>>> MAJOR FUNDING FOR KPBS HAS BEEN MADE POSSIBLE BY BILL HOWE FOR OVER 40 YEARS.

CALL ONE 800 BILL HOWE OR VISIT BILL HOWE.COM.

AND BY THE CONRAD FOUNDATION AND BY THE FOLLOWING.

AND BY VIEWERS LIKE YOU.

THANK YOU.

>>> MORE THAN 10,000 PALESTINIANS HAVE BEEN KILLED AND THE RETALIATION IS BEING CHALLENGED HERE AT HOME.

THIS MORNING IN DOWNTOWN SAN DIEGO A GROUP OF ALLIES ON BOTH SIDES DEMANDED A CEASE-FIRE.

THEIR MESSAGE WAS LOUD AND CLEAR.

>> YOU CAN SEE IT ON THEIR FACES AND HEAR IT IN THEIR VOICES.

THESE ARE ALLIES OF THE PALESTINIAN PEOPLE.

SIDE BY SIDE WITH THE JEWISH COMMUNITY.

>> WE ARE DESCENDENTS OF PEOPLE THAT HAVE SURVIVED THE GENOCIDE.

WE KNOW THE PRICE OF SILENCE.

DO YOU WANT TO BE REMEMBERED FOR ENABLING GENOCIDE?

THEY WERE SHOUTING IN UNISON.

HOPING TO BE LOUD ENOUGH TO GET THE ATTENTION OF ALEX PADILLA.

LOCATED IN THIS HIGH RISE BUILDING.

WE KNOW THAT HE UNDERSTANDS GENOCIDE.

HE HAS BEEN VOCAL ABOUT THESE ISSUES BEFORE.

HE HAS THE WEBER HE AND THE HEART TO BE A LEADER IN THIS MOMENT.

>> WE WILL NEVER SUPPORT GENOCIDE.

WE DEMAND THE TAXPAYER MONEY GOES TO SUPPORTING OUR COMMUNITIES HERE LOCALLY.

A BILL CALLING FOR AN IMMEDIATE CEASE-FIRE.

>> INNOCENT LIVES HAVE BEEN TAKEN IN THE GAZA STRIP.

CEASE-FIRE NOW.

>> A PHONE CALL AND VOICEMAIL MESSAGE WAS THE CLOSEST THEY COULD GET TO SENATOR PADILLA TODAY.

THEY LEFT INDEX CARDS WITH THEIR DEMAND THAT THE FOOT OF HIS OFFICE DOOR.

A SPOKESPERSON SAID THAT HE WAS FLYING TO WASHINGTON AND WOULD ISSUE A STATEMENT AT A LATER TIME.

FOR NOW, THESE PALESTINIANS AND THEIR SUPPORTERS WANT THE U.S. TO STOP FUNDING THE ISRAELI EFFORT TO RETALIATE AGAINST THOMAS FOR ITS OCTOBER 7 INVASION AND MASSACRE.

>> OUR GROUP WILL NOT JUSTIFY GENOCIDE.

OUR HUMANITY WILL PULL US TOGETHER IN SOLIDARITY EVERY SINGLE TIME.

ON THAT, THEY DO AGREE.

KPBS NEWS.

>> MID-DAY DISH AND DISCUSSED DAY DISCUSSION TO UNDERSTAND THIS LONG-STANDING CONFLICT.

YOU CAN LISTEN AT KPBS.ORG OR WHEREVER YOU GET YOUR PODCASTS.

>>> PREGNANCY CENTERS HAVE BECOME A NEW FOCUS ON THE DEBATE OVER ABORTION.

TRYING TO BAND THEM.

AND NOW TELLING US THAT A SAN DIEGO COUNTY SUPERVISOR IS PROPOSING LOCAL ACTION.

>> THESE ARE FAKE CENTERS.

