On Wednesday’s NewsHour…

OBAMA, KARZAI REAFFIRM TIES | President Obama met with Afghan President Hamid Karzai in Washington, following months of tension over accusations of governmental corruption and Western interference.Gwen Ifill talks to former Ambassador Zalmay Khalilzad and Alexander Their, director for Afghanistan and Pakistan at the United States Institute of Peace about the state of U.S.-Afghan relations.

OIL LEAK PROBE UPDATE | Tom Bearden continues his reporting from the Gulf of Mexico with an update on hearings into the massive oil spill, as investigators testified that the Deepwater Horizons oil well failed a key pressure test just hours before the explosion.

SHANGHAI WORLD EXPO | As China kicks off its five-month World Expo festivities in Shanghai, Jeffrey Brown talks to Ray Suarez about what is on displayed in the international pavilions at the largest, most expensive World’s Fair in history.

MISSISSIPPI FIGHTS CHILDHOOD OBESITY | As First Lady Michelle Obama implements a national plan to end the U.S.’s childhood obesity epidemic, Betty Ann Bowser looks at the battle being waged in Mississippi against the fried dishes that have become traditional staples in the state.

ASTRONAUTS WEIGH IN ON SPACE PROGRAM CUTS | Astronaut Neil Armstrong made a rare public appearance to testify before Congress about the future space exploration. Kwame Holman reports on the divisions about the future of space exploration and plans to scrap NASA’s Constellation program.

AUTHOR WES MOORE EXAMINES A DIFFERENT DESTINY | Judy Woodruff talks to Baltimore native Wes Moore about his new book, ‘The Other Wes Moore’ which explores the stories of two inner-city young men who share the same name, but lead very different lives.

Monday’s anchors are Judy Woodruff and Gwen Ifill. Hari Sreenivasan will have the day’s other top news stories and a look at Web features, including more on the childhood obesity debate from a teen struggling to meet military weight requirements, Ray Suarez’s latest dispatch from China and a slide show of photos by Chinese children affected by the earthquake two years ago, and an examination of the British government’s official power-sharing agreement.

And, on NewsHour Plus, David Epstein of Sports Illustrated describes the latest research on genetics and athletic ability.

We hope you join us.