Can Alzheimer's Be Stopped?

Join investigators as they untangle the cause of Alzheimer’s and race to develop a cure. Airing April 13, 2016 at 9 pm on PBS Aired April 13, 2016 on PBS

Program Description

Alzheimer’s disease strikes at the core of what makes us human: our capacity to think, to love, and to remember. The disease ravages the minds of over 40 million victims worldwide, and it is one of the greatest medical mysteries of our time. Join investigators as they gather clues and attempt to reconstruct the molecular chain of events that ultimately leads to dementia, and follow key researchers in the field who have helped to develop the leading theories of the disease. Along the way, meet individuals from all walks of life who will reveal what it’s like to struggle with Alzheimer’s. Among them, members of a unique Colombian family who have learned that their genetic predisposition all but guarantees early onset Alzheimer’s. Yet there may be hope. Join these courageous patients participating in clinical trials, and then go behind the scenes of the major drug trials to see how researchers target and test therapies that may slow and even prevent Alzheimer’s.

Broadcast Credits

WRITTEN, PRODUCED & DIRECTED BY
Sarah Holt
DIRECTOR OF PHOTOGRAPHY
Stephen McCarthy
EDITED BY
William A. Anderson
MUSIC BY
Sheldon Mirowitz
NARRATED BY
Jay O. Sanders
SCIENTIFIC ADVISORS
Gabrielle Strobel
Bruce Miller
William Mobley
VISUAL EFFECTS & ANIMATION
Jellyfish Pictures
VFX & ANIMATION DIRECTOR
Tom Brass
VFX PRODUCER
Amber Ducker
LEAD VFX ARTIST
Dan Upton
FOR HOLT PRODUCTIONS
CO-PRODUCER
Julie Crawford
ASSOCIATE PRODUCERS
Karinna Sjo-Gaber
Gitanjali Rege
ASSISTANT EDITOR
Michael Quartulli
ADDITIONAL CAMERA
Andreas Bremer
John Chater
Lincoln Else
Lou Weinert
SOUND RECORDISTS
Steve Bores
Adriano Bravo
Francis X. Coakley
Richard Cordoba
John Osborne
Peter Thorneman
ADDITIONAL CREW
Marc Anderson
Robert Barcelona
Nikki Bramley
Andres Toro Giraldo
Ben Lunden
Jacob Sofussen
Diego Sosa
Josh Weinhaus
TRANSLATION
Sally Station
Sonia Perez
ONLINE EDITOR
Evan Schwenterly
COLOR CORRECT AND AUDIO MIX
Henninger Media Services
RESEARCHER
Lillian Steenblik Hwang
 
