Koch Foundation

Draper





  
      <div class="rich-text"><p>Sporting a bulbous body, deflated head, and eight tiny caterpillar legs, this creature looks like a toddler’s drawing of a Macy’s Day Parade balloon. But the humble, microscopic tardigrade just might hold the secret to saving countless human lives.</p><p>Also known as a “moss piglet” or “water bear” because of its striking appearance, the tardigrade is no stranger to experimentation. In the name of science, researchers have sent water bears to space, zapped them with X-rays, thrown them into a deep freeze, and heated them to extreme temperatures. And to everyone’s amazement, their <a href="https://www.livescience.com/62720-tardigrade-lifespan.html">tardigrade subjects almost always survived</a>, by resorting to their signature move: hibernation.</p></div>
  

  
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      <div class="rich-text"><p>Experts suggest that these nearly indestructible animals, which are just as at home on a backyard tree as in a sewage treatment plant in Antarctica, might live to see the eventual death of the Sun.</p><p>Most organisms that thrive in extreme conditions do so by producing a special sugar called trehalose, which protects them from drying out. Strangely, most tardigrade species lack this sugar. But they do possess cytosolic-abundant heat soluble (CAHS) proteins, which have been found only in water bears and separate them from Planet Earth’s other extremophiles (organisms capable of surviving in extreme environments). University of North Carolina biologist <a href="https://endeavors.unc.edu/the-survivors/">Dr. Thomas Boothby</a> and his colleagues discovered that when tardigrades are deprived of water, their production of CAHS proteins is kicked into overdrive.</p><p>In extreme conditions, <a href="https://cdr.lib.unc.edu/record/uuid:77b143b8-ec74-49f6-8a3d-6cffe0f81725">CAHS proteins</a> create a 3D gel-like network, which protects tardigrades’ other proteins from unfolding and combining with each other—a process that can lead to cell death. Boothby wondered if CAHS proteins could be recruited to protect vulnerable proteins that humans rely on, such as vaccines and blood in blood banks, both of which are protein-based and need to keep cool to stay viable. Medical experts call the temperature-controlled supply chain of vaccines and other protein-based pharmaceuticals the “cold chain.”</p>
            <figure class="richtext-image full-width"><img alt="Water Bear 2.mov.01_04_58_05.Still001.png" class="richtext-image full-width" height="450" width="800"
            src="/wgbh/nova/media/images/Water_Bear_2.mov.01_04_58_05.Still001.width-800.png"/><figcaption><p>A water bear, as seen through a microscope, munches on waste in a sewage treatment plant at McMurdo Research Station in Antarctica. Image credit: Arlo Perez, WGBH</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>New methods that allow for the safe and stable preservation of cells and bioreagents (biological substances like enzymes) are needed, “particularly when delivering drugs and medicine to inaccessible areas, or to areas that lack an infrastructure to maintain the cold chain,” says <a href="https://spu.edu/academics/college-of-arts-sciences/biology/faculty-staff/tenlen-jenny">Dr. Jenny Tenlen</a>, a biologist at Seattle Pacific University who studies tardigrade development. “Because of tardigrades&#x27; extreme stress tolerance, they have the potential to provide biological solutions to this problem.” About 90 percent of the cost of vaccination programs in developing countries, Boothby adds, comes from the need to keep vaccines cold.</p><p>If tardigrade proteins could protect protein-based pharma, Boothby says, we wouldn’t have to rely on the cold chain to keep vaccines stable. “It might not seem like a big deal to us in a developed world,” he says. “But in other parts of the world, keeping things cold can be a logistical and economic burden.”</p></div>
  

