>>> COMING UP NEXT ON ARIZONA HORIZON: CAN PRESIDENT TRUMP SERVE A 3RD- TERM, AS SOME OF HIS SUPPORTERS MAINTAIN?

ALSO TONIGHT: AN UPDATE ON AN IMMUNO-THERAPY TREATMENT FOR GLIO-BLASTOMA.

AND, THE MUSICAL INSTRUMENT MUSEUM IS ABOUT TO OPEN A NEW EXHIBIT THAT CELEBRATES THE WORLD'S 1ST-WIND INSTRUMENT, THE FLUTE.THOSE STORIES AND MORE, NEXT, ON ARIZONA HORIZON.

>>> ARIZONA HORIZON MADE POSSIBLE BY CONTRIBUTIONS BY THE FRIENDS OF ARIZONA PBS.

MEMBERS OF YOUR PUBLIC TELEVISION STATION.

>>> GOOD EVENING AND WELCOME TO ARIZONA HORIZON.

I'M TED SIMONS.

CONSTITUTIONAL SCHOLARS SAY THAT THERE'S NO LEGAL PATH THAT ALLOWS A PRESIDENT TO SERVE MORE THAN 2- TERMS.

BUT THAT'S NOT STOPPING PRESIDENT TRUMP'S SUPPORTERS FROM SAYING THAT A "3RD" TRUMP TERM IS VERY MUCH A POSSIBILITY AND THAT PLANS ARE IN THE WORKS TO MAKE IT HAPPEN.

JOINING US NOW IS FORMER ASSISTANT U.S.-ATTORNEY ROY HERRERA, FOUNDING PARTNER OF HERRERA ARELLANO, LLP.

GOOD TO SEE YOU.

CAN HE DO IT?

>> THE SHORT ANSWER IS NO.

THAT THE POSITIONS LEGAL SCHOLARS WILL TAKE.

THE U.S.

CONSTITUTION AND DESIGNED PROHIBIT EVERYONE FROM SEVERING TWO TERMS.

IT'S REALLY IMPORT AND IT BECAUSE NO PERSON SHALL BE ELECTED MORE THAN TWICE.

IT'S IMPORT TAN TO THINK ABOUT WHY WE HAVE A 22nd AMENDMENT.

THAT HAD TOE DO WITH FRANKLIN ROOSEVELT THAT SEVERED FOUR TERMS AS PRESIDENT.

THERE WAS A LIMIT TO BANNING THAT PRACTICE.

THAT'S WHY WE HAVE THE 22nd AMENDMENT.

>> THE IDEA YOU COULD SERVE.

PEOPLE SAY HE ONLY SEVERED ONE TERM AND CAN RUN AGAIN.

HOW DOES THAT WORKOUT.

>> DONALD TRUMP DID THAT.

>> HE DID DO THAT.

MOST PEOPLE WOULD BELIEVE THAT'S IN LINE WITH WHAT THE 22nd AMENDMENT CONTEMPLATES.

YOU CAN'T BE ELECTED MORE THAN TWICE.

HE WAS ELECTED TWICE.

THERE ARE PROPONENTS OF THE IDEA OF A THIRD SERVE.

IT DOESN'T BAR HIM FROM SEVERING.

THERE IS A MEANING IN THE WORDY ELECTED IN THE THANK YOUENED AMENDMENT DIFFERENT FROM THE WORD SERVE.

THEY WOULD ARGUE.

TWENTY-SECOND AMENDMENT SAY YOU MIGHT NOT GET ELECTED A THIRD TIME BUT DOESN'T MEAN YO CAN'T SERVE.

THAT'S THE LOOPHOLE THEY ARGUE.

>> THERE ARE A FEW LOOPHOLES BAUDS OF THE VICE PRESIDENT.

SAY J.D.

VANCE WINS IN 2028.

COULD HE APPOINT DONALD TRUMP AS THEY UNVENTED DOGE.