>> DISTRICT 3 SUPERVISORS ARE ASKING THE BOARD TO CONSIDER A POLICY TO EXPLORE LAWSUITS THAT COULD SHUT DOWN 16 CRISIS REGNANT SEE CENTERS.

>> THEY ARE FAKE CENTERS THAT ARE PRETENDING TO OFFER HEALTHCARE ADVICE TO WOMEN.

LURING UNSUSPECTING WOMEN TO MISLEADING INFORMATION FOR WOMEN THAT ARE LOOKING FOR MEDICAL ADVICE AND MEDICAL HELP.

>> THESE TYPES OF CLINICS HAVE BEEN OPERATING FOR DECADES.

THINGS HAVE CHANGED IN RECENT YEARS.

>> THEY ARE DOING A LOT OF ADVERTISING.

WHEN WOMEN ARE LOOKING AND THEY GOOGLE PREGNANCY HEALTH, QUESTIONS, ABORTION, PRENATAL CARE, THESE CENTERS ARE COMING UP ON THEIR SEARCH ENGINE.

>> INITIATING LEGAL ACCENTS AGAINST PREGNANCY CENTERS.

THE CHIEF MEDICAL OFFICER WITH PLANNED PARENTHOOD OF THE SOUTHWEST.

>> THEY ARE DANGEROUS AND THEY ARE RUN BY ANTIABORTION VOLUNTEERS THAT ARE NOT TRAINED MEDICAL PROFESSIONALS AND THEY SPREAD MISINFORMATION ABOUT ABORTION IN SERVICE OF THEIR OWN POLITICAL AGENDA.

>> EXECUTIVE DIRECTOR AT THE CLINIC.

SHE SAID THAT IF THE BOARD REALLY WANTED TO AID WOMEN IN UNSUPPORTED PREGNANCIES THEY WOULD BE PROMOTING PREGNANCY CENTERS NOT TRYING TO SHUT THEM DOWN.

A TRAVESTY THAT THEY ARE DIRECTLY TARGETING CENTERS AND THE MISSION IS TO AID WOMEN AND NO COST BECAUSE THEY ARE PRO- ABORTION WE ARE NOT.

THE POLICY WOULD CREATE A PUBLIC EDUCATION CAMPAIGN ABOUT THE CENTERS AND PROVIDE MORE INFORMATION ABOUT REPRODUCTIVE HEALTH RESOURCES INCLUDING ABORTIONS TO RESIDENCE.

HER REQUEST WILL BE CONSIDERED AT TUESDAY'S REGULAR BOARD MEETING.

>>> YOUR GENERAL SETUP HERE HAS BEEN DRY AIR ACROSS SOCAL.

WE DO HAVE SOME ACTION TO CONTEND WITH AS WE HEAD OVER THESE NEXT FEW DAYS.

WE WILL START ON A COOLING TREND.

THE WIND WILL CONTINUE TO RAMP UP.

WE WILL TELL YOU HOW DUSTY THAT WHEN WILL GET INTO THE MIDDLE OF THE WEEK AND HOW COOL IT WILL GET WITHIN THE NEXT FEW DAYS.

>>> TOMORROW IS THE FINAL DAY TO VOTE IN THE SPECIAL ELECTION DISTRICT FOUR.

TAKING A LOOK AT WHAT FUNDRAISING NUMBERS SAY ABOUT THE RISK.

>> EARLY VOTING HAS BEEN UNDERWAY FOR WEEKS NOW.

TUESDAY IS THE DEADLINE TO CAST YOUR BALLOT.

THE PRIMARY ELECTION HAD A CLEAR WINNER.

MONICA MONTGOMERY.

THE DEMOCRAT WON 42% OF THE VOTE.

IN A RUNOFF WITH AMY RIKER THAT CAME IN SECOND WITH 29%.

THE TWO HAVE RAISED THE SAME AMOUNT OF MONEY THIS YEAR WHEN YOU LOOK AT THEIR OFFICIAL CAMPAIGNS.

