNNED! THERE WASN'T ANY DOUBT ABOUT THE INTERPRETATION--            

1hr. 16 min. 47 sec.
IT WAS EXACTLY WHERE IT WAS SUPPOSED TO BE!

1hr. 16 min. 50 sec.
(NARRATOR) THE COMPOUND WORKED IN THE HUMAN BRAIN

1hr. 16 min. 53 sec.
JUST AS WELL AS IT HAD IN MICE.

1hr. 16 min. 56 sec.
FOR THE FIRST TIME EVER,

1hr. 16 min. 58 sec.
THE DOCTORS COULD SEE ACTUAL AMYLOID PLAQUES

1hr. 17 min. 01 sec.
IN A LIVING HUMAN BEING.

1hr. 17 min. 03 sec.
(DR. WILLIAM KLUNK) WE'RE AT THE VERY FIRST STEP OF BEING ABLE

1hr. 17 min. 06 sec.
TO LOOK IN THE BRAIN AND SEEING AMYLOID DEPOSITS.

1hr. 17 min. 09 sec.
THE MORE RED THE COLOR,

1hr. 17 min. 11 sec.
THE MORE OF THE COMPOUND HAS STUCK

1hr. 17 min. 13 sec.
TO THAT AREA OF THE BRAIN WHICH WE ASSUME         

1hr. 17 min. 16 sec.
MEANS THE MORE AMYLOID IS       

1hr. 17 min. 18 sec.
DEPOSITED IN THAT AREA OF THE BRAIN.

1hr. 17 min. 20 sec.
(DR. STEVEN DEKOSKY) IT'S UNBELIEVABLE THAT IT GOT DONE.    

1hr. 17 min. 23 sec.
HE COULD HAVE WORKED FOR 20 YEARS AND NEVER MADE THIS WORK.                

1hr. 17 min. 28 sec.
BUT NOT ONLY TO HAVE IT WORK, BUT SHOW UP LOOKING            

1hr. 17 min. 32 sec.
LIKE A PICTURE YOU PAINTED WAS. . .ABSOLUTELY UNBELIEVABLE.

1hr. 17 min. 36 sec.
(NARRATOR) MANY MORE TESTS OF THE COMPOUND WILL BE NEEDED

1hr. 17 min. 40 sec.
BEFORE IT CAN BE WIDELY USED.

1hr. 17 min. 43 sec.
BUT IT'S A MAJOR TURNING POINT

1hr. 17 min. 45 sec.
IN THE FIGHT AGAINST ALZHEIMER'S.

1hr. 17 min. 48 sec.
IT'S MOST SIGNIFICANT VALUE WILL BE

1hr. 17 min. 50 sec.
TO TEST NEW DRUGS AGAINST AMYLOID IN THE LIVING BRAIN.            

1hr. 17 min. 55 sec.
THE PITTSBURGH COMPOUND IS, I THINK, GOING TO BE ONE OF

1hr. 17 min. 58 sec.
THE MAJOR TOOLS IN TRYING TO FIGURE OUT

1hr. 18 min. 01 sec.
WHETHER OR NOT WE HAVE (A)

1hr. 18 min. 03 sec.
EFFECTIVELY FOUND A WAY TO STOP AMYLOID DEPOSITION,            

1hr. 18 min. 06 sec.
AND (B) CORRELATED THE HALTING OF THAT DEPOSITION            

1hr. 18 min. 09 sec.
WITH SLOWING DOWN OF THE PROGRESSION OF THE DISEASE.            

1hr. 18 min. 13 sec.
[PIANO PLAYS SOFTLY]

1hr. 18 min. 15 sec.
¦
¦

1hr. 18 min. 17 sec.
(NARRATOR) IT'S BEEN 13 YEARS

1hr. 18 min. 20 sec.
SINCE ISABEL MCKENNA WAS DIAGNOSED WITH ALZHEIMER'S.