  
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      <div class="rich-text"><p>Now, Boothby and his team are partnering with Cellphire, a biotech company focused on cell stabilization technology, to apply tardigrade proteins to pharmaceuticals. If successful, this research could make it easier to maintain vaccine supplies in developing countries and military zones, both of which can lack reliable access to refrigeration.</p><p>To collect large amounts of CAHS proteins, the team inserts copies of tardigrade genes responsible for making CAHS proteins into bacteria, which are notoriously prolific. “We can grow billions or trillions of bacteria a day and engineer them to make the protein,” Boothby says.</p><p>Converting bacteria into human protein factories is nothing new. The pharmaceutical industry uses them to create everything from insulin to cancer-fighting interferon. Safely extracting a desired protein from its engineered bacterial creators is always vital, Boothby explains, as bacteria can produce a toxic substance called an endotoxin. (To ensure its endotoxin cleanup is thorough, Boothby’s team is conducting immune studies in which CAHS proteins derived from the bacteria are inserted into mice.)</p><p>Already, Boothby and his team have compared tardigrade proteins’ ability to preserve vaccines to that of FDA-approved protectants. CAHS proteins, they found, protect the proteins within pharmaceuticals about 10 times more efficiently than current methods.</p>
            <figure class="richtext-image full-width"><img alt="150323-F-IT851-011.JPG" class="richtext-image full-width" height="521" width="800"
            src="/wgbh/nova/media/images/150323-F-IT851-011.width-800.jpg"/><figcaption><p>Vaccines and other protein-based pharmaceuticals currently rely on a temperature-controlled supply chain. In developing countries, it can be logistically challenging and immensely expensive to keep vaccines cold, and therefore viable. Image Credit: U.S. Air Force/Senior Airman Areca T. Wilson</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>The team’s ultimate goal, Boothby says, is to use CAHS proteins to protect human blood in blood banks. It&#x27;s a challenge, because our blood is much more complex than the protein-based pharmaceuticals the team is currently working with. Blood is made up of many types of cells, each of which contain different types and ratios of proteins. So, the team will first attempt to use CAHS proteins to preserve each individual kind of cell found in our blood. If they can master this, the researchers hope, they can use CAHS proteins to preserve blood in its complete state.</p><p>“The FDA keeps a tap on refrigerated blood for 60 days,” Boothby explains. “After that, you have to throw it out. You can imagine if there are soldiers on patrol, they can’t carry a mini fridge on their back. But, if we can get whole blood at a dry state at ambient or even hot temperatures and soldiers can carry it and someone needs a transfusion, they can just add water and use it.”</p><p>Tenlen, who is not involved in the new research, believes Boothby’s preliminary work “provides encouraging evidence” that CAHS proteins can be used to stabilize biological substances under challenging conditions. But, she cautions, Boothby and his team will have to be careful that CAHS proteins don&#x27;t introduce side effects when used to preserve vaccines and human blood.</p><p>If the team does succeed in stabilizing vaccines and human cells, the societal impact—all originating from the blimp-like tardigrade—could be enormous.</p><p>“You see these animals do these weird things and produce these materials that no other organism has,” Boothby says. “As I was looking into how tardigrades survive desiccation I started to think about how useful these proteins could be for people… And that’s what we should do, as good citizens of the world: help people.”</p></div>
  

  
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<p>Special proteins that help tardigrades survive extreme conditions might be the key to extending the shelf life of life-saving pharmaceuticals.</p>

After Conquering Space, Water Bears Could Save the Global Vaccine and Blood Supply