THE BULK OF CAMPAIGN SPENDING COMES FROM OUTSIDE OF INTEREST GROUPS.

A COALITION OF LABOR UNIONS RAISED NEARLY $1 MILLION THIS YEAR.

NO OUTSIDE GROUP RAISED ANYWHERE NEAR THAT AMOUNT.

THE REGISTER OF THE ORDERS SAID THAT THEY WERE SENT TO MAIL BALLOTS.

YOU CAN STILL VOTE IN PERSON TUESDAY AT ANY OF 22 BOAT CENTERS OPEN FROM 7:00 A.M. TO 8:00 P.M. TO FIND THE CLOSEST TO YOU, YOU CAN GO ONLINE.

>> WE HAVE ALL THE INFORMATION YOU NEED ABOUT THE SPECIAL ELECTION ON OUR WEBSITE.

CLICK ON THE VOTER WEB TAB YOU CAN FIND ON OUR HOMEPAGE.

>>> A COUNTY COURT JUDGE CANNOT APPLY FOR THE OPEN PUBLIC DEFENDER POSITION.

MICHAEL WASHINGTON IS NOT QUALIFIED FOR THE POSITION BECAUSE OF A 1947 STATUTE THAT A PERSON HAS TO BE A PRACTICING ATTORNEY IN THE YEAR PRECEDING THE DATE OF HIS ELECTION TO BE ELIGIBLE FOR THE OFFICE.

WASHINGTON ARGUED THAT DENYING HIM THE RIGHT TO APPLY FOR THE JOB IS ABSURD AS HE WORKED AS A PUBLIC DEPUTY DEFENDER FOR NINE YEARS.

AND HAS HANDLED EXTENSIVE CRIMINAL TRIALS.

THE ORANGE COUNTY JUDGE SIDED WITH THE COUNTY.

HAVING PUT THE SEARCH ON HOLD.

AND NOW IT WILL RESUME THAT SEARCH.

>>> FORMER PRESIDENT DONALD TRUMP TOOK THE WITNESS STAND IN NEW YORK TODAY.

HIS TESTIMONY BECAME A SPARRING MATCH WITH THE JUDGE.

BRINGING US MORE FROM THE PROCEEDINGS.

>> EVEN BEFORE THE CIVIL FRAUD TRIAL ON MONDAY, THE TONE WAS SET.

>> I KNOW YOU WILL ENGAGE IN NAME CALLING, TAUNTS AND RACE BAITING.

>> MANY REPRESENTATIVES I WILL BE DEALING WITH AND THE RACIST ATTORNEY GENERAL.

>> WHEN MEDIA CAMERAS LEFT THE COURTROOM, IT DID NOT TAKE LONG FOR QUESTIONING TO GET HEATED.

PRESS TO DEFEND HIS ORGANIZATION'S FINANCIAL DEALINGS AND HOW IT EVALUATED THE WORTH OF HIS EXPENSIVE REAL ESTATE PORTFOLIO.

THE JUDGE DIRECTED HIM TO KEEP HIS ANSWERS CONCISE.

REPORTERS SAY THAT TRUMP CALLED THE ATTORNEY GENERAL NAMES SEVERAL TIMES AND EIGHT POLITICAL WITCHHUNT.

IF YOU CANNOT CONTROL HIM, I WILL.

ADVERSARIAL ANSWERS WERE MOUNTING AND THE JUDGE TRYING TO REMOVE THE PRESIDENT FROM THE WITNESS STAND.

THIS CASE IS PERSONAL FOR TRUMP AND IT QUESTIONS HIS REPUTATION AS A BILLIONAIRE.

HE SPOKE TO REPORTERS AFTER WRAPPING HIS TESTIMONY.

>> ON BEHALF OF THE COURT.

>> THE ONLY THING THAT MATTERS ARE THE FACTS AND THE NUMBERS.

