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August 7th, 2009
Spark Blog: Behind the Scenes and Inside the Skulls

The crew films Randy Buckner and Rebecca Saxe in the control room while Alan lies in the MRI machine, having his brain imaged. Photo: Maggie Villiger

By Graham Chedd

Now, I don’t want to get too excited, and I don’t want to give too much away – after all, we want you to watch our shows when they are broadcast. But I think we’ve just seen the first signs of the Human Spark – right inside Alan’s head.

Alan takes a look at the fresh pictures of his own brain. Photo: Larry Engel

We spent the day at MIT’s McGovern Institute, where Alan’s brain was being scanned while doing tasks set for him by MIT’s Rebecca Saxe and Harvard’s Randy Buckner.  Our filming Alan while he’s having his head examined is nothing new, by the way; in the days of Scientific American Frontiers we must have had him in and out of some half dozen MRI machines over the years. In fact, Randy remembered one of those shows, where another Harvard researcher had told Alan that he had a “plump hippocampus,” the brain region involved in helping lay down memories. Randy confirmed Alan’s hippocampus is still plump; in fact, Randy told Alan that he wouldn’t have guessed his age from looking at his brain.

There’s a story behind why we filmed with both Randy and Rebecca, who – while both rising stars in the neuroscience field – are actually working on two apparently unrelated special skills we humans possess. Rebecca has made her name by studying the brain regions involved in thinking about other people, especially thinking about what they are thinking about. Randy, meanwhile, has been studying how we think about the past, and more recently, how we think about the future.

As Rebecca told Alan: “I saw Randy giving a talk about thinking about the past and I looked at these pictures [of the brain] and I thought, ‘that looks really familiar.’ And so I went back to Randy afterward and I said, ‘I’ve got pictures that look a lot like those pictures.’ And so since then we’ve been working together to try to ask: what’s in common? What’s the same about thinking about your own past, your own future, and also other people?”

Well, you’ll have to wait for the answer until The Human Spark is on the air. But I can tell you that Alan had to perform two very different tasks in the scanner. One for Rebecca involved figuring out what a character in a video cartoon was thinking. (Rebecca tested children on the same kinds of social cognition tasks Alan tried. Read about her latest study on how these skills develop as kids mature.) The other for Randy, a word task, actually had nothing to do with what Randy was really looking for – which was what Alan’s brain was doing while he was simply waiting in the scanner, staring at a cross hair and letting his mind wander. What our brains do when we’re doing nothing very much is one of the hottest topics in neuroscience just now. As Randy puts it succinctly: “We think we’re seeing the idle brain not being so idle.”

Rebecca prepares to slide Graham into the MRI for his first ever brain scan. Photo: Larry Engel

I’m going to leave it to you to work out why Alan and the crew found these ideas so exciting, with the not very subtle hint that figuring out what others are thinking on the one hand, and being able to mentally time travel on the other, are two skills which, if not uniquely human, are in humans uniquely powerful. And the discovery that they appear to involve related brain areas – well, Sparks are flying.

As a postscript to the day, Rebecca offered me a chance to have my brain scanned in the McGovern Institute’s very fancy new MRI machine, which looks, by the way, a little like a set for “House.” Now this is something I’ve been given the chance to do many times over the years, going back to not long after MRI machines were invented. I’ve always said no, reasoning that my brain might turn out to be a little less than the perfectly honed machine I’ve always assumed it to be. But this time, inspired by Alan’s pristine hippocampus, I allowed myself to be slid into the tube and tried to think of nothing. You can see the results below.

I have a sneaky feeling Randy thought Alan’s brain looked better.

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  • Patricia A. Alamia

    Hi Alan and researchers,
    My new female medical doctor mentioned at my last visit that she wants to do a MRI on my left shoulder for O. Arthritis-which will be my first experience ever-…but I do not know as of yet if I will agree. I would prefer one done on my brain since I was diagnosed as manic depressive/bipolar since 1982. It amazes me-since accepting my mental illness-that a psychiatrist first labeled me mentally ill w/o a test of some sort. Anyway, I would love to experience a MRI on my brain which makes me disfunctional due to stress…I also wonder why four major meds. must be taken to prevent “episodes” from happening; whereas,
    with stress they do not work sometimes. That’s life!
    I think I will donate my poor brain to science! hehe
    Patsy:)

  • Patricia A. Alamia

    Hi Alan and researchers,
    Just sent a long comment, but it was not accepted; therefore, I’ll try to keep it “short”…

    Wanted to express my predicament with my brain and wondering “why me, Lord???” Then to top it off I have other ailments to deal with such as hypertension, hypothyroidism, hyperlipidemia (chlorestrol), osteoarthritis in left shoulder/left ankle (fell March 3)and kidney failure-stage 3-…!

    I basically survive with the graces of God and a good sense of humor, that is. But, I need to exercise with our dog in the neighborhood sooner rather than later! My weight is a big factor for my health and well being.

    Stress management is also a must, but I feel it may be controlled, but not eliminated due to people and the demands of life.

    At last, I feel that I must set my priorities and have some fun sometimes like I used to and don’t listen to others sometimes. I usually depend on my female doctors now more than ever due to the fact that I am getting older and older. I am now 51 years of age and I for see dying at an earlier age than I expected. No problem here. Patsy:)

  • LILIA

    Alan, I admired your play in the MASH series, now I admire your endeavours in working on the brain research. This is very important, since the human state of mind and how the brain works is the most inaccurate field of medicine. My son is diagnosed with Schizophrenia, I am not sure he has it. Pcychiatry is the most unresearched field up to now. Is it in your plans to research the reason for this illness, what place of brain is the most injured in ill patients? This would be your greates contribution to the science and the mankind. Thank you very much, Alan. Stay healthy, active, and be blessed. I respect you very much and wish you success.

  • kay

    I second that motion Lilia. Good job guys.

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