HE WILL SERVE IN THAT CAPACITY AS PRESIDENT OF THE UNITED STATES.

THERE IS A LATITUDE IN WHICH THEY COULD DESIGNATE SOMEONE.

I THINK THE PRECEDENT IS COMMANDER AND CHIEF ON ISSUES OF IMPORTANCE.

IF YOU DECIDE TO DO SOMETHING LIKE THAT, THE BIGGEST STOP IS THE AMERICAN PEOPLE DECIDING WELL, THAT'S NOT WHAT WE VOTED FOR AND DON'T LIKE THE IDEA.

HE COULD GIVE POWERS OVER TO PRIVATE CITIZENS LIKE TRUMP.

>> THAT'S WHAT I'D DO.

APPOINT HIM AS AMBASSADOR OR KING OF THE UNIVERSITY.

WHATEVER THEY WANT TO CALL IT AS LONG AS HE COULD HAVE THOSE POWERS.

>> THERE ARE QUITE A FEW SCENARIOS.

THAT IS ONE OF THEM.

PRESIDENT VANCE GETS ELECTED AND GIVING TRUMP A CERTAIN AMOUNT OF POWER.

ANOTHER SCENARIO IS WHAT HAPPENS IN A WORLD WHEN THEY ARE ELECTED.

THE PRESIDENT A.M.

TERM IS ABOUT TO START.

THE 20th AMENDMENT OF THE CONSTITUTION SAYS CONGRESS DECIDES.

THE HOUSE SPEAKER COULD BECOME PRESIDENT.

>> IT'S GOOD TO HAVE SOMEONE THAT DOESN'T SERVE IN CONGRESS.

>> THAT'S THE ELECTOR COLLEGE TIES.

THAT GOES TO THE HOUSE OF REPRESENTATIVES AND THEY DECIDE WHAT COULD BE A PRIVATE CITIZEN.

THE PRESIDENT AND VICE PRESIDENT.

>> PRIVATE CITIZEN WHO HAS BEEN ELECTED PRESIDENT BUT NOT ELECTED HERE.

>> EXACTLY.

>> THERE ARE EXTREME EXAMPLES THAT OPEN UP THE POSSIBILITY OF SOMEONE NOT THE ELECTED PRESIDENT BECOMING PRESIDENT.

WE HAVE THE 22nd AMENDMENT PROBLEM WHEN IT COMES TO TRUMP, OBAMA, OR CLINTON.

IF YOU INTERPRET IT LIKE MOST LEGAL SCHOLARS WOULD, UNDER ALL SCENARIOS HE WOULDN'T BE ALLOWED TO SERVE.

>> TRY THIS J.D.

VANCE RUNS FOR PRESIDENT AND DONALD TRUMP IS HIS RUNNING MATE.

EVERYONE KNOWS IF YOU ELECT J.D.

VANCE YOU ELECT DONALD TRUMP AND SWITCH, YOU KNOW, SWITCH OFFICES.

SANCTION COULD PROBABLY STILL BE CALLED PRESIDENT VANCE.

>> THAT'S THE SCENARIO THEY ARE FOCUSED ON.

PRESIDENT VANCE IS ELECTED AND RESIGNS AND VICE PRESIDENT BECOMES ELECTED AGAIN.

STILL WE HAVE THE 22nd AMENDMENT PROBLEM.

MOST WOULD SAY, THERE IS NO DIFFERENCE WHEN THE DRAFTERS PUT THAT TOGETHER.

THEY DIDN'T SEE A DIFFERENCE BETWEEN ELECT AND SERVE.

THE POINT IS TO PREVENT ANYONE THAT SEVERED TWO TERMS TO SERVE ANY MORE THAN THAT.

IF YOU LOOK AT THE HOOP HOPE IT DEFENDS THE WHOLE PURPOSE AND WHY IT WAS ENACTED AFTER FDR.