  
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 <i>
  Editor’s Note: This article was
 </i>
 <a href="http://app.nationalproduction.wgbh.org/e/es.aspx?s=2531&amp;e=1078363&amp;elqTrackId=87bceb0e8d45455b8e6ff9d7c932edc8&amp;elq=04e21e15c26b4a2081fffebffd0b6c2c&amp;elqaid=5339&amp;elqat=1">
  <i>
   originally published
  </i>
 </a>
 <i>
  in an edition of NOVA’s email newsletter, NOVA Lens, and has now been repurposed for NOVA Next. Sign up for NOVA Lens
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   here
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 </i>
</p>
<p>
 On the evening of Saturday, August 11, lightning struck nine miles north of West Glacier, Montana and hit Glacier National Park’s Howe Ridge. A fire began.
</p>
<p>
 By the following day, the Howe Ridge Fire began to expand rapidly, with windy and dry conditions acting as the perfect fuel.
</p>
<p>
 As the fire grew, officials closed surrounding roads and issued an evacuation order for nearby campgrounds as well as Lake McDonald Lodge and North Lake McDonald Road, due east of the fire’s point of origin,
 <a href="https://www.nps.gov/glac/planyourvisit/maps.htm">
  reports the National Park Service
 </a>
 . Management crews plan to establish point protection around structures and evaluate the areas in which they can construct control lines, but they face a major concern: Uneven terrain and the risk of falling trees prevent crews from safely establishing a direct fire line, the Park Service reports. About 250 personnel are assigned to the four fires burning within Glacier National Park, according to its Howe Ridge Fire hotline. Crew members assigned to Howe Ridge are using fire engines or taking to the sky in CL-215 ‘Superscooper’ airplanes and a K-Max helicopter to control the inferno, which currently spans about 3,500 acres.
</p>
<p>
 The Howe Ridge Fire’s estimated containment date, reads its
 <a href="https://inciweb.nwcg.gov/incident/6135/">
  InciWeb
 </a>
 (Incident Information System) page, is approximately 12:00 a.m. on Thursday, November 1. But unfortunately, the embers could affect the landscape even after its last plume of smoke is distinguished, Jason Kean a U.S. Geological Survey research hydrologist who works with USGS’ Landslide Hazards Program, warns. Usually attributed to interactions between heavy rains, loose bedrock and gravity, landslides can be an all-too-real consequence of forest fires.
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      <div class="rich-text"><p>
 “You can look on Google Earth and see these scars from shallow landscapes all around,” he says.
</p>
<p>
 Fire primes a landscape for a slide in a few ways. When a fire strikes, some trees––sometimes many––are felled. The vegetation is like a “blanket on the soil,” Kean explains, with trees functioning as an anchor, securing soils in place. “When you remove the vegetation, raindrops can directly hit the soil and make those particles move.”
</p>
<p>
 But fire also chars the earth, transforming the hydrology, or water content, of its soil. As the soil burns, precipitation is less able to penetrate below the soil’s surface level. The ground’s surface could become unstable, and instability is a key ingredient for a landslide. Thanks to gravity, soil on a slope is most at risk.
</p>
<p>
 Most of Glacier National Park’s precipitation falls as snow, the National Park Service’s National Parks Fire Programs Coordinator Richard Schwab explains, but the Park is also home to powerful thunderstorms––the very cause of the Howe Ridge Fire. “It’s the summer thunderstorms that can trigger the kind of event that we’re concerned about,” Schwab says.
</p>
<p>
 “Particularly right after the fire, when the earth doesn’t have that blanket of vegetation, an intense storm can cause a real problem,” Kean adds. “Then in the spring, if you were to get rain on top of snow, the rain could melt the snow and essentially cause double the amount of water.”
