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PERSPECTIVES:
The Ethics of Xenotransplantation
March 17, 2000    Episode no. 329
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PHOTO OF BOB ABERNETHY BOB ABERNETHY: The first cloned pigs were announced this week in Virginia at a laboratory owned by the same company that cloned Dolly the sheep four years ago. The five piglets were all grown from a single adult cell. In theory, if big transplanting problems can be overcome, organs from cloned pigs -- hearts, livers, kidneys -- could be used someday to replace damaged parts in human beings.

How real is that possibility, and what are the problems, scientific and ethical? Rick Weiss covers biomedical issues for THE WASHINGTON POST.

Rick, welcome. Why does cloning these pigs lead us closer to being able to using pig organs as human transplants?

Mr. RICK WEISS (THE WASHINGTON POST): You know, the biggest scientific hurdle to using these animals as organ donors is that their organs are rejected very quickly by the human immune system. They're just too different. So, in theory, one can design a pig, engineer a pig to be more compatible by adding some genes and taking some genes out of the pig. But it's a lot of work. And once you pull that off, it'd be a lot nicer to be able to clone that transplant donor pig and make thousands of duplicates than to go through all that work over and over for every animal donor that you need.

ABERNETHY: So what we know is if they can solve the rejection problem, then they can do the ...

Mr. WEISS: Right.

PHOTO OF A PIG ABERNETHY: ... the cloning. People worry that parts from an animal might carry with them disease, perhaps very serious diseases.

Mr. WEISS: There are some issues there. Pigs do carry certain kinds of viruses that do not typically live in people. And there are concerns that those viruses, if transplanted into people, might cause disease, or even larger concerns that those viruses might genetically intermingle with human viruses inside a recipient, create new offspring viruses that have never existed before, and perhaps infect people in the general public. It raises an ethical question of whether the public should somehow have a say in whether this person is going to get a transplant.

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ABERNETHY: Yes. And there's some animal rights issues, too. The animal rights people are perhaps ...

Mr. WEISS: Yeah.

ABERNETHY: ... active in this?

Mr. WEISS: Right. There are some concerns about whether this is a new, appropriate use for animals, and the living conditions that these animals would have to be raised in are very special.

PHOTO OF WEISS & ABERNETHY ABERNETHY: What about this, though? There are 68,000 Americans or so who need organs, and not enough organs from humans available. So there's a clear demand. On the other hand, there's something about taking an organ from an animal that might seem to demean our idea of who we are. It might seem to suggest that we're just the sum of our parts.

Mr. WEISS: Mm-hmm. I think a lot of people are having to look within themselves very deeply, as this issue has come up, about how they feel about reaching that barrier. I think what surveys have shown and what I've heard is that when it comes right down to it, in a life-and-death situation, people are willing to cross that line and live with it.

ABERNETHY: Rick Weiss, many thanks.

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