NUMBERS DO NOT LIE.

KPBS NEWS.

>>> HAVE YOU EVER GOT IN A PARKING TICKET.

DATA ANALYZED THAT IT IS LIKELY THAT YOU HAVE.

TELLING US WHERE YOU'RE MOST LIKELY TO GET A TICKET.

>> IN THE THREE WEEKS THAT I HAVE LIVED HERE, I HAVE GOTTEN MAYBE SIX OR SEVEN.

>> IF YOU RUN UP THERE TO DO SOMETHING, YOU GET A TICKET RIGHT AWAY.

>> I'VE BEEN TICKETED SIX TIMES IN THE LAST MONTH.

>> THEY ARE A PART OF LIFE IN SAN DIEGO.

MOST SAN DIEGANS HAVE PARKING TICKET STORIES OF THEIR OWN.

THE CITY OF SAN DIEGO HAS HANDED OUT 5 MILLION PARKING CITATIONS.

WONDERING WHAT THE MOST COMMON DAY TO GET A PARKING TICKET IS, THURSDAY.

19% OF ALL CITATIONS IN THE LAST DECADE.

ON THE OTHER HAND, THE LEAST COMMON DAY IS SUNDAY.

ONLY 2% OF ALL CITATIONS.

THE MOST COMMON IS VIOLATING SUITE STRIPPING SIGNS.

WITH 1.1 MILLION CITATIONS AND $60 MILLION IN FINES.

MISSION BEACH RESIDENTS SAY THAT THE YEAR OF TICKETS IS THERE.

HE HAS TO WORK ON ONE TATTOO FOR HOURS AT A TIME AND HE DOES NOT HAVE EMPLOYEE PARKING.

>> IT IS VERY INCONVENIENT TO HAVE TO LEAVE WHERE I AM TO GO GET MY CAR.

>> BEACHSIDE AREAS ACROSS THE CITY ALSO ARE HIGH ON THE LIST FOR CITATIONS.

MISSION IN PACIFIC BEACH PARKING IS METERED ARE ONLY AVAILABLE FOR LIMITED TIMES.

IT ACTUALLY HELPS BUSINESSES.

THE EXECUTIVE DIRECTOR OF DISCOVER PACIFIC BEACH.

>> THE BUSINESSES WANT TO SEE PEOPLE TURNING OVER THE PARKING SPACES THAT ARE RIGHT IN THEIR BUSINESSES.

THEY ALLOW FOR MORE VISITORS IN THOSE BUSINESSES.

>> THE MOST COMMON CITATION WAS TO VIOLATE STREET SHAPING SWEEPING SIGNS.

DURING THE LAST 10 YEARS, $65,000 IN STREET SWEEPING TICKETS ON MISSION BOULEVARD.

THAT CAN INCREASE IN THE COMING YEARS.

LAST MAY THE CITY ANNOUNCED IT WILL INCREASE THE FREQUENCY OF STREET SWEEPING FROM THREE DAYS TO FOUR.

HE GOT A TICKET BUT SAYS THAT HE RARELY SEES STREET SWEEPERS.

>> I'M BOMBED, I HAVE TO PAY OFF STUDENT LOANS AND I HAVE OTHER BILLS TO PAY.

SEEING THESE TICKETS DOES NOT HELP OUT WITH THAT.

I DO NOT SEE ANY STREET SWEEPING GOING ON.

>> JUST BECAUSE THEY DO NOT SEE THE STREET SWEEPER, DOES NOT MEAN IT WILL NOT COME THROUGH.

A SPOKESPERSON FOR THE CITY.

>> WE NEED TO BE ABLE TO MAKE SURE THAT WE HAVE A PREDETERMINED TIME WHEN THE CARS WILL BE CLEARED SO WE CAN GO IN AND SWEEP THE STREETS.

>> SAYING THAT MONEY FOR PARKING CITATIONS GOES TO THE CITY GENERAL FUND WHICH PAYS FOR PUBLIC LIBRARIES, PARKS AND EVEN PARKING ENFORCEMENT.

IT ALSO HAS THE NUMBER OF PARKING TICKETS FOR OVER THE PAST DECADE, FIFTH AVENUE HAS BEEN A TOP PLACE TO RECEIVE A TICKET AT A METER.

THE CITY COLLECTED $1 MILLION FROM EXPIRED METER CITATIONS ON FIFTH AVENUE ALONE.

THIS MAY BE CHANGING.

THE CITY BLOCKED OFF PORTIONS OF FIFTH AVENUE TO CARS.

CREATING THE PROMENADE.

IF YOU ARE PARKING TICKETS AS WELL.

THE EXECUTIVE DIRECTOR OF THE ASSOCIATION.

>> BEFORE, A LOT OF PEOPLE DRIVING UP AND DOWN FIFTH AVENUE LOOKING FOR THAT MAGIC SPOT THEY CAN NEVER FIND.

REALLY WITH ALL OF THE PARKING THAT WE HAD UP AND DOWN FIFTH AVENUE, WE ONLY TOOK AWAY 30 SPACES.

WITH THE REMOVAL OF THOSE 30 SPACES ON FIFTH AVENUE, WE TRIED TO ADD SPACES ON FOURTH AVENUE, SIXTH AVENUE AND ON THE CROSS STREETS.

>> THE REST OF DOWNTOWN CAN HAVE THE SAME NUMBER IF NOT MORE PARKING VIOLATIONS.

SAN DIEGANS WILL HAVE THEIR DAYS RUINED BY A STRIP OF PAPER ON THEIR WINDSHIELDS.

>> FOR AN INTERACTIVE MAP FOR THE PARKING TICKETS CAVING OUT IN THE LAST DECADE, YOU CAN GO TO KPBS.ORG.

>>> IVAN RODRIGUEZ SHOWS WHAT ELSE THE CDC IS DOING TO PREVENT THE SPREAD OF ILLNESS THIS HOLIDAY SEASON.

>> FAMILIES GATHER AND TEMPERATURES DIP AND HEALTH CONCERNS RISE.

>> BEING INDOORS IN CLOSE PROXIMITY TO US IS WHAT KICKS OFF RESPIRATORY VIRUS SEASON.

>> THE CDC IS EXPANDING ITS SURVEILLANCE PROGRAM TO TEST FOR MORE THAN 30 PATHOGENS INCLUDING FLU AND RSV.

>> THE TRAVELER PROVIDES CRITICAL INFORMATION THAT CAN HELP US FIND THINGS BEFORE THEY SPREAD IN OUR COMMUNITIES AND HELPS PUBLIC HEALTH OFFICIALS DETERMINE WHAT PREVENTION MEASURES WILL BE NEEDED.

>> BEGAN IN 2021 TO TRACK VARIANCE CREATING NASAL SWABS AND ANALYZING WASTEWATER FROM CERTAIN FLIGHTS.

>> WE HOPE TO DO THE SAME AND HAVE THE SAME SUCCESS WITH EARLY DETECTION.

AND FILLING IN THE GAPS WITH OTHER RESPIRATORY VIRUSES.

>> FOR TRAVELERS HITTING THE ROAD THIS HOLIDAY SEASON, WITH THE CDC RECOMMENDING TAKING A FEW STEPS TO HELP KEEP YOU AND YOUR FAMILY HEALTHY.

>> BASIC THINGS LIKE HAND WATCHING AND CARRYING HAND SANITIZER IF YOU CANNOT WASH YOUR HANDS.

>> ACCORDING TO DATA FROM THE CDC, THE WAY THAT HOSPITALIZATIONS REMAIN STEADY.

I AM IVAN RODRIGUEZ REPORTING.

>> GIVING A BOOST TO SAN DIEGO EFFORTS IN THE REGION.