>> THERE IS ALSO SOME TALK, THE HINTING AND SUGGESTING TO KEEP IT IN THE NEWS TO LOOSEN UP THE SUPREME COURT SO THIS IS NOT A SHOCK TO THE SUPREME COURT BUT SOMETHING THEY MIGHT WANT TO OR HAVE TO CONSIDER, DOES THAT MAKE SENSE?

>> WELL, IT SOUNDS LIKE, YOU KNOW, SOME OF THE THINGS THIS ADMINISTRATION HAS TRIED TO DO IN THE PAST ON NOVEL LEGAL THEORIES.

TO PREVIEW THEM BEFORE THE U.S.

SUPREME COURT.

THIS IS AN ISSUE NO ONE HAS DEALT WITH BECAUSE NO ONE TRIED SINCE WE HAD THE 22nd AMENDMENT TO SERVE A THIRD TIME.

OTHER THAN FDR, BEFORE FDR IT HAD BEEN TRADITION NO PRESIDENT SEVERED MORE THAN TWO TERMS USING THE EXAMPLE OF GEORGE WASHINGTON WHO SEVERED TWO TERMS.

IT HADN'T BEEN LAW YET.

FDR, THAT HAPPENED, THERE WAS REASONS FOR THAT A WAR AND GREAT DEPRESSION.

AFTER THAT WAS THE DECISION TO BAR THAT PRACTICE.

>> LAST QUESTION, COULD DONALD TRUMP, AS PRESIDENT, DECLARE A NATIONAL EMERGENCY COME 2027-28 AND BASICALLY SAYS, THERE IS A NATIONAL EMERGE AS I SEE FOR WHATEVER REASON HE DECIDES, ELECTIONS, ESPECIALLY FOR PRESIDENT AND COMMANDER AND CHIEF.

THESE ARE CALLED OFF OR SUSPENDED FOR NOW.

COULD HE DO THAT AND STAY IN OFFICE?

>> NO, THERE IS NO PROCESS FOR THAT TO OCCUR AND SET ASIDE THE OUTCOME OF THE ELECTION AND REMAIN AS PRESIDENT.

THERE ARE EXTREME EXAMPLES.

THERE IS A SCENARIO WITH AN ELECTORAL COLLEGE.

THE LAW PROVIDES FOR PATH WAYS TO DEAL WITH THAT SCENARIO.

THERE IS NO SITUATION TO DECLARE A NATIONAL EMERGENCY AND STAY ON AS A RESULT OF THE NATIONAL EMERGENCY AS THE THIRD TERM PRESIDENT.

>> PUT-ON YOUR POLITICAL HAT, IS THIS A WAY TO MAKE HIM, SO HE DOESN'T LOOK LIKE A LAME DUCK.

>> I THINK THAT'S A LOT OF IT HERE.

EVERY PRESIDENT, IN THE SECOND TWO YEARS WANTS TO RUN FOR REELECTION.

THIS COULD BE A METHOD OF HIM TRYING TO HOLD ONTO THAT POWER AND I THINK ABOUT, YOU KNOW, TO THE BEST I COULD UNDERSTAND, AT THE END OF THE DAY.

THIS IDEA THAT ON THE HE CAN SERVE IN THE WAY HE DOES.

AS PRESIDENT AND THERE FOR THE COUNTRY NEEDS HIM TO CONTINUE.

THAT'S WHAT I THINK IS HAPPENING HERE.

THERE ARE ALL SORTS OF ROADBLOCKS HERE.

>> ALWAYS A PLEASURE.

GOOD CONVERSATION.

>> THANK YOU VERY MUCH.

>>> GLIOBLASTOMA IS AN AGGRESSIVE BRAIN CANCER, WITH FEW EFFECTIVE TREATMENT-OPTIONS AVAILABLE.

