Visit Your Local PBS Station PBS Home PBS Home Programs A-Z TV Schedules Watch Video Donate Shop PBS Search PBS
Rollover text informationAmerican Experience Logo
A Brilliant Madness
The Film and More
Special Features
Online Poll
Game Theory
John Nash
Behind the Scenes
Online Forum

People and Events
Teacher's Guide

spacer above content
Online Forum

Day 1  |  Day 2  |  Day 3  |  Day 4  |  Day 5  |  Day 6

My daughter, who is approaching 43, has paranoid schizophrenia, and appears to be getting worse, even on the new medications. Is this usually a degenerative disease

Diane Moore
Marco Island, Florida

Answered by Irving I. Gottesman, Ph.D.:
The consensus appears to be that schizophrenia is not a degenerative disease, although there are hints that there is some degeneration from autopsy and brain imaging studies. The latter could just be incidental to age.

The appearance of the brain at autopsy (the absence of gliosis) tilts most experts with whom I have talked to favor a neurodevelopmental component which, in concert with genetic predispositions and environmental stressors leads some individuals to develop schizophrenia over a wide age range. Age itself is an independent source of numerous ailments which may add to the worsening of the symptoms of schizophrenia. In an earlier question I answered for this Forum, I also noted that a signficant proportion of patients improve later in life, sometimes without medication, for reasons still unknown.

Periodic medication reviews for type and dosage levels, and even second opinions, are important in the optimal management of all chronic conditions that afflict us. Enough individuals who carry a diagnosis of schizophrenia for many years will then have a manic episode to make it worth noting in the answer to your question; this suggests the presence of bipolar disorder with a necessary switch in medications and a consequent remission. I would also note that one of the consequences of an unrecognized temporal lobe epilepsy is a clinical picture that receives a diagnosis of paranoid schizophrenia; it may take a decade or more for the psychiatric symptoms to appear (see any good textbook of psychiatry).

Irving I. Gottesman

Return to the Online Forum.

Site Navigation

Special Features: Online Poll | Game Theory | John Nash
Behind the Scenes | Online Forum

A Brilliant Madness Home | The Film & More | Special Features | Timeline
Gallery | People and Events | Teacher's Guide

American Experience | Feedback | Search & Site Map | Shop | Subscribe | Web Credits

© New content 1999-2002 PBS Online / WGBH

Exclusive Corporate Funding is provided by: