>> Ted: Coming up on Arizona PBS, on Arizona horizon, a closer look at former President Trump's Florida residence and later in the hour on break it down, a look at how one culture sways much of today's modern music.

That's ahead in the next hour on Arizona PBS.

The FBI's search of former President Trumps' home in Florida sent shockwave's of politics.

It was one of the most significant actions ever taken by both the FBI and justice department.

Of what it might suggest, we welcome the former partner and Roy, I'm looking forward to this and I have a lot of questions as do a lot of folks and too early for a lot of answers, but we can figure out what direction things are going?

How surprising was this FBI action?

>> It's an unprecedented situation.

We haven't had a search warrant executed on a former president and it's surprising to see.

That being said, we've had hints from the information from the January 6th committee.

Also, though, the department of justice has been looking into the issue.

The issue being, did the former president take classified, national security information from the White House to Mar-a-Lago, which is a violation of federal law?

I'm not surprised we've escalated and we've never seen this historically, and some will be speculation on why the FBI and department of justice escalated it to this level.

>> Ted: It would seem to suggest a high bar for probable cause.

Is that what you're thinking?

>> With the search warrant, there had to be probable cause a crime had been committed and a federal judge, a magistrate judge in law Florida would have to sign off on the search warrant.

But before that point, before the search warrant is presented to the federal judge, internally at the FBI and the department of justice, there had to be a lot of approval and because of the sensitive nature both from political perspective, this got to be top at the department of justice and FBI, officials and both agencies would have to approve this before it was presented to the judge.

This is speculation, it wouldn't surprise me the FBI director and director were involved before it went forward.

>> Ted: A judge has to say what, a crime was committed?

>> A probable cause a crime occurred and given how sensitive, a lot of people looking at this before the judge looked at it and the judge would have to put his name on the line to have this executed.

What's interesting to me, thinking about how we got here, the national archives found out confidential information, national security information had been moved over to Mar-a-Lago and there was a grand jury and the department of justice got involved and subpoenas issued and according to to news reports, some cooperation from the former president and then we see this with the search warrant executed and that tells me that either the documents are produced before, indicating to the department there was a crime that what's committed and we have probable cause or this could be a situation where, perhaps, the former president stopped cooperating with the grand jury and everything had to be escalated.

>> Ted: Could it be a point where mishandling of misinformation, that's one thing and isn't the real focus if that information, that classified information is passed onto a third party, isn't that where the rubber meets the road?

>> That's right.

And I think right now what they're looking at and seeing this that there's 15 boxes of documents at mar Mar-a-Lago that these seized and we've heard in the past, they want to do interviews with people at Mar-a-Lago and other trump officials to see who received this information and who had information to this classified information.

So I think that's the kind of thing the investigator is looking at to see whether there was a crime committed.

>> Ted: The former president made a point of emphasis, they broke open a safe and is that unusual in these kinds of things?

>> Not that a search warrant will provide the authority to do those kind of intrusive searches.

To me, it's interesting because most of the time, if have a safe, there's something in that safe you don't want people to have easy access to.

In this case, because of the search warrant, they broke into it, according to the former president and seized documents.

I would be curious to see what documents he put in the safe.

The other thing I would add, the former president has said a lot on social media about the execution of the search warrant.

He has a copy of the search warrant and he could show the public what search warrant was executed on him and what kind of documents they were looking to get.

>> Ted: I was going to ask that very question.

Given a search warrant, that does not have to be confidential, does it?

I can show it to anyone if I so choose.

>> That's right.

Any time a search warrant is executed, it is left behind, and nothing to prevent him, because he was the subject, to show the public exactly what was executed upon him.

Of course, he's been saying on social media, the name of the search and why it's inappropriate.

He could theoretically show everybody and make the argument there.

But thus far, not shown it to the public.

>> Ted: From where we are, this action, this bold action, does this suggest the investigation is in the final stages?

>> It suggests the investigation is very serious.

There's a lot of sensitivity in investigating the former president.

The FBI have been reluctant to get involved in situations where they could be seen as too political.

We have speculation the former president Mepron may run for president again and maybe not interested in getting involved in that kind of situation.

So the fact they went to extraordinary lengths tells me that is a very serious thing that they're trying to pursue.

Whether they're at the final stages or not, that's a hard thing to answer and I say that because the January 6th January 6th committee has uncovered certain information and according to news reports, the FBI is following up and the department of justice is following up.

It's hard to know the types of potential avenues they're investigating reporting to the former president at this point.

>> Ted: All said, would you be surprised if charges were not filed?