BUT RESEARCHERS AT BANNER MD ANDERSON CANCER ARE MOVING TO PHASE-2 OF A CLINICAL TRIAL THAT USES A PATIENT'S OWN TUMOR CELLS TO CREATE A PERSONALIZED IMMUNO- THERAPY.

TO LEARN MORE, WE WELCOME DR.

RAMYA TADIPATRI, A NEURO- ONCOLOGIST AND PRINCIPAL INVESTIGATOR WITH BANNER MD ANDERSON CANCER CENTER AND WE ALSO WELCOME DR.

JOSEPH GEORGES, NEUROSURGEON AND LONGTIME RESEARCHER IN IMMUMNOTHERAPY DEVELOPMENT, HE'S ALSO WITH BANNER MD ANDERSON.

GOOD TO HAVE YOU BOTH HERE.

WE'LL TART WITH YOU DOCTOR.

IT'S ALMOST LIKE, IT SEEMS LIKE THERE IS NOT A LOT IN THE WAY OF DEVELOPMENT.

WHY IS IT SO HARD TO TREAT?

>> YEAH, IT'S A GREAT QUESTION.

WITH ANY TYPE OF CANCER, THE TUMOR CAN BE PRETTY SMART.

IT MUTATIONS AROUND THE TREATMENTS THAT WE GIVE AND GLIOBLASTOMA CAN BE RESISTANT.

WE HAVE A BLOOD BRAIN BARRIER.

>> IS EARLY DETECTION A BIG PART OF TREATING HERE OR IS THAT NOT AS IMPORTANT?

>> ONE THING THAT'S HELPFUL WITH EARLY DETECTION IS WE, IDEALLY WANT TO TRY TO CATCH THE TUMOR BEFORE IT GROWS TO CAUSE NEURO LOGICAL SYMPTOMS.

WITH A LOT OF TREATMENTS, WE ARE UNABLE TO MEANINGFULLY SHRINK THE TUMOR.

ONCE THE PARTIAL DEVELOPS THESE SYMPTOMS IT'S DIFFICULT TO REVERSE.

>> AGAIN, IT SOUNDS LIKE THERE IS A PHRASE TWO OF A TRIAL.

HOW IS IT DIFFERENT?

>> PHRASE ONE LOOKS AT SAFETY AND PHRASE TWO IS EFFICACY.

IF WE SEE PROMISE IN ONE PHRASE TWO IS TO SEE IF IT'S WORKING.

>> TALK ABOUT THIS, SOUNDS LUKE IMMUNE KNOW THERAPY AND FINDING OUT HOW TO TREAT IT.

>> OUR IMMUNE SYSTEM HAS CELLS THAT CAN DETECT CANCER CELLS.

IT'S GOOD AT TRICKING THE IMMUNE SYSTEM AND HIDING FROM IT.

YOUR OWN BODY CAN'T FIGHT IT.

I GOT INVOLVED WITH THIS PARTICULAR LINE OF WORK WORKING WITH DR.DECKER.

WE DEVELOPED THE PHRASE ONE TRIAL.

JUST VERY PROMISING RESULT.

IT HAS MULTIPLE DOSAGES AND STARTED SEEING PATIENTS SURVIVE LONGER THAN EXPECTED.

>> WAS THAT A BIT OF A SURPRISE?

WHAT WERE YOU EXPECTING?

>> HAVING DONE A LOT OF RESEARCH, IT WAS SURPRISING.

WE DO WORK AND THINGS DON'T TURNOUT AS YOU HOPED THEY WOULD.

IN THIS CASE, WE STARTED TO SEE PATIENTS LIVE LONGER THAN EXPECTED.

I STARTED SEEING MRIs WHERE THE TUMOR LOOKED LIKE IT WAS MELTING AWAY.

ALMOST 24 MONTHS AFTERWARDS.

>> FOR YEARS, WE TALKED ABOUT IMMUNE KNOW THERAPY.

IS THIS SIMILAR TO IMMUNOTHERAPY.

>> IT'S A BROAD TERM.

IT'S USING YOUR IMMUNE SYSTEM TO FIGHT THE CANCER.

THERE ARE MANY WAYS TO DO THAT.

ONE OTHER TYPE IS CAR T CELL THERAPY.

>> YES, TALK ABOUT THAT.

>> THE ONE MAJOR DIFFERENCE IS THAT THERE IS A SPECIFIC TARGET WE TRAINED.

IT WORKED WELL AND WE HAD THAT ONE TARGET OR MOLECULE ON THE CELL.

THE CHALLENGE WE GLIOBLASTOMA IS IT'S A HERO GENIUS TUMOR.

>> INTERESTING.

>> WITH THIS APPROACH U WE DON'T HAVE TO FIND THE ONE TARGET.

THE IMMUNE IS TRAINED TO RESPOND.

>> WHEN IT TARGETS THIS IS IT MESSING OTHER STUFF UP AT THE SAME TIME?

HOW DOES THAT HAPPEN?

>> IT SMART ENOUGH NOT TO ATTACK NORMAL CELLS.

IT WILL TACKLE ANTIGENS.

THIS IS MADE FROM THE PATIENTS TUMOR AND ENCOMPASSES THE FULL THING.

>> SO, HOW LONG WILL THIS TAKE?

>> ROUGHLY TWO TO THREE YEARS.

>> WHAT ABOUT PHRASE ONE?

ONE TO TWO YEARS.

>> SEEMS LIKE YOU ARE ON THE RIGHT TRACK?

>> IT APPEARS TO BE.

WE ENROLLED 23 PATIENTS SO FAR.

WE LOOK FORWARD TO SEE WHAT THE RESULTS WILL BE?

>> I HAVE TO ASK YOU QUICKLY, ARE YOU ENCOURAGED OR OPTIMISTIC ABOUT THIS.

>> THE AVERAGE SURVIVAL WITHSTANDARD TREATMENTS IN THE SPAN OF 14 MONTHS.

PERSONALIZED APPROACHES AND SECOND LINE OFF LABEL THERAPIES PUSHING THAT CLOSER TO TWO YEARS.

THEY CAN SPEAK TO SEE MUCH FOR BETTER SURVIVAL SO FAR.

>> WE'LL HAVE TO ASK YOU BACK FOR THAT BECAUSE WE ARE RUNNING OUT OF TIME.

THIS IS VERY ENCOURAGING.

THANK YOU BOTH.

>> THANK YOU SO MUCH.

THE MIM IN PHOENIX IS LAUNCHING THE MAGICAL FLUTE, A SPECIAL EXHIBITION FEATURING MORE THAN 100 RARE INSTRUMENTS THAT TRACE THE FLUTE'S CULTURAL AND ARTISTIC SIGNIFICANCE ACROSS THOUSANDS OF YEARS.

FROM 8,000 YEAR-OLD CHINESE BONE FLUTES TO INSTRUMENTS USED IN BLOCKBUSTER FILMS LIKE JAWS AND TITANIC.

THIS IS CALLED THE MAGICAL FLUTE BEAUTY ENCHANTMENT AND POWER.

THIS WAS THE FIRST WIND INSTRUMENT.

>> THIS IS THE WORLD'S OLDEST.

WE HAVE EXAMPLES IT SPEAKS TO THE HUMAN EXPERIENCE OF MUSIC.

FROM WIND ACROSS THE CAVE THEY UNDERSTOOD THE PRINCIPAL OF MAKING A FLUTE.

I HAVE BEEN MAKING THEM FOR THOUSANDS OF YEARS.

>> EVERY CULTURE HAS A FLUTE OR WHISTLE WITH THAT SOUND.

TO CELEBRATE THE WORLD OLDEST INSTRUMENT.

WE HAVE THE FLEET DATING BACK TO 8,000 YEARS AGO.

HOW DO YOU PRONOUNCE THAT?

>> IT'S CRAFTED FROM WING BONE.

