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The Red Queen
is a metaphor for
evolutionary
change. |
Enter
the Red Queen |
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In the late
1980s the Red Queen hypothesis emerged, and it has been
steadily gaining popularity. First coined by Leigh Van Valen of the
University of Chicago, it refers to Lewis
Carroll's Through the Looking Glass, in which the
Red Queen tells Alice, "[I]t takes all the running
you can do, to keep in the same place." This never-ending
evolutionary cycle describes many natural interactions
between hosts and disease, or between predators and prey:
As species that live at each other's expense coevolve,
they are engaged in a constant evolutionary struggle for
a survival advantage. They need "all the running they
can do" because the landscape around them is constantly
changing. |
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The Red Queen hypothesis for sex is simple: Sex
is needed to fight disease. Diseases specialize
in breaking into cells, either to eat them, as fungi
and bacteria do, or, like viruses, to subvert their
genetic machinery for the purpose of making new viruses.
To do that they use protein molecules that bind to other
molecules on cell surfaces. The arms races between parasites
and their hosts are all about these binding proteins.
Parasites invent new keys; hosts change the locks.
For if one lock is common in one generation, the key
that fits it will spread like wildfire. So you can be
sure that it is the very lock not to have a few generations
later. According to the Red Queen hypothesis, sexual
reproduction persists because it enables host species
to evolve new genetic defenses against parasites that
attempt to live off them.
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Immune cells
have receptors
("locks") for
binding proteins
("keys") of viruses
such as HIV, that
allow them to
dock and
gain entry. |
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