The dioxins present in Agent Orange, the defoliant used in the Vietnam War, continue to leave a legacy of death, deformity, and disability for generations. This investigative documentary includes painstaking historical research and interviews with whistleblowers, researchers, and the people who have lived through contact with the poison in both Vietnam and the United States. The People vs. Agent Orange follows Vietnamese activist Tran To Nga, who, in a French court, is suing the American chemical industry for poisoning her and her family in Vietnam. And in Oregon, Carol Van Strum battles to stop the ongoing spraying of toxins by the timber industry. Both women, joined in their mutual pain, resist intimidation and threats, bringing to light the ongoing, intergenerational catastrophe of chemical warfare and toxic herbicides.