>> I would be a bit surprised at this point and I say that primarily because I do not think that the department or the FBI would go to these lengths until they believed there was a there there.

It would be surprised if there wasn't something brought.

The counter argument, they may be reluctant to do that, particularly if the former president decides to run again, which may be his motivation again and this is a bit of political speculation and because the department of justice, the FBI have gone this far, it would surprise me if this doesn't conclude in some indictment regarding the former president.

>> Ted: Great information and great to have you, appreciate it.

>> Thank you.

>> Ted: And up next on Arizona horizon, the link between insulin and cancer.

Found an ASU researchers looking between cancer and the body'sability to produce insulin and this is the college of health solutions.

Good to have you.

>> My pleasure.

>> Ted: Cancer cells can suppress insulin and what's going on?

>> We were studying breast cancer models models and breast cancer is the second leading cause of mortality in women.

What we know from the large population studies is that women with breast cancer have a higher risk of type II diabetes than those not diagnosed.

My collaborator, Emily Wong, was interested in figuring out why was this?

We investigated why this was and calm up with a mechanism?

>> Ted: How was the research conducted?

>> Dr. Wong was studying in mice and cells and with my contribution, we took this further into looking into human subjects.

>> Ted: What was found?

>> Was that the cancer cells, the tumor cells themselves are secreting small little vessels that leave the tumor cell and into the bloodstream and circulates throughout the body and goes down into the organ called the pancreas and hits the cells and causes a decrease in insulin secretion and this causes a rise in the blood sugar levels and tumors love that.

They love sugar.

>> Ted: We'll talk about tumors and Glucose and that's fascinating that the cancer cells get down to the pancreas and cause these cancer cells cause mayhem everywhere.

>> Just these little pods called extracellular vessels.

There's a micro RNA called mirror 122 and this interferes with the secretions.

>> Ted: Does it interfere with anything else or wait to do the business until it gets to the pancreas?

>> We think it's doing other things and other tissues, as well, and we know that, specifically, looking at the insulin see secreting tissues.

The pancreas cells can spot this if it in the bloodstream and the glucose can be processed normally.

In this, they cannot produce this and the sugar stays in the bloodstream and causes problems.

>> Ted: Causes problems in terms of type II diabetes and also with these tumors and live off of this.

The way it came together as this process works in the favor of the tumor cell because they're talking to the Beta cells that are interfering with the insulin secretion and driving up fuel production.

>> Ted: The dependency for sugar, that's relatively new, isn't it?

>> EvacueeWe've that for awhile but not talking to other tissues in the body.

This cross-communication is relatively new and the microRNA's meeting that communication is new.

>> Ted: Is there a way to block the microRNA?

>> There is a way and there are several therapeutic companies cropping up and use some therapeutics use anti-mirrors and kind of like a Velcro administered and that's one way that might be able to used for breast cancer patients and most times when breast cancer is diagnosed and the tumor would be removed.

>> Ted: What was the spark that lead to the research on this and, obviously, the idea is something is going on here and we have breast cancer and type II diabetes and was there a spark involved?

>> One of the major sparks was that breast cancer patients get diabetes with those who haven't had breast cancer and why is that?

One of the suspicions is there was something from the tumor itself triggering that risk.

>> You had the suspicion, but were you surprised at the result?

>> I was surprised and my colleague, Dr. Wong, initiated that in the mice and working together in the humans, who has that was exciting, because this could be a diagnosis and sometimes tumors evade, especially in the early statements, could evade detection and there might be blood tests using this microRNA.

>> Ted: You like at bio markers in cancer?

>> I do that in looking at cancer prevention and also in breast cancer survivors and.

Ted >> Ted: It seems like discoveries are going awfully fast.

>> I'm very excited and the college of health solutions and I'm codirector of the cancer prevention and control and we consist of monthly college of health solutions facultiy and facultiy from Edison and other units at ASU interested in cancer control and what I mean by control is, how do we improve health outcomes from survivors and we're doing a variability a variety of different things and we're interested in medical facilities and care providers.

>> Ted: Congratulations on this research and continued success and thank you for joining us.

>> Thank you very much.

♪♪ >> Ted: The author of a Newhart-felt memoir that chronicles her search for meeting, "stepping back from the ledge," truth from renewal we share her story and to talk about her book and thank you so much and congratulations on the book.

It's weird to say congratulations when it's this kind of a topic and getting that out there has to be such an accomplishment.

The subtitle, a daughter's search for truth and renewal.

Talk to us about that search.

