On Wednesday’s NewsHour…

AFGHAN STRATEGY AFTER MCCHRYSTAL | The U.S. mission in Afghanistan will be in new hands, following the resignation of Gen. Stanley McChrystal over disparaging remarks about the Obama administration. Gwen Ifill talks with Jessica Matthews, of the Carnegie Endowment for International Peace; Elliot Cohen, a professor at the Johns Hopkins School of Advanced International Studies; and David Ignatius, a Washington Post columnist about the decision and its consequences for the U.S. strategy in Afghanistan. Then, Ray Suarez talks to Michael Desch, a political science professor at the University of Notre Dame, and Brett McGurk, a former presidential national security adviser, about what the decision could mean politically for the president.

HEALTH AND THE GULF OIL DISASTER | As the oil cleanup along the Gulf Coast continues, Betty Ann Bowser reports on the health worries that are arising for coastal residents.

SOUTH CAROLINA POLITICS | Four states held primaries and runoffs on Tuesday, with outcomes that could foreshadow an anti-incumbent backlash by voters in November’s general election. Judy Woodruff talks to Hotline’s Amy Walter and Adolphus Belk, Jr., a professor of political science and African-American studies at Winthrop University, about what those wins mean for the general election.

NASHVILLE FLOOD RECOVERY | Six weeks after record floods devastated Nashville, the city is making a comeback. Jeffrey Brown examines the rebuilding efforts of its citizens and its vibrant music industry.

Wednesday’s anchors are Judy Woodruff and Gwen Ifill. Hari Sreenivasan will have the day’s other top news stories and a look at Web features, including all of President Obama’s announcement on Gen. McChrystal’s replacement and a Q & A about past divisions between military and civilian officials.

Plus, NPR’s Mike Pesca describes the mood in the World Cup stadium following the U.S. team’s stunning last minute victory and an Art Beat profile of bluegrass musician Dave Rawlings, the longtime music partner of Gillian Welch.

We hope you join us.