ERIC ANDERSON HAS MORE ON WHO WILL BENEFIT.

>> AIR QUALITY REGULATORS ARE GETTING A MILLION-DOLLAR BOOST FOR EMPOWERING LOCAL COMMUNITIES STRUGGLING WITH POLLUTION ISSUES.

HOPING THE MONEY WILL IMPROVE MONITORING IN AREAS WITH THE REGION'S DIRTIEST AIR.

>> THERE IS A LOT THAT IS IMPORTANT TO DO IN TERMS OF MAKING SURE THAT FOLKS UNDERSTAND THE ACCESS TO INFORMATION THAT MAKE SENSE TO THEM WHEN IT COMES TO AIR- QUALITY ISSUES.

>> THE MONEY WILL PAY FOR AIR- QUALITY MONITORING IN THE BORDER COMMUNITIES.

AIR POLLUTION CONTROL DISTRICT WILL WORK WITH EIGHT NEIGHBORHOOD GROUPS.

INCLUDING LOCAL AND STATE GOVERNMENT AGENCIES.

>> FINDING WAYS TO HELP COMMUNITIES UNDERSTAND AIR- QUALITY CHALLENGES.

IT IS VERY EXCITING.

>> ALSO FUNDING THE OUTREACH EFFORT WITH LOCAL NATIVE COMMUNITIES.

THEY AWARDED MONEY TO THE LHASA ME UP PROJECT WHICH HELPS FOR ENVIRONMENTAL JUSTICE OUTCOMES AND A NUMBER OF AREAS.

ERIC ANDERSON, KPBS NEWS.

>>> LET'S START YOU OFF WITH YOUR WEATHER HEADLINES, WHAT YOU NEED TO KNOW OVER THE NEXT FEW DAYS.

THE STORY WILL BE THE INCREASING WIND INTO THE EARLY WEEK.

WE ARE EXPERIENCING A WHOLE TREND AS WELL AS WE ARE INCREASING THE ONSHORE FLOW.

THEN WE HAVE A SHARP TURN IN EVENTS.

WE WILL START TO SEE THE OFFSHORE FLOW AS WE HAD THROUGH THE DAY ON WEDNESDAY.

THAT WILL INCREASE THE SANTA ANA WINDS.

FOR TONIGHT, THIS WILL CAUSE SOME TRAVEL PROBLEMS.

IN SAN DIEGO YOU'RE SITTING AT 70.

OCEANSIDE, 70 AS WELL.

NOW AS WE HEAD INTO THE DAY ON WEDNESDAY, THE WINDS WILL REALLY START TO RAMP UP AND WE WILL INCREASE THE OFFSHORE FLOW WHICH MEANS THE SANTA ANA WINDS ARE IN STORE AS WE HEAD INTO WEDNESDAY AND THURSDAY.

ACROSS SOCAL RIGHT AROUND THE DESERT AND MOUNTAINOUS REGIONS FROM SAN DIEGO.

AS WE TRAVEL A LITTLE FURTHER NORTH, DEALING WITH GUS BETWEEN 40 AND 60 MILES PER HOUR.

AN ELEVATED FIRE RISK.

WE WILL START ON A WARMING TREND AGAIN AS WE HEAD INTO THE LATER HALF OF THE WEEK.

IN THE MIDDLE, WE ARE COOLING.

MORE ON THE COAST.

THEN WE WILL SEE THE UPTICK IN TEMPERATURES THURSDAY AND FRIDAY AND SATURDAY.

NOW AS WE TRAVEL FURTHER INLAND, TEMPERATURES ARE A LITTLE COOLER TUESDAY AND WEDNESDAY.

LOW 70s.

THEN WE WILL SEE A RISE ON THURSDAY AND FRIDAY.

HIGHS BACK INTO THE 80s.

STAYING THAT WAY THROUGH SATURDAY.

