Three years before the Gold Rush, 87 pioneers took a shortcut westward to California, only to get caught in the snows of the Sierra Nevada.
When two passenger ships collide off Nantucket in 1909, 1,500 people rely on 26-year-old Jack Binns to operate a new technology - wireless telegraphy - to save them all.
The international race to develop biological weapons during the 20th century.
It was the largest fire in American history: by the time it was all over, more than three million acres had burned and at least 78 firefighters were dead.
In the early 1830s, Texas, ruled by Mexico, held 20,000 U.S. settlers and 4,000 Mexican Tejanos, forcing residents to pick sides.
A year in the life of Wyoming cowboys and the ranching families of the American West.
The impact of tuberculosis in America, once the deadliest killer in human history.
In 1960, Francis Gary Powers' U-2 spy plane was shot down over the Soviet Union.