Name: How Does CRISPR Work?
Uploaded: undefined
Duration: undefined

Nova

CRISPR makes gene editing faster, cheaper, and easier than ever before. Here's how.

How does CRISPR work?

the Alfred P. Sloan Foundation

The Gordon and Betty Moore Foundation

The John Templeton Foundation

The National Science Foundation

<div class="rich-text"><p>CRISPR makes gene editing faster, cheaper, and easier than ever before. Here's how.</p>
</div>

<div class="rich-text">CRISPR makes gene editing faster, cheaper, and easier than ever before. Here's how.</div>

How Does CRISPR Work?

Body & Brain

<div class="rich-text"><h3>
 How Does CRISPR Work?
</h3>
<p>
 Published May 23, 2018
</p>
<p>
<strong>
  Andre Fenton:
 </strong>
 CRISPR stands for: clustered, regularly, interspaced, short, palindromic, repeats. That’s why it’s just called “CRISPR”.
</p>
<p>
 First discovered in bacteria, CRISPRs are like bacterial immune systems. They have two key parts: a destroyer protein—like one called CAS 9—and a piece of RNA that matches old viruses that previously infected the bacteria.
</p>
<p>
 If the same virus were to invade again, the RNA would recognize the invader’s DNA, attach itself to its old enemy and its CAS partner would slice the virus’s DNA—destroying it.
</p>
<p>
 A few years ago, some researchers realized they could use CRISPR to edit the genome of any living organism.
</p>
<p>
 Here’s the idea: Say I have a stretch of DNA—maybe a part of a gene—I’d like to change. If I know the sequence of letters there—I can build a CRISPR that carries a matching code.
</p>
<p>
 Once inside the cell—CRISPR will scan the DNA until it finds that exact spot. And when it does, it slices the DNA right there.
</p>
<p>
 Now I have a broken gene…but it turns out, I can now insert a new sequence into the gap, and that makes CRISPR potentially an extremely powerful tool.
</p></div>

Brilliant.org

NOVA Science Trust Logo

Canada

United States

Northern Mariana Islands

Puerto Rico

American Samoa

Guam

U.S. Virgin Islands

U.S. Minor Outlying Islands

US, US Territories, Canada

US & Territories

<p>NOVA investigates the story of cannabis from the criminalization that has disproportionately harmed communities of color to the latest medical understanding of the plant. What risks does cannabis pose to the developing brain? How much do we know about its potential medical benefits? As cannabis becomes socially accepted, scientists are exploring its long-term health consequences. (Premiered September 29, 2021)</p><p>Check out a previously recorded panel discussion and audience Q&amp;A featuring experts and producers from "The Cannabis Question" <a href="https://youtu.be/nSTT5RZ_hxA">here</a>.</p>

<p>As state-legalized cannabis spreads, NOVA explores its little-known risks and benefits.</p>

The Cannabis Question

A 2006 composite image from NASA's Hubble Space Telescope and Spitzer Telescope shows the chaos of baby stars in the Orion nebula some 1,500 light-years away. Image Credit: NASA/JPL-Caltech/STScI

<p>With the upcoming launch of the James Webb Space Telescope, the Hubble era is gradually drawing to a close. Here are some highlights from the countless wonders Hubble has shown us during its 31 years in space.</p>

10 spectacular Hubble Space Telescope images

A statue of Zheng He at the Sam Poo Kong Temple in Java, Indonesia. Image Credit: Budianto Santosa, Shutterstock

<p>In the 1400s, Zheng He sailed thousands of miles around Asia and Africa in ships the size of soccer fields, spreading Chinese innovations like compasses and gunpowder in the process. </p>

Transcript

Credits

Support Provided By