Doesn't current medical evidence show long-term use of neuroleptic psychiatric drugs can cause structural brain changes and cognitive problems? So wasn't Nash right -- that neuroleptics could have ruined his beautiful mind? And shouldn't neuroleptic users be warned?
Answered by Raquel E. Gur, M.D., Ph.D.:
Anatomic changes and cognitive difficulties have been documented in individuals with schizophrenia who have never been exposed to treatment with anti-psychotic medications. Therefore we can not conclude that treatment causes the brain changes and the cognitive deficits. Few studies have examined people longitudinally and the findings at this point are not conclusive.