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In 1984, John Rosenberg of the University of Pittsburgh completed
the first visualization of a protein/DNA complex—a molecule of
DNA and a molecule of protein bound together. This complex involved
the EcoR1 protein, an important enzyme that is known to bind to DNA.
Protein/DNA complexes play an important part in many biological
processes. The structure imaged here has helped scientists
understand how protein and DNA molecules recognize each other.
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