>> Thank you first for having me on hear.

on hear.

here.

It's talking about suicide and the stigma of medical mental health and so much is me trying to figure out why my mom killed herself and so, I do feel that it is a big thing to get it out there and hopeful that it helps other people talk about it.

>> Ted: Indeed.

Talk about your mother and how close were you and what happened to her?

>> We were really close and she was really wonderful and I would say she was an incredible grandmother.

I have four kids and my sister has so much fun.

She was a retired nurse and I thought everything was going really well.

She had some things that didn't seem great and we weren't really worried about her.

In April of 2012, my mom drove to the grand canyon from phoenix and went to the ledge and jumped.

I think after that happened, you know, a lot of us talked about things and when we pieced them together, we could see my mom was troubled, but think I think each one of us had one sort of her life.

You don't always talk about everyone else.

You know the piece they told you and you put it together to learn more about her.

>> Ted: As often with these cases, everyone looks around and says, what could I have done or maybe I should have done this or shouldn't have done that and a lot of blame here.

>> I think that's common and hard afterwards.

I think I spent how many years, maybe not and not as much, trying not to blame myself and saying I can't change what happened, but what can I do moving forward and how can I talk about my mom's story and my story, too, to be helpful to other people or listen to other people's stories, as well.

>> Ted: You have a story here, and it's a serious story, as well, and wound up in a subbasement of despair and said my children would be better off without me and seems so normal and obvious.

Wow!

Talk to us about that.

>> It's weird to, you know, obviously, not about-face anymore.

When my mom died, it was a hard time and I felt this guilt that I should have done different things.

When people say, I don't know how people could have done that, I was there and gives me a different purge on perspective on my mom.

It's not about anyone else and you can't think about other people.

You just think, I don't want to be in this pain and live the way I'm living and that's the point my mom got and where I got and I'm lucky that I have had ang had access to mental health therapy and a doctor who prescribed medicine.

I had people who love me.

It was a combination and luck.

I'm still here.

>> Ted: You're still here and able to write about this and how difficult was it to write this book?

>> I mean, it was hard.

Oh, it's like giving Burt to birth to a child.

No, you have drugs when you have a baby.

So it was hard and I think it came out in pieces.

First I started writing about it, which is silly, on social media and Facebook, and photo captions of moments of my mom.

A couple of people were, like, you who put them together.

Writing it was hard and I won't pretend it's easy and during the process, it was difficult to say things or I feel like, I don't look great in the book, but that's life.

And that was sometimes hard to write, things that are truthful and I needed to look at those and other people needed to look at that.

>> Ted: Sounded like other people needed to look at that and there were secrets talked about in a frank way.

How difficult is it when it comes to your mom, that there are things you will never know?

>> I think it's hard, obviously, really hard.

And I will say like95% of the time I'm OK knowing that and that's pretty much true.

People who are alive, you don't know everything about them and it's difficult and so common about people who have lost someone to suicide, that's almost what eats away at you, you don't know and you think you could have helped.

I try hard to put that into, what can I do to be helpful to other people or telling my mom's story help that not happen to someone else.

>> Ted: You write with suicide, only one person getting an ending and the are left with a story abandoned midsentence.

Do you think it got closer to the end with this book?

>> I think wanting that is almost universal, is that you never know your parents.

You think of them as your month mom or dad and you dew think don't think of them as people.

I have people who hadn't lost their parents to suicide but other ways and learning when their parents die.

Maybe it's their career or friends and I don't want to say grateful for but people knew my mom and she became a more robust person pen and then like a mother and grandmother.

>> Ted: The book hasn't been out long and the "New York Times" and other places look upon this favorably.

What kind of reaction are you getting from nonbook reviewers and what are you hearing from people?

>> I mean, people are kind, which is nice, but I am hearing from a lot of people who have lost someone, as well, or people who have had mental health issues or someone in the family and I'm glad that someone is talking about this or this makes it feel OK to talk about or I've had people tell me about a suicide from their family or someone who is close.

These are people I knew pretty well, so I was somewhat surprised.

Not not like people tell you everything, but a lot of people have a lot of loss and you just don't know that.

I think any time you are vulnerable and share your story, people feel comfortable opening up and I'm glad to do a tiny bit of good in that way.

>> Ted: One of the reviewers said this book will save lives and it has to be rewarding to get that story out there and so other people can know what you went through and how what you went through can help others.

Again, congratulations because this is quite an effort and thank you for joining us.

>> Thank you for having me.

>> Ted: And that is it for now.

I'm Ted sign Simons and you have a great evening.