FRONTLINE presents Organ Farm
a collage of things
A History of Xeno Experiments

Xenotransplantation is not a recent phenomenon -- doctors have made sporadic attempts at cross-species transplants as early as the 17th century with little success. While primate donors were used in early whole organ experiments, pig insulin was first used to treat diabetics in the 1930s. Pig heart valves have been used in humans for several decades; however they are chemically treated first to kill any pig cells. Below is a history of some of the significant xeno experiments. For a detailed chart of all xeno experiments using cells or organs from non-human primates see the Council of Europe's July 2000 report on xenotransplantation.


home
four patients
risks
animal welfare
the business
the regulators

1963-64

  • Dr. Keith Reemtsma, a surgeon at Tulane University in New Orleans, transplants thirteen chimpanzee kidneys into humans. Twelve of the patients survive between nine and sixty days. One patient, however, survives for nine months on primitive immunosuppression drugs with no signs of rejection.
1964

  • While at the University of Colorado, Dr. Thomas Starzl transplants six baboon kidneys into humans. Survival rates range between nineteen and 98 days, with most patients dying of infections.
  • Dr. James Hardy of the University of Mississippi transplants a chimpanzee heart into a 68-year old semi-comatose man. The chimpanzee heart is too small to support the patient's circulatory system and only functions for two hours.
1977

  • Dr. Christian Barnard, the South African surgeon who had performed the first human heart allotransplant in 1967, attempts to use chimpanzee and baboon hearts as bridge organs in patients who had undergone unsuccessful open heart surgery. The recipient of the baboon heart dies after six hours, while the recipient of the chimpanzee heart survives for four days before it is rejected.
photo of baby fae 1984

  • Dr. Leonard Bailey leads a group of surgeons who transplant a baboon heart into a newborn infant, known as "Baby Fae," who was born with a poorly developed left side of her heart. She is treated with cyclosporine, an immunosuppressive drug that greatly increased survival rates in allotransplants, and survives for twenty days before the heart is rejected. Some have speculated that blood type incompatibility between Baby Fae and the donor baboon may have played a role in the rejection process.
1992

  • Dr. Thomas Starzl, now at the University of Pittsburgh, transplants a baboon kidney into a patient with AIDS and hepatitis B, because it is believed baboons are resistant to hepatitis B. The patient survives for 70 days, with no evidence of rejection. He dies of an infection his body could not fight off due to heavy immunosuppression. In the fall of 1999 it is discovered that archived blood and tissue samples of the patient contained baboon cytomegalovirus. It remains undetermined whether the virus had infected human cells or whether baboon cells had migrated from the liver into other tissues.
  • A Polish surgeon transplants a pig heart into a human patient, who survives for less than 24 hours. The cause of death is attributed to the small size of the heart, which could not support the body's circulatory system.
  • On Christmas Eve, scientists at Imutran deliver the first transgenic pig, which they name Astrid. The group of scientists, led by Dr. David White, had inserted a small amount of human DNA into a fertilized pig egg, in an attempt to create pig organs that would not be rejected by humans.
1993

  • Dr. Thomas Starzl again attempts transplanting a baboon liver into a patient suffering from hepatitis B. This patient never regains consciousness after the operation, and dies of infection under heavy immunosuppression. Starzl, who had received permission for several more xenotransplant operations, halts his program to perform further research regarding transplant rejection.
1995

  • Scientists at Diacrin, Inc. receive FDA permission to begin clinical trials using fetal pig neurons to treat patients suffering from Parkinson's disease. These Phase 1 trials when concluded show efficacy and no safety problems, leading to Phase 2 trials in the late 1990s.
  • In May, scientists from Nextran announce that they have developed transgenic pig hearts that survive as long as 30 hours inside baboons, as compared to the 60 to 90 minute survival time for regular pig hearts. In July, the FDA approves Nextran's proposal to use transgenic pig livers as bridge organs on up to ten patients.
  • AIDS patient Jeff Getty receives a transplant of baboon bone marrow cells at San Francisco General Hospital, performed by Dr. Suzanne Ilstaad. Because baboon stem cells are resistant to AIDS, the hope was that they would help Getty's bone marrow produce AIDS-fighting immune cells. The baboon cells do not take; they remain in Getty's system for only two weeks after the transplant. He is still alive and blood tests so far have not revealed any baboon viruses in his system.
1997

  • Professor Robin Weiss discovers that viruses embedded in every pig cell -- known as porcine endogenous retroviruses (PERV) -- can infect human cells in culture. In the journal Nature he reports that each pig cell carries approximately 50 copies of the PERV virus, and that up to three of them are capable of infecting human cells. As a result, in October the FDA halts all clinical trials until researchers can prove they have developed procedures to detect low levels of PERV virus infection. The moratorium is lifted in January 1998.
1998

1999

  • The FDA effectively bans use of nonhuman primates in xenotransplants, citing the risk of cross-species infection.
  • A study of 160 people who had received various pig tissues and/or cells reveals that none had been infected with the PERV virus. The study was conducted by researchers at Imutran, in collaboration with the CDC and reported in the journal Science.
2000

  • Scientists at PPL Therapeutics in Scotland announce in the journal Nature that they have cloned five piglets for the first time. A team of Japanese scientists announces in the journal Science that they have also cloned a piglet using a different method.
  • Scientists at Infigin announce in the journal Nature Biotechnology that they have produced two litters of transgenic, cloned pigs.
  • In the journal Nature, Dr. Daniel Salomon of the Scripps Research Institute announces the results of a study which found transmission of the PERV virus during a transplant of pig pancreatic cells into heavily immunosuppressed diabetic mice. This finding is the first evidence of cross-species transmission of a retrovirus during a transplant. Salomon found that the mice developed PERV infections that lasted for as long as two months before going dormant.
  • The British animal rights organization Uncaged Campaigns receives leaked documents of an Imutran study of the survivability of pig organs in primates over a five-year period. The study showed the average survival time was thirteen days, with a quarter of the primates dying within two days.
  • The International Society for Heart and Lung Transplantation issues a report which advises that clinical xenotransplantation trials should not be undertaken until authorities have determined a minimal virus risk, and until 60% of pig organs survive in non-human primates for a minimum of three months. However, they conclude "Xenotransplantation has the potential to solve the problem of donor organ supply, and therefore research in this field should be actively encouraged and supported."
2001

  • The FDA proposes a rule which would allow more public access to all new or ongoing trials regarding xenotransplantation or gene therapy to ensure public awareness of their unique potential for public health risks.
  • The United Kingdom Xenotransplantation Regulatory Authority (UKXIRA) publishes its third annual report, which states "Although alternative therapies are in development, xenotransplantation may still offer the prospect of a viable treatment within a worthwhile time frame. However, on the basis of current evidence, whole-organ xenotransplantation, as a solution to the ongoing shortage of organs for transplant, appears to be some way off." They conclude that they do not support a moratorium on xenotransplantation, and that until the infection risk is understood, they will assess particular procedures on a case-by-case basis.
March 2001

  • Preliminary analysis of Phase 2 controlled trials treating Parkinson's disease patients with injected pig neuro cells indicate a setback. Although there were improvements, the study found no difference in the improvements between the patients who had been treated with the pig cells and those who had a placebo treatment.


home · four patients · the risks · animal welfare · the business · the regulators
discussion · faqs · video · chronology · interviews
synopsis · tapes & transcripts · press · credits · carlton's organ farm
FRONTLINE · pbs online · wgbh

web site copyright 1995-2014 WGBH educational foundation

SUPPORT PROVIDED BY

RECENT STORIES

FRONTLINE on

ShopPBS
FRONTLINE Organ Farm