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Cyclophosphamide
Brand
Names: Cytoxan, Neosar
What
it is: chemotherapy drug
How
it works: Cyclophosphamide acts by
transferring one or more saturated carbon atoms to cellular macromolecules.
This damages the cancer cell DNA, and slows or stops the growth of the cancer
cells.
Do
not use if one or more is true:
ABC-B2
= +
GSTP1
= +
MT1
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Doxorubicin
Brand
Names: Adriamycin, Rubex
What
it is: chemotherapy drug
How
it works: Doxorubicin inhibits RNA
synthesis and causes DNA strand breakage. This slows or stops the growth of
the cancer cells.
Do
not use if one or more is true:
EGFR
= +
ABC-C6
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Fluorouracil
(5-FU)
Brand
Name: Adrucil
What
it is: chemotherapy drug
How
it works: Fluorouracil binds with
and deactivates a key enzyme (thymidylate synthetase) in thymidine
biosynthesis. This slows or stops the growth of the cancer cells.
Do
not use if one or more is true:
EGFR
= +
BCL2
= +
DPYD
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Methotrexate
Brand
Names: Mexate, Folex
What
it is: chemotherapy drug
How
it works: Methotrexate binds to and
inactivates the enzyme dihydrofolate reductase (DHFR), and inhibits the
synthesis of purine and pyrimidine. This prevents the growth of cancer cells.
Do
not use if one or more is true:
BCL2
= +
DHFR
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Paclitaxel
Brand
Name: Taxol
What
it is: chemotherapy drug
How it works: Paclitaxel binds to tubulin and
blocks cell division. This slows or stops the growth of cancer cells.
Do
not use if one or more is true:
BCL2
= +
ERB-B2
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Tamoxifen
Brand
Name: Nolvadex
What
it is: hormone (antiestrogen)
How it works: Tamoxifen binds to the estrogen
receptor, preventing cell growth. It also affects the cycling of the cell in
the natural cell cycle.
Do
not use if one or more is true:
ESR1
= 0 or ‑
ERB-B2
= +
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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Trastuzumab
Brand
Name: Herceptin
What
it is: monoclonal antibody
How it works: Herceptin binds to the ERB-B2
growth factor receptor and prevents the cell from dividing.
Do
not use if one or more is true:
ERB-B2
= 0 or –
Safe to use for:
Patient 1 yes no
Patient 2 yes no
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