IT'S A REALLY FASCINATING THING.

IT'S SUCH A RARE INSTRUMENT.

>> 8,000 YEARS OLD?

>> YES, CORRECT THEY WITH PRODUCE A SERIES OF TONES.

>> REALLY, LET'S GO TO THE NEXT ONE.

IT WILL HAVE A MASK.

THIS IS A FLUTE?

WHAT ARE WE LOOKING AT HERE.

>> WE LOOK AT THE CEREMONIAL OUTFIT.

IT'S FROM THE CONGO.

IT'S WONDERFUL.

WITHIN THE EXHIBIT.

WE SHOW ALL SORTS OF OBJECTS THE HEAD DRESS IS 3.5 FEET TALL THE OUTFIT INVOKES THE SPIRIT AND THE WHISTLE MADE IN THE IMAGE OF THE OUTFIT TO INVOKE THE ANCESTOR AND PROTECT THEM ON THE HUNT.

>> WOW, ISN'T THAT SOMETHING.

>> WE HAVE AN EMPIRER'S FLUTE.

EDDY YOU WANT TO TALK ABOUT THIS ONE.

>> WE ARE TALKING ONE OF TWO FOR THE JAPANESE EMPIRER.

IT'S ORIGINALLY DECORATED WITH MULTIPLE LAYERS SHOWING AN ELABORATED MOTIF.

SHOWCASING A REMARKABLE BEAUTY.

>> VERY SPECIAL BUT DOES IT SOUND GOOD.

>> THIS LOOKS LIKE A FLUTE.

IT WAS MADE IN 1999.

IT'S MADE OF CARBON FIBER.

IT HAS MAGNETS INSTEAD OFFSPRINGS.

IT HAS GASKETS LIKE YOUR CAR.

IT'S REALLY A FUN INSTRUMENT TO SEE WHAT YOU CAN DO WITH THE FLUTE AND HOW YOU CAN CHANGE IT, MODERNIZE IT.

AND UPDATE IT.

>> THE FUNNY THING IS.

THE FLUTE CAME IN.

HER COMMENT IT SOUNDED LIKE AN OLDER WOODEN FLUTE RATHER THAN THE MODERN SILVER AND GOLD OUTFIT.

>> DO YOU WANT TO TALK ABOUT THE JAMES FLUTE.

SIR JAMES.

>> THAT'S BIG STUFF IN THE WORLD OF FLUTES.

>> THE FIRST THING I THOUGHT OF IS WE GOT TO GET A FLUTE.

THIS WAS THE MAN WITH THE GOLDEN FLUTE.

HE IS THE MOST ICONIC FLUTE PLAYER DURING MY LIFETIME AND MANY OF THE PEOPLE WHO LOVE FLUTE MUSIC TODAY SIR JAMES IS THE FIRST NAME THEY THINK OF.

>> HISTORICALLY WE SPOKE ABOUT HOW IMPORTANT IT WAS.

DOES ITS STILL SPAN CULTURES?

>> YES, WITH THIS SHOW, IT'S ABOUT CELEBRATING THE MAGICAL QUANTITIES AND POWER OF THE FLUTE.

WE HAVE ANCIENT BONE FLUTE.

ALSO, WE HAVE OTHER COSTUMES BY FAMOUS PRODUCTION.

DIFFERENT KINDS OF ELEMENTS ADD TO THE SHOW.

ONE BY ONE THEY SPEAK TO THE MAGICAL POWER OF FLUTES.

>> IT OPENS ON FRIDAY, WHERE CAN WE GO?

>> MIM.ORG.

>> ALL RIGHT, YOU HAVE A FLUTE OWNED BY NAPOLEON.

>> IT WAS A CRYSTAL FLUTE THAT WAS FACETED WITH 500 FACETS.

>> THAT'S YOU GOT FOR NOW.

I'M TED SIMONS.

YOU HAVE A GREAT