- U.S. Buys Louisiana Territory - 1803
- Lewis and Clark Explore the Northwest - 1804
- War of 1812 - 1812-1815
- American Factory System - 1813
- Purchase of Florida - 1819
- Missouri Compromise - 1820
- Monroe Doctrine - 1823
- Erie Canal Opens - 1825
- Trails of Tears - 1830
- First Telegraph Message Sent - 1843
- The Great Westward Migration - 1843
- Annexation of Texas - 1845
- Mechanical Reaper Comes to the Midwest - 1847
- Treaty of Guadalupe Hidalgo - 1848
- The Gold Rush - 1848
- Border with Mexico Established - 1853
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