INTERNATIONAL FIELD ASSOCIATE PRODUCERS
Line Bjerregaard
Maritza Blanco
PRODUCTION ASSISTANTS
Jason Allread
Simon Friis Clemmensen
Cameron Ferguson
John Hassen
Alex Potter
Michelle Tsiakaros
ARCHIVAL MATERIAL
Adrian Merced
Alison Goate
Biogen
Corbis Images
Courtesy of NOVA/WGBH Boston
Eli Lilly and Company
Eric M. Reiman
Genentech
General Electric Company
MedPage Today
MMSE © 2001 by Mini Mental LLC, Inc.; Lic by PAR, Inc.
NBCUniversal Archives
Science Source
Shutterstock
SMUSH Media
SWNS
The Genius of Marian
David Shenk
Steve James
Living with Alzheimer’s Film Project
A Place Called Pluto
SPECIAL THANKS
Bruce Miller
Robert Coulter
Marc Diamond
Matthew Frosch
Goddard House
David Holtzman
Jennifer Manly
Tammy Pozerycki
Rogerson House
Patricia and Jeff Scales
Pierre Tariot
Keith Vossel
Producers gratefully acknowledge the cooperation of Banner Health and its Banner Alzheimer’s Institute, Genentech, Inc., a member of the Roche Group, and the Universidad de Antioquia.
FOR TANGLED BANK STUDIOS
EXECUTIVE DIRECTOR
Dennis Liu
EXECUTIVE IN CHARGE
Sean B. Carroll
EXECUTIVE PRODUCERS
David Elisco
Michael Rosenfeld
DIRECTOR OF OPERATIONS
Lori Beane
GRAPHICS PRODUCER
Anne Tarrant
LINE PRODUCER
Heather Forbes
SENIOR RESEARCHER
Laura Helft
RESEARCHER
Hilary Gerstein
ART DIRECTOR
Fabian de Kok-Mercado
DIRECTOR OF EDUCATIONAL MEDIA
Laura Bonetta
POST PRODUCTION SUPERVISOR
Arjun Rao
PRODUCTION COORDINATOR
Lorri Garcia-Cottrell
NOVA SERIES GRAPHICS
yU + co.
NOVA THEME MUSIC
Walter Werzowa
John Luker
Musikvergnuegen, Inc.
ADDITIONAL NOVA THEME MUSIC
Ray Loring
Rob Morsberger
CLOSED CAPTIONING
The Caption Center
POST PRODUCTION ONLINE EDITOR
Spencer Gentry
DIRECTOR OF PUBLIC RELATIONS
Jennifer Welsh
PUBLICITY
Eileen Campion
Eddie Ward
RESEARCH
Diane Toomey
SENIOR SCIENCE RESEARCHER
Caitlin Rotman Saks
NOVA ADMINISTRATOR
Anne Barleon
PRODUCTION COORDINATOR
Linda Callahan
PARALEGAL
Sarah Erlandson
TALENT RELATIONS
Janice Flood
LEGAL COUNSEL
Susan Rosen
DIGITAL MANAGING PRODUCER
Kristine Allington
SENIOR DIGITAL EDITOR
Tim De Chant
DIRECTOR OF DIGITAL MEDIA
Lauren Aguirre
RIGHTS MANAGER
Lauren Miller
UNIT MANAGER
Ariam McCrary
POST PRODUCTION ASSISTANT
Ezra Wolfinger
POST PRODUCTION COORDINATOR
Brittany Flynn
SUPERVISING PRODUCER
Kevin Young
POST PRODUCTION EDITOR
Michael H. Amundson
BROADCAST MANAGER
Nathan Gunner
BUSINESS MANAGER
Elizabeth Benjes
DEVELOPMENT PRODUCER
David Condon
PROJECT DIRECTOR
Pamela Rosenstein
COORDINATING PRODUCER
Laurie Cahalane
SENIOR SCIENCE EDITOR
Evan Hadingham
SENIOR PRODUCER
Chris Schmidt
SENIOR SERIES PRODUCER
Melanie Wallace
DEPUTY EXECUTIVE PRODUCER
Julia Cort
MANAGING DIRECTOR
Alan Ritsko
SENIOR EXECUTIVE PRODUCER
Paula S. Apsell

A NOVA Production by Tangled Bank Studios, LLC in association with Holt Productions, LLC for WGBH Boston.

© 2016 Tangled Bank Studios, LLC

All rights reserved

Tangled Bank Studios, LLC is a production company established and funded by the Howard Hughes Medical Institute

This program was produced by WGBH, which is solely responsible for its content.

Original funding for this program was provided by Google, Cancer Treatment Centers of America, the David H. Koch Fund for Science, the George D. Smith Fund and the Corporation for Public Broadcasting.

IMAGE:

Image credit (Plaques graphical representation)
© Tangled Bank Studios/Jellyfish Pictures

Participants

Lucía Madrigal
University of Antioquia
Sean Bohen
Genentech
Arthur Canter
Tony Estrella
Alison Goate
Icahn School of Medicine, Mt. Sinai
John Hardy
University College London
Carole Ho
Genentech
Keith Johnson
Massachusetts General Hospital
Kenneth Kosik
University of California, Santa Barbara
Francisco Lopera
University of Antioquia
Conor O'Brien
Greg O'Brien
Mary Catherine O'Brien
Eric Reiman
Banner Alzheimer's Institute
Stephen Salloway
Butler Hospital
Jeff Sevigny
Biogen
Eric Siemers
Eli Lilly and Company
Reisa Sperling
Brigham and Women's Hospital
Shehnaaz Suliman
Genentech
Rudolph Tanzi
Massachusetts General Hospital
Ajay Verma
Biogen
Ryan Watts
Genentech

Resources

Alzheimer’s Association
http://www.alz.org/
Alzheimer’s Disease Education and Referral
http://www.alz.org/
Alzheimer’s Disease Education and Referral Center
http://www.alz.org/
2015 Alzheimer’s Disease Facts and Figures
http://www.alz.org/
Alzforum
http://www.alz.org/
AlzRisk database of environmental risk factors
http://www.alz.org/
Warning signs of Alzheimer’s and how to distinguish it from normal aging
http://www.alz.org/
Database of therapies currently or previously tested as treatments for Alzheimer’s or related disorders
http://www.alz.org/
Worldwide trials registry and results database
http://www.alz.org/
Alzheimer’s disease genetics fact sheet
http://www.alz.org/
Database of genetic association studies in Alzheimer’s
http://www.alz.org/
NIH clinical trials basics
http://www.alz.org/

Preview | 00:30

Full Program | 52:51

Full program available for streaming through

Watch Online
Full program available
Soon