THE COOLING TREND FOR THE MOUNTAINS.

A BIG ONE AS WE HEAD INTO THE DAY ON WEDNESDAY.

DROPPING 10 DEGREES TUESDAY AND WEDNESDAY.

THEN WE WILL RISE AGAIN AS WE HEAD INTO THE WEEKEND.

YOU WILL FEEL IT ACROSS THE DESERT.

NOT SEEING TOO MUCH OF A CHANGE FOR THE MIDDLE OF THE WEEK.

FOR THE DESERT WE WILL SEE THE DRAMATIC DROP ON WEDNESDAY.

IT WILL WARM AGAIN ON THE OFFSHORE FLOW.

FOR KPBS NEWS.

>>> TONIGHT ON THE NEWS HOUR, ISRAELI FORCES CRAWL IN AS THE SECRETARY OF STATE TRIES TO PREVENT ESCALATION UP NEXT AFTER EVENING EDITION ON KPBS.

>>> THE MEN'S BASKETBALL TEAM IS GEARING UP FOR ANOTHER BIG SEASON THIS YEAR.

THEY WILL HOLLISTER FULLERTON WITH A SEASON OPENER TONIGHT.

THEY WILL HONOR THE 2022 AND 2023 TEAM THAT MADE IT TO THE FINAL FOUR LAST SEASON WITH A BANNER RAISING AHEAD OF THE GAME.

IT STARTS AT 7:30 AND WILL BE TELEVISED ON FS ONE.

THEY WILL NOT BE PLAYING FOR THE CHAMPIONSHIP IN FRONT OF THEIR HOME CROWD AFTER THE HEARTBREAKING LOSS IN FRONT OF THE NWS L SEMI FINAL.

>> POSTED IN.

I THOUGHT IT WAS GOING ONE.

>> THE DECISIVE GOAL WAS SCORED EARLY IN THE SECOND HALF.

GIVING THEM A 1-0 VICTORY.

A NEW VICTORY FOR CROWD ATTENDANCE.

32,000 PEOPLE IN THE STANDS.

THE CHAMPIONSHIP ON SUNDAY AND SATURDAY WILL FOCUS THE GOTH MFC AND IT WILL BE THE FINAL MATCH FOR MEGAN RUBINO AND ALLIE GREGOR.

THE WORLD CUP CHAMPIONS HAVE ANNOUNCED THEIR RETIREMENTS.

>>> THE HUMAN BRAIN INITIATIVE HAS PUBLISHED 21 PAPERS IN THE JOURNAL OF SCIENCE REVEALING A MAP OF THE HUMAN BRAIN.

SAN DIEGO SCIENTISTS HAVE PLAYED A BIG ROLE IN THE PROJECT.

SAYING THAT THEY HAVE SHOWN HOW GENETICS IN THE BRAIN CAN AFFECT SOMEONE'S MENTAL HEALTH.

>> FUNDED BY THE NATIONAL INSTITUTE OF HEALTH HAS IDENTIFIED 3000 DIFFERENT BRAIN CELL TYPES.

SCIENTISTS HAVE COMPARED THIS INITIATIVE TO THE HUMAN GENOME PROJECT.

A MOLECULAR GENETICIST AND YOU SEE SAN DIEGO.

DEPENDING ON HOW THE GENES ARE ACTIVATED.

>> CHANGES IN SEQUENCE OF THE DNA CAN MAKE SOMEONE MORE LIKELY TO PSYCHIATRIC DISEASES SUCH AS DEPRESSION.

OR ADDICTION.

>> SAN DIEGO RESEARCHERS WORKING AS A TEAM ARE LOOKING AT HOW GENES WITHIN THE BRAIN CELLS ARE SWITCHED ON AND OFF.

WORK IS DIVIDED BETWEEN ANOTHER PLACE RIGHT ACROSS THE STREET.

LAST YEAR THEY RECEIVED $77 MILLION.