</p>
<p>
 In the first year or two after the fire, the roots of trees it destroyed will still be intact, effectively creating support for the soil. But in time, the tree roots start to decay, and a shallow landslide–– one where the surface layers of soil slough off––can occur. Surface landslides can occur up to 10 years after a fire, Kean warns.
</p>
<p>
 Already, the Howe Ridge Fire has destroyed numerous private summer residences, park-owned boathouses, a camp house and its outbuildings. Tourists are being encouraged to stay on Glacier’s east side. Throughout Tuesday night, fire management crews heard noises that resembled gunfire, Montana’s
 <a href="https://www.greatfallstribune.com/story/news/2018/08/15/falling-trees-sound-like-gunshots-glacier-park-fire/999214002/">
  <i>
   Great Falls Tribune
  </i>
 </a>
 reports––sounds made by trees collapsing to the ground.
</p>
<p>
 When rain finally falls again upon Howe Ridge, having fewer trees could cause its terrain to more readily slurp up moisture.
</p>
<p>
 Working with the
 <a href="https://www.nps.gov/glac/planyourvisit/maps.htm">
  NPS’ Burned Area Emergency Response
 </a>
 and other fire response teams, the USGS will conduct a debris-flow hazard assessment for the region scorched by the Howe Ridge Fire. This assessment entails using satellite imagery to generate a map of the burned area, finding the slope of the terrain within that area, and applying rainstorm models that are low, moderate, and severe in intensity to gauge the range of potential for a landslide, among “a whole suite” of other conditions, Schwab says, including at-risk “critical cultural resources, erosion, natural resources, invasive species and endangered species.”
</p>
<p>
 The Howe Ridge assessment will have to wait until its fire gets close to containment, USGS researchers say, but last year, the
 <a href="https://landslides.usgs.gov/hazards/postfire_debrisflow/detail.php?objectid=147">
  Sprague Fire
 </a>
 , which burned on the other side of Lake McDonald from the Howe Ridge Fire, was one of 96 different fires across the country that the USGS conducted an assessment for in 2017.
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 “Fortunately, that fire didn’t become problematic, unlike the others I’ve worked on,” Schwab, who’s currently stationed at California’s nearly 200,000-acre Carr Fire, says of the Sprague. He cautiously adds: “The Sprague fire has the potential to create a problem if you get the right rain event.”
</p>
<p>
 Responsible for the deaths of
 <a href="https://www.nbcnews.com/news/us-news/body-mother-found-after-california-mudslide-death-toll-rises-21-n839546">
  21 people
 </a>
 , California’s 2017 Thomas Fire caused some of the worst debris flows that Kean had ever seen. “People need to plan for these events as soon as possible,” he says.
</p>
<p>
 The intensity of the Thomas Fire’s landslides makes Kean worry about the repercussions of California’s Mendocino Complex Fire––the state’s largest in recorded history––most. But he stresses that landslides are a very real repercussion within Montana’s Glacier National Park, too.
</p>
<p>
 “It’s definitely a possibility,” he says of landslides occurring as a result of the Howe Ridge Fire. “In 2003 and 2006, there were a bunch of debris flows that were associated with fires that aren’t too far from Howe Ridge. When you have intense slopes like these, there’s always the possibility."
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 Photo credit: NPS Photo
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<p>Embers from the Howe Ridge Fire could affect the landscape even after its last plume of smoke is distinguished.</p>

