WATCH: White House COVID-19 task force holds briefing after Biden unveils action plan

President Joe Biden’s sweeping new federal vaccine requirements is certain to face a barrage of legal challenges alleging government overreach.

Watch the briefing stream in the video player above.

On Thursday, Biden unveiled new mandates to get 100 million Americans vaccinated and ensure children can return to school safely. In his speech, Biden expressed frustration with people who have have not yet gotten vaccinated.

“We’ve been patient. But our patience is wearing thin, and your refusal has cost all of us,” he said. The unvaccinated minority “can cause a lot of damage, and they are.”

But the administration appears to be on firm legal ground to issue the directive that will affect as many as 100 million Americans in the name of protecting employee safety.

The administration is gearing up for another major clash between federal and state rule.

READ MORE: 4 takeaways about Americans’ COVID views at summer’s end

The proposed rules will be drafted in the coming weeks by the Occupational Safety and Health Administration, which will impose fines of up to $13,600 per violation if a workplace does not comply.

Republicans swiftly denounced the mandate as government overreach and threatened legal action.

Even if the mandates are tossed out, millions of Americans will get a shot because of the new requirements — saving lives and preventing the spread of the virus.

Biden is putting enforcement in the hands of the Occupational Safety and Health Administration, which is drafting a rule “over the coming weeks,” said Jeffrey Zients, the White House coronavirus response coordinator.

“If a workplace refuses to follow the standard, the OSHA fines could be quite significant,” Zients said.

The expansive rules mandate that all employers with more than 100 workers require them to be vaccinated or test for the virus weekly, affecting about 80 million Americans.

And the roughly 17 million workers at health facilities that receive federal Medicare or Medicaid also will have to be fully vaccinated.

Employees of the executive branch and contractors who do business with the federal government will also have to be vaccinated — with no option to test out. That covers several million more workers.

So far, nearly three-quarters of Americans age 12 and older have received at least one vaccine dose, according to the latest data from the Centers for Disease Control and Prevention. But millions of Americans remain vulnerable to the virus. And no vaccine has been authorized for children aged 11 or younger.

In the latest PBS NewsHour/NPR/Marist poll, 19 percent of U.S. adults said they had no plans of getting vaccinated. That resistance hss diminished since earlier in the summer, when 28 percent said they would not get inoculated against COVID-19.

That reluctance has contributed to the latest surge in new cases, hospitalizations and deaths, which has overwhelmed health care systems, especially in parts of the country with low vaccination rates.

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