1hr. 18 min. 24 sec.
WITH EACH PASSING YEAR, HER FAMILY LOSES

1hr. 18 min. 27 sec.
MORE AND MORE OF THE WOMAN THEY LOVE.

1hr. 18 min. 32 sec.
AND THEY KNOW THEY MAY SOON FACE HEART-WRENCHING DECISIONS.                

1hr. 18 min. 36 sec.
SHE WAS COUGHING A LOT AND SWALLOWING A LOT

1hr. 18 min. 40 sec.
AND CHOKING, IT SEEMED LIKE.

1hr. 18 min. 42 sec.
HOPEFULLY SHE WON'T GET PNEUMONIA

1hr. 18 min. 44 sec.
'CAUSE SHE CAN'T SWALLOW ANYMORE.

1hr. 18 min. 47 sec.
HOPEFULLY SHE MIGHT NOT, OR HOPEFULLY SHE WILL.

1hr. 18 min. 50 sec.
(HELEN) WHY? THE PNEUMONIA WOULD WHAT?

1hr. 18 min. 52 sec.
YOU'D HAVE TO THINK ABOUT ANTIBIOTICS

1hr. 18 min. 55 sec.
AND WHAT WE WERE GONNA DO WITH HER.

1hr. 18 min. 58 sec.
I THOUGHT WE HAD DECIDED  THAT WE MIGHT NOT DO THAT.    

1hr. 19 min. 03 sec.
    OH.

1hr. 19 min. 05 sec.
A LONG HAUL, HUH DAD?

1hr. 19 min. 07 sec.
BETTER BELIEVE IT.

1hr. 19 min. 09 sec.
WE'VE ALL TALKED ABOUT WHAT WOULD HAPPEN NEXT.

1hr. 19 min. 13 sec.
I THINK WE'RE ALL IN AGREEMENT THAT IF SHE HAS PNEUMONIA,                

1hr. 19 min. 17 sec.
I DON'T THINK THAT WE WOULD TREAT THAT.    

1hr. 19 min. 21 sec.
I’M SURE I WOULDN'T, AND I’M SURE

1hr. 19 min. 23 sec.
I WOULD HAVE THE SUPPORT OF EVERYONE

1hr. 19 min. 25 sec.
THAT WE WOULDN'T DO THAT TO HER.

1hr. 19 min. 27 sec.
I DON'T THINK THAT'S WHAT SHE WOULD WANT FOR HERSELF,    

1hr. 19 min. 32 sec.
AND I PRAY, I DO PRAY EVERY WEEK,

1hr. 19 min. 36 sec.
THAT YOU KNOW, THIS MIGHT BE THE WEEK.

1hr. 19 min. 41 sec.
I REALLY THINK MAKING THAT DECISION ABOUT

1hr. 19 min. 43 sec.
WHETHER TO TREAT THINGS OR NOT TO TREAT THINGS

1hr. 19 min. 47 sec.
HAS BEEN THE MOST DIFFICULT.

1hr. 19 min. 49 sec.
YOU KNOW WHAT'S RIGHT,

1hr. 19 min. 52 sec.
BUT. . .IT'S YOUR MOM.

1hr. 19 min. 56 sec.
¦
¦

1hr. 20 min. 00 sec.
(HELEN) IT'S SO HARD TO THINK THAT WAY.

1hr. 20 min. 02 sec.
IT'S HARD TO GO TO THAT PLACE

1hr. 20 min. 05 sec.
AND SAY WELL, YOU KNOW, IT'S THE BEST THING.

1hr. 20 min. 08 sec.
AND I JUST THOUGHT OF, YOU KNOW,

1hr. 20 min. 09 sec.
HOW COULD ANYBODY DYING BE THE BEST THING?

1hr. 20 min. 12 sec.
BUT INEVITABLY IT WILL GET WORSE AND WORSE.    

1hr. 20 min. 16 sec.
AT LEAST SHE'S NOT IN ANY KIND OF PAIN.    