A Fuming Glacier National Park Faces Long-Term Consequences





  
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      <div class="rich-text"><p>
 <i>
  Editor’s Note: This article was
 </i>
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  <i>
   originally published
  </i>
 </a>
 <i>
  in an edition of NOVA’s email newsletter, NOVA Lens, and has now been repurposed for NOVA Next. Sign up for NOVA Lens
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<p>
 During his time in the trenches of World War I, Dr. Lawrence Bruce Robertson, a Canadian surgeon who pioneered methods for blood transfusion, watched three men die of ruptured blood cells, multi-organ damage, and eventual organ failure—symptoms of a condition called paroxysmal nocturnal hemoglobinuria (PNH).
</p>
<p>
 It was a time before scientists had identified the four major blood types in humans: A, B, AB, and O. The men Robertson had seen die had passed away due to a violent reaction to the blood they were given, which was incompatible with their own blood type.
</p>
<p>
 We now know that type O blood, which is a recessive trait, is the “universal donor.” If a blood transfusion is necessary, those with type O blood must receive type O blood; on the contrary, type O can be safely administered to all blood types. Now, in
 <a href="https://www.acs.org/content/acs/en/pressroom/newsreleases/2018/august/gut-bacteria-provide-key-to-making-universal-blood-video.html?_ga=2.73840727.473629983.1535079314-891657040.1535079314">
  a new study
 </a>
 , researchers report that they used newly discovered gut bacteria enzymes to convert type A blood to type O at a rate faster than ever before. Omnipresent blood shortages could soon be no more.
</p>
<p>
 “What we’d be able to do, if this passes all the safety regulations, is to expand that reserve of available blood,” said Dr. Steve Withers, a professor of biochemistry at the University of British Columbia and the senior author of the new study, which he presented at the
 <a href="https://global.acs.org/events/256th-acs-national-meeting-exposition/">
  American Chemical Society National Meeting
 </a>
 in Boston on Tuesday.
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 First developed by the late Jack Goldstein of the New York Blood Center, the idea of
 <a href="https://www.nysun.com/national/scientists-convert-blood-to-type-that-can-be/51631/">
  converting type A, B, or AB blood to O
 </a>
 has been around for a while, explains Chief Scientist of the Canadian Blood Services Dr. Dana Devine, who was not involved in the new study. The challenge, she adds, has been how to commercialize it.
</p>
<p>
 “He’s got an enzyme that’s way more active and you can use less of it,” Devine said of Withers. “He may have the breakthrough to get over the cost hurdle,” she adds, referring to older methods with price tags that prevented them from becoming marketable.
</p>
<p>
 Some enzymes from bacteria that can be cultured in a lab––of which there are about 10,000, Withers points out––can be used to cut off the antigens, or small sugar or protein molecules, from type A or type B blood, effectively turning it to type O. (If an enzyme that feeds on type A antigens is paired with one that feeds on type B antigens, type AB blood can be converted to O.) In
 <a href="https://pubs.acs.org/doi/10.1021/ja5116088">
  a 2015 study
 </a>
 , published in the
 <i>
  Journal of the American Chemical Society
 </i>
 , Withers and his team found an enzyme that was capable of very slowly munching on type A antigens. Manipulating evolution, the researchers tweaked the enzyme, improving its ability to remove the sugar molecules by 170-fold.
</p>
<p>
 But Withers, an enzymologist with 35 years of experience, suspected that nature––specifically the human gut––had an even greater solution.
</p>
<p>
 “The human gut contains the A and B antigens,” he said. “It would make sense that bacteria would evolve to clip them off.”
</p>
<p>
 To see if this was the case, Withers and his team partnered with Dr. Jayachandran Kizhakkedathu, a pathologist at the Centre of Blood Research, and Withers’ University of British Columbia colleague Dr. Steven Hallam, a microbiologist and immunologist whose lab specializes in metagenomics, the study of genetic materials recovered directly from nature as opposed to those produced in a lab.
</p>
<p>
 Microbes are shaping the Earth’s environment and its other organisms, Hallam said, and there are far more of them than neurons and stars in the universe. “People are becoming more interested in tapping into that massive diversity of life, which creates an opportunity to discover enzymes and catalysts to solve worldwide problems,” he explains.
</p>
<p>
 With the support of Hallam’s lab, Withers’ team sifted through human feces to extract their bacterial DNA, then chopped the DNA into very large chunks, which on average contain 20 to 30 genes. They inserted those genes into an infamous host that’s easily cultivated in the lab—
 <i>
  E. coli
 </i>
 . “And then,” Withers said with a small chuckle, “we basically crossed our fingers and hoped these genes could be encoded.”
</p>
<p>
 It worked. The gut enzymes were even more efficient than those the team developed three years ago.
</p>
<p>
 The potential significance for society is profound, Devine said. “It would allow blood systems to do a much better job of managing their industry. They’re always struggling to get enough O blood––O donors––in the door,” she said of blood drives.
</p>
<p>
 In the event of an emergency transfusion, doctors automatically administer type O blood to a patient; taking time to conduct a screening could be life-threatening. Appeals for type O donors are therefore high, particularly in the summer months. “People start going on vacation and the general blood supply starts to drop,” Devine says. “Sometimes, you get increases in demand with people traveling. More traffic causes more accidents. It all lines up in the wrong way.”
</p>
<p>
 The new research is still in its preliminary stages. Through collaborating with the CDC and Canadian Blood Services, the team will have to perform further in vitro testing to determine whether blood converted from type A to O using gut microbe enzymes––which researchers would remove from the blood before administering it–– could cause abnormal reactions in patients. But if it passes safety studies, including a Phase 3 clinical trial in, the societal significance would be tremendous.
</p>
<p>
 “As scientists, we don’t often get the opportunity to make discoveries that make such a large human impact in the world. It’s rare. It’s a glorious thing. The idea of being able to take any kind of blood and transform it into any form would have a major health impact. It would literally save lives. And turning to the human body to find that solution is very elegant,” Hallam says. “It’s just beginning.”
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 Photo credit: @tOrange.biz 2004-2018 / (CC-BY 4.0)
</p></div>
  



<p>In a new study, researchers report that they used newly discovered gut bacteria enzymes to convert type A blood to type O at a rate faster than ever before. Omnipresent blood shortages could soon be no more.</p>

