The Pakistani government declared a national holiday to honor the Prophet Muhammad and encourage peaceful protest. But violence quickly escalated, the brunt fueled by anti-American sentiment over continued U.S. drone strikes and an anti-Islam film that defamed the Muslim prophet.

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Al-Qaida claimed responsibility on Thursday for last month's attack on a base in Khost, Afghanistan, that killed seven CIA agents. According to Islamist Web sites, the attack was "revenge" for U.S. drone strikes in Pakistan.

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