CRISPR

Chinese scientist linked to gene-edited babies sentenced to prison

By Ken Moritsugu, Associated Press

Normal red blood cells and a sickle cell RBC (top) found in a blood specimen of an 18-year-old female patient with sickle cell anemia. Photo by Janice Haney Carr / Sickle Cell Foundation of Georgia

First CRISPR treatment for sickle cell, other blood disease shows early benefits in two patients

The first two patients to receive a CRISPR-based treatment for the inherited blood disorders sickle cell disease and beta thalassemia have benefited from the experimental therapy and experienced only temporary and treatable side effects.

By Sharon Begley, Adam Feuerstein, STAT

Doctors use CRISPR gene editing against cancer for the 1st time in the U.S.

Doctors were able to take immune system cells from the patients' blood and alter them genetically to help them recognize and fight cancer, with minimal and manageable side effects.

By Marilynn Marchione, AP Chief Medical Writer

For the millions of people infected with HIV, the best way to manage the disease is antiretroviral therapy, which can lower the amount of HIV replicating in the body to undetectable levels. But antiretroviral therapy (ART) can only manage HIV, never eliminate it. A new study of mice charts a preliminary path to eliminating this medication dependency, through gene editing with CRISPR. Photo by DigitalGenetics/via Adobe

CRISPR gene-editing ‘eliminates’ HIV in some mice. What does it mean for humans?

Antiretroviral therapy is the standard HIV treatment, but patients are never rid of the virus. A new study raises the possibility of HIV elimination through gene-editing with CRISPR.

By Berly McCoy

‘Jumping genes’ could help CRISPR replace disease-causing DNA, study finds

Researchers describe combining a "jumping gene" with CRISPR enzymes to deliver a a package of DNA to precise addresses in the E. coli genome.

By Sharon Begley, STAT

How a snail’s shell gets its twist

By Vicky Stein

Gene-editing with CRISPR reveals why snail shells are asymmetrical and coil either left or right.

NIH director says there’s work to do on regulating genome editing globally

By Lev Facher, STAT

The apparent birth this month of the first genetically modified babies is “a lesson in the potential for human hubris to overtake us,” Dr. Francis Collins, the director of the National Institutes of Health.

CRISPR causes significantly greater DNA damage than previously thought, study finds

By Sharon Begley, STAT

The DNA damage found in the new study included deletions of thousands of DNA bases, including at spots far from the edit. Some of the deletions can silence genes that should be active and activate genes that should be silent,…