Scientists Find Enzyme That Could Help Create Universal Blood Type





  
      <div class="rich-text"><p>NASA’s <a href="https://www.nasa.gov/mission_pages/newhorizons/main/index.html">New Horizons</a> spacecraft confirmed a successful flyby of the enigmatic Kuiper Belt object Ultima Thule, just a few days shy of the thirteenth anniversary of the space probe’s initial launch in 2006, yesterday.</p><p>NOVA is reporting live from the Johns Hopkins Applied Physics Laboratory in Laurel, MD.</p><p>NASA&#x27;s New Horizons team just released the first images captured by the New Horizons spacecraft during the Ultima Thule flyby.</p>
            <figure class="richtext-image full-width"><img alt="Ultima Thule Revealed1" class="richtext-image full-width" height="585" width="533"
            src="/wgbh/nova/media/images/20190102-pr.width-800.png"/><figcaption><p>“What you’re seeing is the first contact binary ever explored by spacecraft,&quot; New Horizons Principal Investigator Alan Stern said shortly after revealing the most up-to-date photo of Ultima Thule released by the NASA New Horizons team. Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p> “Just about 36 hours ago, New Horizons swept down on Ultima Thule in an event that’s never been attempted before when it comes to space flight,&quot; <a href="https://twitter.com/NASANewHorizons">NASA New Horizons&#x27;</a> Principal Investigator Alan Stern said. &quot;We didn’t even know of this object until 2014. It’s only about as large as Washington D.C., and about as dull as garden dirt,&quot; Stern added of Ultima Thule with a laugh. He explained that before the flyby event, New Horizons had to plunge toward Ultima at a speed of 32,000 miles an hour.</p><p>&quot;I don’t think we stressed this enough,&quot; he said. &quot;What this team and this spacecraft did is unprecedented.&quot;</p><p>Carly Howett, a planetary scientist on the New Horizons team, explained that &quot;now, we can definitively say that Ultima is red.&quot; &quot;Both lobes—both Ultima and Thule—are red,&quot; she said. &quot;But the neck section is brighter.&quot;</p>
            <figure class="richtext-image full-width"><img alt="Ultima is Red" class="richtext-image full-width" height="593" width="800"
            src="/wgbh/nova/media/images/Dv7djHBU8AE1BUS.width-800.jpg"/><figcaption><p>Using a composite of pictures, the NASA New Horizons team was able to discern the color of Ultima Thule—a rusty red.</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>On the morning of January 1, at approximately 10:31 a.m. EST, the New Horizons team received their first information from the spacecraft&#x27;s historic flyby.</p><p>&quot;Ultima Thule is finally revealing its secrets to us. And even though it’s still a pixelated blob,&quot; Hal Weaver, New Horizons project scientist, said, &quot;it’s a better pixelated blob.&quot;</p><p>Shape-wise, the team explained at the time, the now iconic Kuiper Belt object could be one of two things: a double-lobed peanut-like object, or two objects orbiting each other.</p>
            <figure class="richtext-image full-width"><img alt="IMG_0545.jpg" class="richtext-image full-width" height="533" width="800"
            src="/wgbh/nova/media/images/02newhorizons4-jumbo.width-800.jpg"/><figcaption><p>An image of Ultima Thule, taken before the flyby and unveiled on New Year&#x27;s Day. Ultima Thule may be a single, peanut-shaped object, or two objects stuck together; it&#x27;s also still possible that there are two closely associated objects orbiting each other. New Horizons is thought to be approaching it from the side, as if descending down onto the top of a rotating propeller. Image Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>“We have a healthy spacecraft,&quot; Alice Bowman, the New Horizons Mission Operations Manager, AKA &quot;MOM,&quot; said. &quot;We just completed the farthest flyby.”</p>
            <figure class="richtext-image full-width"><img alt="Alan Stern hugs Alice Bowman" class="richtext-image full-width" height="450" width="800"
            src="/wgbh/nova/media/images/Sequence_06.00_01_59_06.Still002.width-800.jpg"/><figcaption><p>Alan Stern, the New Horizons mission principal investigator, hugs Alice Bowman, mission operations manager, after receiving news of a successful flyby.</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>Hal Weaver, New Horizons project scientist, cheered from the front row as Bowman&#x27;s team announced that the spacecraft was healthy and had power.</p>
            <figure class="richtext-image full-width"><img alt="Hal Weaver Cheers" class="richtext-image full-width" height="500" width="750"
            src="/wgbh/nova/media/images/Unknown_18DsWgu.width-800.jpg"/><figcaption><p>Hal Weaver, the New Horizons Mission project scientist, cheers from the Johns Hopkins Applied Physics Laboratory auditorium after receiving news of the successful Ultima Thule flyby.</p><div class="credit"><p></p></div></figcaption>
            </figure>
            <p>Here&#x27;s what New Horizons team members had to say the days leading up to the historic flyby:</p><p>&quot;Things have been happening so fast. I think all of us have been working through the weekend, so don&#x27;t ask us what day it is,&quot; Bowman said.</p><p>&quot;This definitely is more stressful than Pluto. Pluto is a much larger object. We&#x27;ve known about Pluto since 1930. This object we only discovered in 2014,&quot; she adds of Ultima Thule, an object in the Kuiper Belt that is approximately 20 miles wide and 4 billion miles away, which <a href="https://www.pbs.org/wgbh/nova/article/new-horizons-ultima-thule-preview/">New Horizons will attempt to fly by</a> at 12:33 a.m. on New Year&#x27;s Day (January 1). &quot;This is a type of object that no spacecraft has ever observed up close. It&#x27;s in an orbit that the scientists say has not been disturbed by anything since the formation of the solar system, so it&#x27;s really, really neat to see what this object looks like and how it compares to the other objects that we see in our solar system.&quot;</p></div>
  