1hr. 20 min. 21 sec.
IT SORT OF MAKES ME FEEL, OKAY ABOUT IT, THAT SHE'S STILL HERE.                

1hr. 20 min. 27 sec.
(MAUREEN) KNOWING MY MOTHER AND KNOWING  HOW SHE WOULD HAVE FELT,

1hr. 20 min. 30 sec.
I DON'T THINK SHE WOULD WANT TO BE LIVING THE WAY SHE IS.

1hr. 20 min. 35 sec.
BUT THEN ON THE OTHER HAND, I LOOK AT IT FROM MY DAD

1hr. 20 min. 39 sec.
WHO WANTS TO HAVE HER HERE AND WANTS TO HAVE HER AROUND.

1hr. 20 min. 43 sec.
(THOMAS) I WISH THERE WAS NEVER SUCH A THING.    

1hr. 20 min. 49 sec.
BUT THAT'S LIFE, I GUESS.

1hr. 20 min. 52 sec.
WE HAD A GOOD LIFE TOGETHER.

1hr. 20 min. 56 sec.
WE STOOD BY ONE ANOTHER TOO, IN A LOT OF THINGS.

1hr. 21 min. 02 sec.
50 YEARS-- WE HAD A 50-YEAR WEDDING ANNIVERSARY.    

1hr. 21 min. 07 sec.
COULDN'T BELIEVE IT.

1hr. 21 min. 10 sec.
WE TRIED TO TELL HER THAT, SHE DIDN'T KNOW.

1hr. 21 min. 17 sec.
I WOULD REALLY MISS HER IF SHE WENT.    

1hr. 21 min. 24 sec.
THAT'S THE BIG THING.

1hr. 21 min. 27 sec.
(MAUREEN) I DON'T THINK WE WANT HER TO DIE.    

1hr. 21 min. 32 sec.
I THINK SHE NEEDS TO BE AT PEACE.    

1hr. 21 min. 36 sec.
¦
¦

1hr. 21 min. 49 sec.
[MANY VOICES TALKING AT A FAMILY GATHERING]

1hr. 21 min. 52 sec.

1hr. 21 min. 54 sec.
(NARRATOR) FOR THE NOONAN'S,

1hr. 21 min. 56 sec.
EVERY YEAR THAT GOES BY BRINGS WITH IT

1hr. 21 min. 59 sec.
THE CHANCE THAT ANOTHER ONE OF THEM WILL FALL VICTIM

1hr. 22 min. 03 sec.
TO THE RARE FORM OF ALZHEIMER'S THAT HAUNTS THEIR FAMILY.            

1hr. 22 min. 07 sec.
(MAUREEN) . . .THAT SPAGHTETTI-LOOKING THING?

1hr. 22 min. 09 sec.
YEAH, YEAH, I WAS A CHEF, REMEMBER?.

1hr. 22 min. 11 sec.
(NARRATOR) TONIGHT IS BUTCH'S BIRTHDAY, AND THIS YEAR

1hr. 22 min. 16 sec.
IT'S A PARTICULARLY BITTERSWEET OCCASION.

1hr. 22 min. 20 sec.
MY 3 DIFFERENT CAREERS AND HOW THEY RELATED.

1hr. 22 min. 22 sec.
(BUTCH) I KNEW I WAS HAVING SYMPTOMS ALREADY.    

1hr. 22 min. 25 sec.
I JUST KNOW MY MIND WASN'T WORKING THE WAY IT USED TO.                

1hr. 22 min. 28 sec.
THERE WERE LIKE, BLANK SPACES IN MY MIND.    

1hr. 22 min. 32 sec.
AND I DON'T KNOW HOW TO DESCRIBE IT MUCH MORE THAN THAT            

1hr. 22 min. 38 sec.
EXCEPT FOR, I'D KNOW SOMETHING, BUT IT WASN'T THERE.

