The efforts by congressional Republicans to defund Obamacare over the budget battle, the rollout of the Affordable Care Act's latest provisions on Oct. 1, Obama and Rouhani talk and implications for U.S.-Iran relations, and securing Syria's chemical weapons.Joining Gwen: Gloria Borger, CNN; Karen Tumulty, Washington Post; Doyle McManus, Los Angeles Times and Kimberly Dozier, Associated Press.

On the Webcast Extra, Doyle McManus discusses the role the tea party will play in the 2014 midterm election. Karen Tumulty explores the relationship between West Virginians and the federal government. Plus is Nancy Pelosi really President Obama’s secret weapon? Alexis Simendinger explains their relationship. And Tom Gjelten reports on the drone strike that killed a Taliban leader this week.

On the Webcast Extra: Doyle McManus gives us his impressions of Iranian President Hassan Rouhani. Was his charm offensive at the UN effective? Also, after a terror attack rocks Kenya, our panel analyzes the future of al-Shabaab and whether it poses a threat here in the US. Plus, who is Ted Cruz?

Martha Raddatz reports on the latest in Secretary of State John Kerry’s negotiations with Iran over their nuclear weapons program. James Kitfield discusses the effect of the sequester on the Pentagon budget. And Susan Davis reports on the ongoing budget negotiations between Sen. Patty Murray and Rep. Paul Ryan.

In the Webcast Extra: the conversation continues online as we answer more of the questions our viewers sent in on topics like healthcare and gerrymandering. Also, the panelists analyze the recent Iran nuclear deal.

How the Obama administration plans to fix the Affordable Care Act and how it could stall other second-term legislative priorities; and the recent negotiations and sticking points of a deal to limit Iran’s nuclear program. Joining Gwen: Indira Lakshmanan, Bloomberg News; John Harwood, CNBC/ The New York Times; Dan Balz, Washington Post; Jeff Zeleny, ABC News.

On the Webcast Extra, with the nation's governors in Washington, DC, President Obama hopes to shift focus from national races and issues to the states. But in Wisconsin, investigations into Republican Gov. Scott Walker's first campaign continue. And in Vienna this week talks and negotiations about Iran's nuclear weapons program kicked off.