  
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      <div class="rich-text"><p>&quot;[Yesterday] morning we actually made a slight adjustment to the observations onboard the spacecraft—we call that a knowledge update—and we found that we were arriving a little bit late. So we needed to adjust a few seconds so that we would arrive at that optimum point. The subject is so small. It&#x27;s possible that the observations that target the surface of Ultima could, worst case, be just black sky,&quot; Bowman said.</p>
            <figure class="richtext-image full-width"><img alt="BPL_111_Alice_Multigroup.jpg" class="richtext-image full-width" height="450" width="800"
            src="/wgbh/nova/media/images/BPL_111_Alice_Multigroup.width-800.jpg"/><figcaption><p>Alice Bowman tells NOVA about the New Horizons mission.</p><div class="credit"><p></p></div></figcaption>
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            <p>&quot;We all feel this connection to the spacecraft even though it&#x27;s four billion miles from Earth. We feel that connection and we&#x27;re proud of what it has accomplished and what it will accomplish.&quot;</p></div>
  

  
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      <div class="rich-text"><p>“We could see Pluto begin to show itself months ahead of time. And days and weeks ahead, we had a very good idea of what Pluto looked like,&quot; Encounter Mission Manager Mark Holdridge, who has been working on the New Horizon&#x27;s mission for 17 years, said. &quot;Ultima—it&#x27;s not showing us anything. We won&#x27;t be able to tell anything about shape until after the flyby when we get some of the first pictures back. We&#x27;ll begin to see sort of its secrets revealed...That&#x27;s the hope anyhow. But you never really know.&quot;</p>
            <figure class="richtext-image full-width"><img alt="Mark Holdridge" class="richtext-image full-width" height="450" width="800"
            src="/wgbh/nova/media/images/MARK_H.width-800.jpg"/><figcaption><p>Mark Holdridge tells NOVA about the New Horizons mission.  </p><div class="credit"><p></p></div></figcaption>
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            <p>&quot;You spend years preparing for something like this and before you know it it&#x27;s over. And sometimes you forget—you get caught up in the moment. You really do have to slow down once and say, &#x27;This is really it. Let&#x27;s make the most of this.&#x27;&quot;</p><p></p><p>&quot;<a href="https://www.pbs.org/wgbh/nova/video/pluto-and-beyond/">Pluto and Beyond</a>&quot; premieres Wednesday, January. 2 at 9/8c on PBS.</p><p></p></div>
  

  
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<p>NASA&#x27;s New Horizons spacecraft is about to fly by Ultima Thule, an object in the Kuiper Belt. NOVA reports live from the Johns Hopkins Applied Physics Laboratory in Laurel, MD.</p>

Sukee Bennett

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