1hr. 22 min. 42 sec.
YOU'RE JUST NOT AS QUICK, YOU KNOW?    

1hr. 22 min. 45 sec.
(NARRATOR) BUTCH WAS DIAGNOSED WITH ALZHEIMER'S

1hr. 22 min. 47 sec.
JUST WEEKS BEFORE HIS 51ST BIRTHDAY.

1hr. 22 min. 49 sec.
WELL, I SET MYSELF UP FOR THAT ONE, DIDN'T I?    

1hr. 22 min. 52 sec.
(NARRATOR) HE'S NOW THE 3RD NOONAN SIBLING TO BE STRICKEN.    

1hr. 22 min. 55 sec.
(MAUREEN) THE THING THAT MAKES ME SAD ABOUT BUTCH

1hr. 22 min. 58 sec.
IS TO WATCH THE LOSSES THAT CONTINUE TO GROW

1hr. 23 min. 02 sec.
AND TO LOOK AT HIS WIFE AND KNOW WHAT SHE'S LOSING

1hr. 23 min. 07 sec.
AND TO LOOK AT HIS KIDS

1hr. 23 min. 11 sec.
AND TO KNOW THAT HIS KIDS AREN'T GONNA HAVE A FATHER,

1hr. 23 min. 15 sec.
AND THEY'RE NOT GONNA HAVE A GRANDFATHER

1hr. 23 min. 17 sec.
TO BE PART OF THEIR CHILDREN'S LIVES.

1hr. 23 min. 20 sec.
DID YOU WANT TO SEE ME TODAY?

1hr. 23 min. 23 sec.
     NO.

1hr. 23 min. 26 sec.
BUT WHAT DO YOU GET?

1hr. 23 min. 28 sec.
(BUTCH) THE HARDEST THING IS KNOWING  THAT MY 2 DAUGHTERS

1hr. 23 min. 30 sec.
HAVE A 50% CHANCE OF GETTING THE DISEASE,

1hr. 23 min. 32 sec.
50%-- THAT'S LOUSY ODDS.

1hr. 23 min. 36 sec.
I JUST PRAY THAT THEY DON'T HAVE IT.    

1hr. 23 min. 39 sec.
I JUST PRAY THEY DON'T HAVE IT; I DON'T WANT 'EM TO HAVE IT.            

1hr. 23 min. 44 sec.
YOU KNOW, LET ME BE THE LAST ONE.    

1hr. 23 min. 47 sec.
(HELEN) BUTCH'LL PASS OUT WHEN HE TRIES TO BLOW 'EM OUT!

1hr. 23 min. 52 sec.
(YOUNG BOY) HEY, CAKE COMIN"!

1hr. 23 min. 54 sec.
(ALL) ¦ HAPPY BIRTHDAY TO YOU. ¦

1hr. 23 min. 58 sec.
¦ HAPPY BIRTHDAY TO YOU. ¦

1hr. 24 min. 03 sec.
¦ HAPPY BIRTHDAY DEAR BUTCHIE. ¦

1hr. 24 min. 09 sec.
¦ HAPPY BIRTHDAY TO YOU. ¦

1hr. 24 min. 14 sec.
[LOUD APPLAUSE & CHEERS]

1hr. 24 min. 16 sec.
(BUTCH) I GUESS THE BOTTOM LINE IS I’M IN GOD'S HANDS.

1hr. 24 min. 22 sec.
AND THE MEDICAL COMMUNITY! [LAUGHS]. . .

1hr. 24 min. 25 sec.
AND HOPEFULLY THEY'RE IN GOD'S HANDS!

1hr. 24 min. 28 sec.
"I’M MARRIED TO A 21-YEAR-OLD

1hr. 24 min. 30 sec.
WHO IS GORGEOUS AND ALL OVER ME.

1hr. 24 min. 33 sec.
WHY ARE YOU CRYING?"

1hr. 24 min. 35 sec.
"I CAN'T REMEMBER WHERE I LIVE."