THE BIGGEST GRAND IN HISTORY TO WORK ON THE INITIATIVE.

A NEUROSCIENTIST SAID THAT CALLING THE NEW RESEARCH A MAP OF THE BRAIN IS ABSURD BECAUSE THE INITIATIVE HAS A LONG WAY TO GO.

THE RESEARCH DONE IN SAN DIEGO SHOWS HOW GENES CAN AFFECT BRAIN CELLS FOR GOOD OR FOR BAD.

SAYING A KEY PART OF THIS IS IDENTIFYING THE KINDS OF CELLS THAT CAN BE COMPROMISED BY GENETIC VARIANCE.

>> THE GENETIC VARIANCE THAT GIVE US THE ABILITY IS MORE IMPORTANT IN ONE CELL TYPE AND NOT THE OTHERS.

>> THE RESEARCHERS THAT I SPOKE TO WERE CAREFUL TO DESCRIBE THEIR FINDINGS IN MODEST TERMS.

THEY CANNOT YET SAY GENETIC EFFECTS ON CELLS CAUSE PSYCHIATRIC DISEASES.

THE BEGINNINGS REPRESENT THE BIG STEP FORWARD.

>> POINTING OUT THE TYPE OF CELLS IN THE TYPE OF GENES IN THE TYPE OF PATHWAYS THAT ARE LIKELY INVOLVED.

A CANDIDATE LIST.

THE NEXT STEP IS TO FURTHER NARROW IT DOWN ON THE LIST AND PINPOINT ONE OF THE CRITICAL GENES.

>> ALL OF THE RESEARCH DONE HAS RELIED ON SAMPLES OF THREE BRAINS FROM THREE MALE DONORS.

GIVEN THE COMPLEXITY OF THE HUMAN BRAIN, THEY WILL NEED A LOT MORE SAMPLES IN THE FUTURE.

>> WITH THE HUMAN BRAIN, EACH BRAIN IS DIFFERENT.

VARIABILITY IS VERY HIGH.

TO BE ABLE TO FIND CORE THINGS IN THE VARIABLE, YOU NEED A LOT OF BRAINS TO ANALYZE.

THAT IS WHY I SAY WE NEED TO GO BIG.

>> RESEARCHERS HAVE DONE MANY EXTENSIVE STUDIES OF THE MOUSE BRAIN AND SAYING THAT WE DO HAVE A GOOD MAP OF THAT.

THE MOUSE BRAIN IS MADE UP OF 80 MILLION NEURONS.

THE HUMAN BRAIN HAS 80 BILLION NEURONS.

TOM IS FUDGE, KPBS NEWS.

>>> HERE'S WHAT WERE LOOKING FOR TOMORROW.

CLIMATE CHANGE MEANS THAT AMERICANS WILL HAVE MORE DAYS OF HAZARDOUS HEAT.

THE PROBLEM IT POSES FOR MOST OF THE COUNTRY'S HOUSING.

>>> MID-DAY DISH AND IS DISCUSSING ARTIFICIAL INTELLIGENCE.

ONE YEAR SINCE CHAD GPT WAS RELEASE.

YOU CAN FIND TONIGHT STORIES ON OUR WEBSITE, KPBS.ORG.

THANK YOU FOR JOINING US.

HAVE A GREAT EVENING.

>>> MAJOR FUNDING FOR KPBS EVENING EDITION HAS MADE POSSIBLE BY BILL HOWE FAMILY OF COMPANIES.

PROVIDING SAN DIEGO WITH PLUMBING, HEATING AND AIR, RESTORATION, FLOOD AND REMODELING SERVICES FOR OVER 40 YEARS.

CALL 1-800-BILL-HOWE OR VISIT BILLHOWE.COM AND BY THE CONRAD CREVICE FOUNDATION.

AND BY THE FOLLOWING.

AND BY VIEWERS LIKE YOU, THANK YOU.