1hr. 24 min. 37 sec.
[VERY HEARTY LAUGH]

1hr. 24 min. 39 sec.
(NARRATOR) BY HIS NEXT BIRTHDAY,

1hr. 24 min. 42 sec.
BUTCH MAY NOT RECOGNIZE EVERYONE HE LOVES.    

1hr. 24 min. 45 sec.
AND LIKE MILLIONS OF OTHER FAMILIES,

1hr. 24 min. 49 sec.
THE NOONANS WILL WATCH AS HIS MIND FADES

1hr. 24 min. 52 sec.
INTO THE DARKNESS OF FORGETTING.

1hr. 24 min. 55 sec.
(BUTCH) I MAKE PLANS FOR THE FUTURE,

1hr. 24 min. 58 sec.
BUT I LIVE FOR TODAY.

1hr. 25 min. 00 sec.
AND I DO THE BEST I CAN WITH EVERY DAY I HAVE,

1hr. 25 min. 05 sec.
BUT I WANT IT TO STOP.

1hr. 25 min. 07 sec.
DO WHATEVER YOU CAN TO SAVE THE NEXT GENERATION,    

1hr. 25 min. 10 sec.
WHETHER IT'S OUR FAMILY OR SOMEBODY ELSE'S FAMILY.    

1hr. 25 min. 13 sec.
STOP THE DISEASE. CURE IT.

1hr. 25 min. 17 sec.
¦
¦

1hr. 25 min. 23 sec.

1hr. 25 min. 24 sec.
¦
¦

1hr. 25 min. 40 sec.
(WOMAN) FIND WHAT YOU NEED TO KNOW ABOUT ALZHEIMER'S

1hr. 25 min. 44 sec.
AT PBS.ORG.

1hr. 25 min. 45 sec.
TALK ABOUT "THE FORGETTING"

1hr. 25 min. 47 sec.
WITH YOUR PBS PROGRAM CLUB

1hr. 25 min. 50 sec.
AND EXPLORE THE LIVING CENTER--

1hr. 25 min. 52 sec.
THE FIRST-EVER HOME ON THE WEB FOR FAMILIES WITH ALZHEIMER'S.       

1hr. 25 min. 56 sec.

1hr. 26 min. 01 sec.
CC- ARMOUR CAPTIONING AND TPT

1hr. 26 min. 03 sec.

1hr. 26 min. 06 sec.
[ORCHESTRA PLAYS]


VO ANNOUNCER: METLIFE FOUNDATION IS PROUD TO SUPPORT THIS PBS PROGRAM ON ALZHEIMER'S DISEASE. AS THE NUMBER OF PEOPLE WITH ALZHEIMER'S INCREASES, IT IS IMPORTANT TO PROVIDE INFORMATION THAT HELPS FAMILIES BETTER UNDERSTAND, PREPARE FOR, AND MEET THE CHALLENGES OF THIS URGENT HEALTH ISSUE. METLIFE FOUNDATION, WORKING TOWARD AN ALZHEIMER'S CURE.

VO ANNOUNCER: THIS PROGRAM WAS ALSO MADE POSSIBLE BY CONTRIBUTIONS TO YOUR PBS STATION FROM VIEWERS LIKE YOU. THANK YOU. 

(WOMAN) THE PROGRAM, "THE FORGETTING,

1hr. 26 min. 27 sec.
IS AVAILABLE ON VHS OR DVD WITH ADDED FEATURES.

1hr. 26 min. 30 sec.
THE BOOK, "THE FORGETTING: ALZHEIMER'S,

1hr. 26 min. 32 sec.
PORTRAIT OF AN EPIDEMIC" BY DAVID SHENK IS ALSO AVAILABLE.   

1hr. 26 min. 35 sec.
TO ORDER CALL. . .

1hr. 26 min. 37 sec.

1hr. 26 min. 41 sec.
(WOMAN)
I AM PBS!